NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) ADMINISTRATIVE COORDINATING CENTER (ACC)

NHLBI 精准医学转录组学 (TOPMED) 行政协调中心 (ACC)

• 批准号: 10505553
• 负责人: PATRICIA SHIFFLETT
• 金额: $ 207.42万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-23 至 2022-08-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10505553
• 关键词: Clinical Research; Cohort Studies; Communication; Data; Goals; Heart Diseases; Hematological Disease; Individual; Knowledge; Lung diseases; Maintenance; Manuals; National Heart, Lung, and Blood Institute; Phenotype; Proteome; Publications; Research Personnel; Sleep Disorders; Trans-Omics for Precision Medicine; data resource; genome sequencing; genomic data; improved; metabolome; methylome; multiple omics; operation; precision medicine; programs; transcriptome sequencing; website development; whole genome; working group

The goal of the National Heart, Lung, and Blood Institute’s (NHLBI) Trans-Omics for Precision Medicine (TOPMed) program is to generate large scale genomic data resources that will enable investigators to generate new knowledge to improve the understanding of heart, lung, blood, and sleep disorders and advance precision medicine of related conditions. The TOPMed program was initiated in 2014, has generated whole genome sequencing data (WGS) for over 160,000 individuals, and will soon exceed 100,000 assessments of multi-Omics (RNA-seq, methylome, metabolome, and proteome) data. TOPMed spans more than 90 NHLBI cohorts and clinical studies, over 1,000 investigators, 32 phenotype-focused working groups, 10 committees, and 4 sequencing centers.

国家心、肺和血液研究所(NHLBI)精密医学反式组学(TOPMed)计划的目标是生成大规模基因组数据资源，使研究人员能够生成新知识，以提高对心、肺、血液和睡眠障碍的理解，并推进相关疾病的精确医学。TOPMed计划于2014年启动，已为超过160,000个个体生成了全基因组测序数据(WGS)，并将很快超过100,000个多Omics(RNA-Seq、甲基组、代谢组和蛋白质组)数据的评估。TOPMed涵盖了90多个NHLBI队列和临床研究、1000多名研究人员、32个专注于表型的工作组、10个委员会和4个测序中心。