BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM

共同促进大脑健康:基于小组的直播数字节目

基本信息

  • 批准号:
    10324919
  • 负责人:
  • 金额:
    $ 150.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-30 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

Together Senior Health, Inc. (TOGETHER) is a woman-owned small business that is dedicated to helping older adults with cognitive decline or Alzheimer’s disease and related dementias (ADRD) maintain quality of life and independence by offering innovative, evidence-based, online, livestream, group programs. Our first product on the TOGETHER audio/video platform is Moving TogetherTM—which combines movements to support daily function with mindful body awareness exercises and social engagement and is designed for people with mild ADRD and their caregivers who participate together from home. The primary goal of this Phase II Small Business Innovation Research (SBIR) grant is to expand our product line by developing and testing a comprehensive BRAIN HEALTH TOGETHER program for people living with mild cognitive impairment (MCI). This goal represents a critically important next step for our company from both public health and business perspectives. Older adults with MCI represent a large market with important unmet needs: approximately 20% of older adults (>2.7 million Americans) are currently living with MCI, which places them at increased risk of developing ADRD. There are no medications that can prevent development of ADRD in people with MCI; however, there is growing evidence that behavioral interventions targeting modifiable dementia risk factors—such as physical inactivity, social isolation, and depression—may help improve cognitive function and could potentially delay dementia onset. Our preliminary results suggest that our product, Moving Together is associated with significant improvements in cognitive function, physical function, social isolation, and self-regulation as well as increased default mode network connectivity on pre/post resting state functional magnetic resonance imaging (rs-fMRI) scans in people with MCI. We believe that these benefits would be even greater if Moving Together were combined with a comprehensive brain health coaching program. Therefore, our Specific Aims are to: 1) Work with our Scientific Advisory Board and use humancentered design to develop evidence-based content for Brain Health Together, a 12-week, group-based, livestreaming, digital program that will combine Moving Together with brain health coaching to address modifiable dementia risk factors in people with MCI; 2) Perform a randomized, controlled trial to determine whether the Brain Health Together program improves cognitive function in people with MCI over 12 weeks compared to a Successful Aging comparison group; and 3) Determine whether weekly maintenance classes help to sustain the effects of the Brain Health Together program over 12 weeks after the intervention. If we can demonstrate that BRAIN HEALTH TOGETHER has immediate and sustained cognitive benefits in people with MCI, it will position TOGETHER as a national leader in evidence-based programs to improve quality of life and prevent decline in older adults with cognitive impairment.
Together Senior Health,Inc.(一起)是一个妇女拥有的小企业,致力于帮助 认知能力下降或阿尔茨海默病及相关痴呆(ADRD)的老年人维持生活质量 通过提供创新的、基于证据的、在线的、直播的、团体的项目,我们的第一 Together音频/视频平台上的产品是Moving TogetherTM,它结合了动作, 通过正念身体意识练习和社交活动支持日常功能,旨在 轻度ADRD患者及其护理人员在家一起参与。其主要目标是 第二阶段小企业创新研究(SBIR)赠款是扩大我们的产品线, 并为轻度认知障碍患者测试一项全面的大脑健康计划, 损害(MCI)。这一目标代表了我们公司从公众和 健康和商业前景。患有MCI的老年人代表了一个巨大的市场,具有重要的未满足的需求: 大约20%的老年人(> 270万美国人)目前患有MCI,这使他们在 发展ADRD的风险增加。没有药物可以预防ADRD的发展, MCI患者;然而,越来越多的证据表明,针对可改变的 痴呆症的危险因素--如缺乏运动、社交孤立和抑郁--可能有助于改善 认知功能,并可能延迟痴呆症的发作。我们的初步结果表明,我们的产品, 一起运动与认知功能,身体功能,社交功能, 隔离和自我调节以及静息状态前/后增加的默认模式网络连接 功能性磁共振成像(rs-fMRI)扫描与MCI的人。我们相信这些好处 如果“一起行动”与全面的大脑健康指导相结合, 程序.因此,我们的具体目标是:1)与我们的科学顾问委员会合作, 以人为本的设计,为为期12周,以小组为基础, 直播,数字节目,将联合收割机一起移动与大脑健康教练,以解决 MCI患者中可改变的痴呆风险因素; 2)进行随机对照试验,以确定 脑健康共同计划是否在12周内改善MCI患者的认知功能 与成功老化对照组相比;以及3)确定每周维护课程是否 在干预后的12周内,帮助维持大脑健康计划的效果。如果我们能 证明大脑健康在以下方面具有立即和持续的认知益处: 与MCI的人,它将共同定位为循证计划的国家领导者, 提高生活质量并防止患有认知障碍的老年人的衰退。

