Core 3-Biostatistics

核心3-生物统计学

• 批准号: 10415937
• 负责人: J. Jack LEE
• 金额: $ 26.28万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-16 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415937
• 关键词: Address; Adopted; Algorithms; Animal Model; Award; Bioconductor; Bioinformatics; Biological Markers; Biometry; Cancer Center; Cell Line; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Code; Complex; Computer Analysis; Conduct Clinical Trials; Confidentiality of Patient Information; Data; Data Analyses; Databases; Development; Ensure; Epidemiology; Experimental Designs; Genomics; Human Resources; Immunologics; Laboratories; Libraries; Link; Manuscripts; Methods; Pathology; Patients; Phase; Play; Proteomics; Publications; Reporting; Research; Research Personnel; Research Project Grants; Resources; Role; Services; Statistical Data Interpretation; Statistical Methods; Structure; Technology; University of Texas M D Anderson Cancer Center; base; bioinformatics resource; biomarker discovery; career; clinical database; data management; design; experimental study; genome analysis; genomic data; high dimensionality; innovation; laboratory experiment; meetings; melanoma; member; novel; open source; pre-clinical; predictive marker; programs; sound; tissue resource; tool; translational study; trial design; web-accessible

Core 3: Project Summary/Abstract The Biostatistics and Bioinformatics Core 3 provides comprehensive service to guide design of experiments, to optimize quantitative data analysis, and to maintain statistical justification and interpretation of results. Specifically, Core 3 will implement sound experimental design principles that are tailored to address specific scientific questions for each project. Core 3 will also carry out data analyses using suitable statistical methods and bioinformatics algorithms, and will contribute to the interpretation of results through written reports and frequent interactions with project investigators. Whenever appropriate, Core 3 will develop new analysis tools to address new challenges in the analysis of various data, especially high-throughput genomic and proteomic data. Members of Core 3 will participate in monthly SPORE meetings with all project investigators, ensuring that statistical and data analysis/management issues are carefully considered during all phases of each SPORE experiment. Thus, from inception to reporting and publication, basic laboratory and translational experiments will benefit from the SPORE program that will be used to augment existing MD Anderson Cancer Center biostatistics resources.

核心 3：项目总结/摘要 生物统计学和生物信息学核心 3 提供全面的服务来指导设计 实验，优化定量数据分析，并保持统计合理性和解释 结果。具体来说，Core 3 将实施健全的实验设计原则，旨在解决 每个项目的具体科学问题。 Core 3 还将使用适当的统计方法进行数据分析 方法和生物信息学算法，并将通过书面形式有助于结果的解释 报告以及与项目调查人员的频繁互动。在适当的时候，Core 3 将开发新的 分析工具可应对各种数据分析中的新挑战，特别是高通量基因组数据 和蛋白质组数据。 Core 3 的成员将参加所有项目的每月 SPORE 会议 调查人员，确保在调查过程中仔细考虑统计和数据分析/管理问题 每个 SPORE 实验的所有阶段。因此，从开始到报告和出版，基础实验室 转化实验将受益于 SPORE 计划，该计划将用于增强现有的 MD 安德森癌症中心生物统计资源。