PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education)

PASSCODE（胰腺腺癌基质重编程联盟协调、数据管理和教育）

• 批准号: 10517527
• 负责人: J. Jack LEE
• 金额: $ 97.2万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517527
• 关键词: American; American Cancer Society; Area; Basic Science; Bioinformatics; Biological Assay; Biometry; Cancer Biology; Cancer Etiology; Cataloging; Cells; Characteristics; Clinical; Clinical Trials Design; Collaborations; Communication; Communities; Computational Biology; Cues; Data; Data Collection; Data Science; Data Storage and Retrieval; Desmoplastic; Diagnosis; Disease; Disease Outcome; Ecosystem; Education; Educational Activities; Educational workshop; Elements; Ensure; Extracellular Matrix; Facility Accesses; Fibroblasts; Funding; Genetic; Goals; Group Meetings; Growth; Heterogeneity; Immune; Infrastructure; Intranet; Logistics; Lymphovascular; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentorship; Mission; Molecular; Outcome; Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patients; Persons; Play; Policies; Procedures; Reagent; Registries; Regulation; Research; Research Activity; Research Personnel; Role; Secure; Short Interspersed Nucleotide Elements; Site; Site Visit; Solid; Specificity; Stromal Neoplasm; System; Therapeutic; Time; Tissues; Transfer Agreement; Translational Research; Twitter; Underrepresented Minority; United States; United States National Institutes of Health; analytical tool; base; biobank; cancer genetics; cloud based; computing resources; data dissemination; data exchange; data harmonization; data management; improved; innovation; material transfer agreement; meetings; member; minority trainee; molecular pathology; mortality; multidisciplinary; multimodal data; neoplastic cell; outreach; pancreas visualization; pancreatic tumorigenesis; programs; research study; response; shared database; social media; success; survival outcome; symposium; tumor; tumor immunology; tumor microbiome; tumor microenvironment; virtual; web site; working group

ABSTRACT A defining feature of Pancreatic ductal adenocarcinoma (PDAC) is the presence of a host stromal response, which is characteristically more robust (“desmoplastic”) than many solid cancers. Stromal elements, including cancer-associated fibroblasts (CAFs) and the extracellular matrix, are pivotal components of the tumor microenvironment (TME) ecosystem in PDAC, which also includes immune cells, the lymphovascular system, and the intra-tumoral microbiome. In recent years the role of the PDAC stroma (and CAFs, in particular) has morphed to one characterized by profound heterogeneity, plasticity, and context-specificity. The newly created Pancreatic Cancer Stromal Reprogramming Consortium (PSRC) will fund a team of six U01 sites to conduct basic and translational research studies on the role of the stroma and other TME constituents in PDAC pathogenesis and outcomes. We have collated a multidisciplinary team of investigators at UT MD Anderson with the goal of creating PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education Center), that will serve as an organizing “hub” for coordination, communication and collaboration within the PSRC, and support the newly funded U01 sites. PASSCODE will be co-led by Dr. Anirban Maitra, an expert in PDAC pathology, genetics, and cancer biology, and Dr. J. Jack Lee, an expert in biostatistics, clinical trial design and data science. PASSCODE proposes four aims: First, we will support the administrative infrastructure of the PSRC, and ensure effective communication and collaboration between consortium investigators, the NCI program office and other trans-NCI networks, including facilitating all of the PSRC-approved in-person and virtual meetings. We will also provide operational support for material and data transfer agreements that are germane to the collaborative studies within the PSRC. Second, we will develop a framework for a PSRC “virtual biorepository” as a registry database for shared biospecimen access across the consortium, and develop SOPs for processing, storage, cataloging, and distribution of annotated biospecimens and de-identified clinical, demographic, and molecular information. Third, we will provide centralized data management and data storage capabilities for the PSRC, with the overarching goal of data harmonization and dissemination, within and beyond the consortium. As part of this aim, PASSCODE will provide dedicated biostatistical and bioinformatics analytical tools, and multimodal data visualization for PSRC investigators, including for approved collaborative projects. Fourth, PASSCODE will be responsible for developing and maintaining both a “public facing” PSRC website and other social media outlets, as well as a secure intranet site. We will organize seminars and workshops that highlight progress within the PSRC, and provide a platform for educational/mentorship opportunities, especially with regards to enhancing the participation of underrepresented minority trainees. Cumulatively, PASSCODE’s activities will be geared towards ensuring the success of the consortium’s mission of improving PDAC survival through innovative and collaborative research endeavors.

摘要 胰腺导管腺癌（PDAC）的一个定义特征是存在宿主间质反应， 其特征性地比许多实体癌更强健（“促结缔组织增生”）。基质成分，包括 癌相关成纤维细胞（CAF）和细胞外基质是肿瘤的关键成分 PDAC中的微环境（TME）生态系统，其中还包括免疫细胞，淋巴血管系统， 和肿瘤内的微生物组。近年来，PDAC基质（特别是CAF）的作用已被证实。 演变为一个具有深刻的异质性，可塑性和上下文特异性的特点。新创建的 胰腺癌基质重编程联盟（PSRC）将资助一个由六个U 01研究中心组成的团队， PDAC中基质和其他TME成分作用的基础和转化研究 发病机制和结果。我们整理了UT MD安德森的多学科研究团队， 创建PASSCODE（胰腺癌基质重编程联合体）的目的 协调、数据管理和教育中心），将作为协调的组织“中心”， PSRC内部的沟通和协作，并支持新资助的U 01站点。PASSCODE将成为 由PDAC病理学、遗传学和癌症生物学专家Anirban Maitra博士和J. Jack Lee博士共同领导， 生物统计学、临床试验设计和数据科学专家。PASSCODE提出了四个目标：第一，我们将 支持PSRC的行政基础设施，并确保有效的沟通和协作 联盟调查人员、NCI项目办公室和其他跨NCI网络之间的联系，包括促进所有 PSRC批准的面对面和虚拟会议。我们还将提供物资和 与PSRC内的合作研究密切相关的数据传输协议。第二，我们将发展 一个PSRC“虚拟生物库”框架，作为跨区域共享生物标本访问的注册数据库。 联合体，并制定标准操作规程，用于处理、储存、编目和分发带注释的生物标本 以及去识别的临床、人口统计学和分子信息。第三，我们将提供集中的数据 PSRC的管理和数据存储能力，其总体目标是数据协调和 在联合体内外传播。作为这一目标的一部分，PASSCODE将提供专门的 生物统计和生物信息学分析工具，以及PSRC研究人员的多模式数据可视化， 包括已批准的合作项目。第四，PASSCODE将负责开发和 维持一个“面向公众”的PSRC网站和其他社交媒体渠道，以及一个安全的内联网网站。 我们将举办研讨会和讲习班，重点介绍私营部门改革委员会的进展，并提供一个平台， 教育/指导机会，特别是在加强任职人数不足的人的参与方面 少数民族学员。PASSCODE的活动将逐步面向确保 联盟的使命，提高PDAC生存通过创新和合作研究的努力。