PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education)

PASSCODE(胰腺腺癌基质重编程联盟协调、数据管理和教育)

基本信息

  • 批准号:
    10705730
  • 负责人:
  • 金额:
    $ 97.2万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-16 至 2027-08-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT A defining feature of Pancreatic ductal adenocarcinoma (PDAC) is the presence of a host stromal response, which is characteristically more robust (“desmoplastic”) than many solid cancers. Stromal elements, including cancer-associated fibroblasts (CAFs) and the extracellular matrix, are pivotal components of the tumor microenvironment (TME) ecosystem in PDAC, which also includes immune cells, the lymphovascular system, and the intra-tumoral microbiome. In recent years the role of the PDAC stroma (and CAFs, in particular) has morphed to one characterized by profound heterogeneity, plasticity, and context-specificity. The newly created Pancreatic Cancer Stromal Reprogramming Consortium (PSRC) will fund a team of six U01 sites to conduct basic and translational research studies on the role of the stroma and other TME constituents in PDAC pathogenesis and outcomes. We have collated a multidisciplinary team of investigators at UT MD Anderson with the goal of creating PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education Center), that will serve as an organizing “hub” for coordination, communication and collaboration within the PSRC, and support the newly funded U01 sites. PASSCODE will be co-led by Dr. Anirban Maitra, an expert in PDAC pathology, genetics, and cancer biology, and Dr. J. Jack Lee, an expert in biostatistics, clinical trial design and data science. PASSCODE proposes four aims: First, we will support the administrative infrastructure of the PSRC, and ensure effective communication and collaboration between consortium investigators, the NCI program office and other trans-NCI networks, including facilitating all of the PSRC-approved in-person and virtual meetings. We will also provide operational support for material and data transfer agreements that are germane to the collaborative studies within the PSRC. Second, we will develop a framework for a PSRC “virtual biorepository” as a registry database for shared biospecimen access across the consortium, and develop SOPs for processing, storage, cataloging, and distribution of annotated biospecimens and de-identified clinical, demographic, and molecular information. Third, we will provide centralized data management and data storage capabilities for the PSRC, with the overarching goal of data harmonization and dissemination, within and beyond the consortium. As part of this aim, PASSCODE will provide dedicated biostatistical and bioinformatics analytical tools, and multimodal data visualization for PSRC investigators, including for approved collaborative projects. Fourth, PASSCODE will be responsible for developing and maintaining both a “public facing” PSRC website and other social media outlets, as well as a secure intranet site. We will organize seminars and workshops that highlight progress within the PSRC, and provide a platform for educational/mentorship opportunities, especially with regards to enhancing the participation of underrepresented minority trainees. Cumulatively, PASSCODE’s activities will be geared towards ensuring the success of the consortium’s mission of improving PDAC survival through innovative and collaborative research endeavors.
摘要

项目成果

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J. Jack LEE其他文献

J. Jack LEE的其他文献

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{{ truncateString('J. Jack LEE', 18)}}的其他基金

PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education)
PASSCODE(胰腺腺癌基质重编程联盟协调、数据管理和教育)
  • 批准号:
    10517527
  • 财政年份:
    2022
  • 资助金额:
    $ 97.2万
  • 项目类别:
Core 3-Biostatistics
核心3-生物统计学
  • 批准号:
    10415937
  • 财政年份:
    2019
  • 资助金额:
    $ 97.2万
  • 项目类别:
Core 3-Biostatistics
核心3-生物统计学
  • 批准号:
    10208807
  • 财政年份:
    2019
  • 资助金额:
    $ 97.2万
  • 项目类别:
Core 3-Biostatistics
核心3-生物统计学
  • 批准号:
    10683945
  • 财政年份:
    2019
  • 资助金额:
    $ 97.2万
  • 项目类别:
CB: Biostatistics and Data Management Core
CB:生物统计学和数据管理核心
  • 批准号:
    7510714
  • 财政年份:
    2008
  • 资助金额:
    $ 97.2万
  • 项目类别:
BIOSTATISTICS AND DATA MANAGEMENT CORE
生物统计和数据管理核心
  • 批准号:
    6990042
  • 财政年份:
    2004
  • 资助金额:
    $ 97.2万
  • 项目类别:
10 Biostatistics Resource Group
10 生物统计资源组
  • 批准号:
    10655517
  • 财政年份:
    1996
  • 资助金额:
    $ 97.2万
  • 项目类别:
10 Biostatistics Resource Group
10 生物统计资源组
  • 批准号:
    10212258
  • 财政年份:
    1996
  • 资助金额:
    $ 97.2万
  • 项目类别:
10 Biostatistics Resource Group
10 生物统计资源组
  • 批准号:
    10466990
  • 财政年份:
    1996
  • 资助金额:
    $ 97.2万
  • 项目类别:
CB: Biostatistics and Data Management Core
CB:生物统计学和数据管理核心
  • 批准号:
    8119675
  • 财政年份:
  • 资助金额:
    $ 97.2万
  • 项目类别:

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  • 批准号:
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    7402259
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