项目成果

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Deborah E. Barnes其他文献

English- and Spanish-Speaking Vulnerable Older Adults Report Many Unique Barriers to Advance Care Planning (W215A)
  • DOI:
    10.1016/j.jpainsymman.2021.01.015
  • 发表时间:
    2021-03-01
  • 期刊:
  • 影响因子:
  • 作者:
    Linda H. Phung;Deborah E. Barnes;Aiesha M. Volow;Nikita R. Shirsat;Rebecca L. Sudore
  • 通讯作者:
    Rebecca L. Sudore
Erratum to: ‘The advance care planning PREPARE study among older Veterans with serious and chronic illness: study protocol for a randomized controlled trial’
  • DOI:
    10.1186/s13063-016-1182-y
  • 发表时间:
    2016-01-20
  • 期刊:
  • 影响因子:
    2.000
  • 作者:
    Rebecca Sudore;Gem M. Le;Ryan McMahan;Mariko Feuz;Mary Katen;Deborah E. Barnes
  • 通讯作者:
    Deborah E. Barnes
VA Symposium: Links to Dementia
  • DOI:
    10.1016/j.jagp.2012.12.079
  • 发表时间:
    2013-03-01
  • 期刊:
  • 影响因子:
  • 作者:
    Marie A. DeWitt;Deborah E. Barnes;Mark E. Kunik;Sharon M. Gordon
  • 通讯作者:
    Sharon M. Gordon
Implementing a new multidisciplinary, remote, dementia staff training program for Veterans affairs nursing homes
  • DOI:
    10.1186/s12913-024-11464-4
  • 发表时间:
    2024-10-03
  • 期刊:
  • 影响因子:
    3.000
  • 作者:
    Nikita R. Shirsat;Jennifer Ann Lee;Catherine Pham;Matthew J. Miller;Margaret A. Chesney;Francesca M. Nicosia;Linda Chao;Deborah E. Barnes
  • 通讯作者:
    Deborah E. Barnes
Scientific quality of original research articles on environmental tobacco smoke
关于环境烟草烟雾的原创研究文章的科学质量
  • DOI:
    10.1136/tc.6.1.19
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Deborah E. Barnes;L. Bero
  • 通讯作者:
    L. Bero

Deborah E. Barnes的其他文献

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{{ truncateString('Deborah E. Barnes', 18)}}的其他基金

A Novel Algorithm to Identify People with Undiagnosed Alzheimer's Disease and Related Dementias
一种识别未确诊阿尔茨海默病和相关痴呆症患者的新算法
  • 批准号:
    10696912
  • 财政年份:
    2023
  • 资助金额:
    $ 150.5万
  • 项目类别:
BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM
共同促进大脑健康:基于小组的直播数字节目
  • 批准号:
    10747235
  • 财政年份:
    2021
  • 资助金额:
    $ 150.5万
  • 项目类别:
BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM
共同促进大脑健康:基于小组的直播数字节目
  • 批准号:
    10493302
  • 财政年份:
    2021
  • 资助金额:
    $ 150.5万
  • 项目类别:
Identifying and supporting patients with undiagnosed dementia using the EHR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR): a pilot clinical trial
使用 EHR 阿尔茨海默氏症和痴呆症风险评估规则 (eRADAR) 识别和支持未确诊的痴呆症患者:一项试点临床试验
  • 批准号:
    10409614
  • 财政年份:
    2020
  • 资助金额:
    $ 150.5万
  • 项目类别:
EXTENDING INDEPENDENCE AND QUALITY OF LIFE FOR PEOPLE WITH ALZHEIMER'S DISEASE OR DEMENTIA THROUGH TELEHEALTH PROGRAM DELIVERY
通过远程医疗计划的实施,提高阿尔茨海默病或痴呆症患者的独立性和生活质量
  • 批准号:
    10204865
  • 财政年份:
    2020
  • 资助金额:
    $ 150.5万
  • 项目类别:
Identifying and supporting patients with undiagnosed dementia using the EHR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR): a pilot clinical trial
使用 EHR 阿尔茨海默氏症和痴呆症风险评估规则 (eRADAR) 识别和支持未确诊的痴呆症患者:一项试点临床试验
  • 批准号:
    10665566
  • 财政年份:
    2020
  • 资助金额:
    $ 150.5万
  • 项目类别:
EXTENDING INDEPENDENCE AND QUALITY OF LIFE FOR PEOPLE WITH ALZHEIMER'S DISEASE OR DEMENTIA THROUGH TELEHEALTH PROGRAM DELIVERY
通过远程医疗计划的实施,提高阿尔茨海默病或痴呆症患者的独立性和生活质量
  • 批准号:
    10019891
  • 财政年份:
    2020
  • 资助金额:
    $ 150.5万
  • 项目类别:
Identifying and supporting patients with undiagnosed dementia using the EHR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR): a pilot clinical trial
使用 EHR 阿尔茨海默氏症和痴呆症风险评估规则 (eRADAR) 识别和支持未确诊的痴呆症患者:一项试点临床试验
  • 批准号:
    10213652
  • 财政年份:
    2020
  • 资助金额:
    $ 150.5万
  • 项目类别:
Low-cost detection of dementia using electronic health records data: validation and testing of the eRADAR algorithm in a pragmatic, patient-centered trial.
使用电子健康记录数据低成本检测痴呆症:在务实、以患者为中心的试验中验证和测试 eRADAR 算法。
  • 批准号:
    10266125
  • 财政年份:
    2020
  • 资助金额:
    $ 150.5万
  • 项目类别:
Low-cost detection of dementia using electronic health records data: validation and testing of the eRADAR algorithm in a pragmatic, patient-centered trial.
使用电子健康记录数据低成本检测痴呆症:在务实、以患者为中心的试验中验证和测试 eRADAR 算法。
  • 批准号:
    10443874
  • 财政年份:
    2020
  • 资助金额:
    $ 150.5万
  • 项目类别:

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