PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education)

PASSCODE（胰腺腺癌基质重编程联盟协调、数据管理和教育）

• 批准号: 10517527
• 负责人: J. Jack LEE
• 金额: $ 97.2万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517527
• 关键词: American; American Cancer Society; Area; Basic Science; Bioinformatics; Biological Assay; Biometry; Cancer Biology; Cancer Etiology; Cataloging; Cells; Characteristics; Clinical; Clinical Trials Design; Collaborations; Communication; Communities; Computational Biology; Cues; Data; Data Collection; Data Science; Data Storage and Retrieval; Desmoplastic; Diagnosis; Disease; Disease Outcome; Ecosystem; Education; Educational Activities; Educational workshop; Elements; Ensure; Extracellular Matrix; Facility Accesses; Fibroblasts; Funding; Genetic; Goals; Group Meetings; Growth; Heterogeneity; Immune; Infrastructure; Intranet; Logistics; Lymphovascular; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentorship; Mission; Molecular; Outcome; Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patients; Persons; Play; Policies; Procedures; Reagent; Registries; Regulation; Research; Research Activity; Research Personnel; Role; Secure; Short Interspersed Nucleotide Elements; Site; Site Visit; Solid; Specificity; Stromal Neoplasm; System; Therapeutic; Time; Tissues; Transfer Agreement; Translational Research; Twitter; Underrepresented Minority; United States; United States National Institutes of Health; analytical tool; base; biobank; cancer genetics; cloud based; computing resources; data dissemination; data exchange; data harmonization; data management; improved; innovation; material transfer agreement; meetings; member; minority trainee; molecular pathology; mortality; multidisciplinary; multimodal data; neoplastic cell; outreach; pancreas visualization; pancreatic tumorigenesis; programs; research study; response; shared database; social media; success; survival outcome; symposium; tumor; tumor immunology; tumor microbiome; tumor microenvironment; virtual; web site; working group

ABSTRACT A defining feature of Pancreatic ductal adenocarcinoma (PDAC) is the presence of a host stromal response, which is characteristically more robust (“desmoplastic”) than many solid cancers. Stromal elements, including cancer-associated fibroblasts (CAFs) and the extracellular matrix, are pivotal components of the tumor microenvironment (TME) ecosystem in PDAC, which also includes immune cells, the lymphovascular system, and the intra-tumoral microbiome. In recent years the role of the PDAC stroma (and CAFs, in particular) has morphed to one characterized by profound heterogeneity, plasticity, and context-specificity. The newly created Pancreatic Cancer Stromal Reprogramming Consortium (PSRC) will fund a team of six U01 sites to conduct basic and translational research studies on the role of the stroma and other TME constituents in PDAC pathogenesis and outcomes. We have collated a multidisciplinary team of investigators at UT MD Anderson with the goal of creating PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education Center), that will serve as an organizing “hub” for coordination, communication and collaboration within the PSRC, and support the newly funded U01 sites. PASSCODE will be co-led by Dr. Anirban Maitra, an expert in PDAC pathology, genetics, and cancer biology, and Dr. J. Jack Lee, an expert in biostatistics, clinical trial design and data science. PASSCODE proposes four aims: First, we will support the administrative infrastructure of the PSRC, and ensure effective communication and collaboration between consortium investigators, the NCI program office and other trans-NCI networks, including facilitating all of the PSRC-approved in-person and virtual meetings. We will also provide operational support for material and data transfer agreements that are germane to the collaborative studies within the PSRC. Second, we will develop a framework for a PSRC “virtual biorepository” as a registry database for shared biospecimen access across the consortium, and develop SOPs for processing, storage, cataloging, and distribution of annotated biospecimens and de-identified clinical, demographic, and molecular information. Third, we will provide centralized data management and data storage capabilities for the PSRC, with the overarching goal of data harmonization and dissemination, within and beyond the consortium. As part of this aim, PASSCODE will provide dedicated biostatistical and bioinformatics analytical tools, and multimodal data visualization for PSRC investigators, including for approved collaborative projects. Fourth, PASSCODE will be responsible for developing and maintaining both a “public facing” PSRC website and other social media outlets, as well as a secure intranet site. We will organize seminars and workshops that highlight progress within the PSRC, and provide a platform for educational/mentorship opportunities, especially with regards to enhancing the participation of underrepresented minority trainees. Cumulatively, PASSCODE’s activities will be geared towards ensuring the success of the consortium’s mission of improving PDAC survival through innovative and collaborative research endeavors.

摘要 胰腺导管腺癌(PDAC)的一个明显特征是存在宿主间质反应， 它的特点是比许多实体癌更强壮(“促结缔组织增生性”)。基质元素，包括 肿瘤相关成纤维细胞(CAF)和细胞外基质是肿瘤的关键成分 PDAC的微环境(TME)生态系统，其中还包括免疫细胞、淋巴血管系统、 以及肿瘤内的微生物群。近年来，PDAC基质(尤其是CAF)的作用已经 演变成一种具有深刻的异质性、可塑性和上下文特殊性的特征。新创建的 胰腺癌间质重编程联盟(PSRC)将资助一个由六个U01站点组成的团队进行 基质和其他TME成分在PDAC中作用的基础和翻译研究 发病机制和转归。我们已经将UT MD Anderson的一个多学科调查团队与 创建PASSWODE(胰腺癌间质再编程联盟)的目标 协调、数据管理和教育中心)，将作为协调的组织“枢纽”， 在PSRC内进行沟通和协作，并支持新资助的U01站点。密码将是 由PDAC病理学、遗传学和癌症生物学专家Anirban Maitra博士和J.Jack Lee博士共同领导， 生物统计学、临床试验设计和数据科学方面的专家。密码提出了四个目标：第一，我们将 支持PSRC的行政基础设施，并确保有效的沟通和协作 在财团调查人员、NCI方案办公室和其他跨NCI网络之间，包括促进所有 PSRC批准的面对面会议和虚拟会议。我们还将提供运营支持的材料和 与PSRC内的合作研究密切相关的数据传输协议。第二，我们将发展 作为注册数据库的PSRC“虚拟生物资源库”的框架，用于跨 联盟，并开发用于加工、存储、编目和分发带注释的生物标本的SOP 以及未识别的临床、人口统计学和分子信息。第三，我们将提供集中的数据 为PSRC提供管理和数据存储能力，总体目标是统一数据和 在财团内部和之外进行传播。作为这一目标的一部分，密码将提供专门的 生物统计和生物信息学分析工具，以及PSRC调查人员的多模式数据可视化， 包括已批准的协作项目。第四，Passcode将负责开发和 维持一个“面向公众”的PSRC网站和其他社交媒体渠道，以及一个安全的内联网网站。 我们将组织研讨会和讲习班，突出PSRC内部的进展，并为 教育/辅导机会，特别是在加强任职人数不足的人的参与方面 少数族裔实习生。总而言之，Passcode的活动将面向确保成功 财团的使命是通过创新和合作的研究努力改善PDAC的生存。