NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) ADMINISTRATIVE COORDINATING CENTER (ACC)

国家心脏，肺和血液研究所（NHLBI）的Trans-Omics for Precision Medicine（TOPMed）计划的目标是生成大规模的基因组数据资源，使研究人员能够生成新的知识，以提高对心脏，肺，血液和睡眠障碍的理解，并推进相关疾病的精准医学。TOPMed计划于2014年启动，已为超过160，000人生成全基因组测序数据（WGS），并将很快超过100，000个多组学（RNA-seq，甲基化组，代谢组和蛋白质组）数据评估。 TOPMed涵盖90多个NHLBI队列和临床研究，超过1，000名研究人员，32个以表型为重点的工作组，10个委员会和4个测序中心。

The goal of the National Heart, Lung, and Blood Institute’s (NHLBI) Trans-Omics for Precision Medicine (TOPMed) program is to generate large scale genomic data resources that will enable investigators to generate new knowledge to improve the understanding of heart, lung, blood, and sleep disorders and advance precision medicine of related conditions. The TOPMed program was initiated in 2014, has generated whole genome sequencing data (WGS) for over 160,000 individuals, and will soon exceed 100,000 assessments of multi-Omics (RNA-seq, methylome, metabolome, and proteome) data. TOPMed spans more than 90 NHLBI cohorts and clinical studies, over 1,000 investigators, 32 phenotype-focused working groups, 10 committees, and 4 sequencing centers.