10 Biostatistics Resource Group

项目摘要：生物统计学资源组（BRG） 生物统计学资源组（BRG）的使命是提高医学博士研究的科学卓越性 安德森通过杰出的统计设计和方法，包括正确和有效地使用标准 和先进的方法和新方法的开发;并培训和指导未来的生物统计学家 通过创新的，相关的课程，并通过接触独特的数据集，最新的研究 方法和调查结果，以及最先进的计算技术。BRG教师导师博士后研究员 并参加3个正式的博士学位课程，教学课程和指导研究生研究人员：（i） MD Anderson-UTHealth生物医学科学研究生院的定量科学;（ii）机构间 癌症研究生物统计学研究生课程，与赖斯统计系共同努力 大学;及（iii）与德克萨斯A&M大学的共同努力。导演J. Jack Lee博士和联合导演Yu博士 Shen和Marcella约翰逊女士领导BRG，这有助于该机构的严谨性和可重复性 对提交科学审查的所有临床和研究方案进行每周共识审查（除 事先获得NIH批准的和直接提交给机构审查委员会[IRB]的）， 在MD安德森发起的所有临床试验的设计中，进行数据分析，并进行以下操作 促进再现性的程序。BRG在一个独立的定量科学团体中的地位 确保对研究的客观评价。一名教师和统计分析师团队被分配为 机构内每个研究和临床部门的主要联系人， 在指定的团队中进行协作和提供主题方面的专业知识。方案和试验在 由IRB审查，以保护MD安德森的科学完整性和患者护理质量， 实验动物使用。所有BRG教职员工和统计分析师都可以合作或咨询 与临床和实验室研究人员合作。BRG通过（i）贝叶斯方法提供附加值 推理，临床试验中的自适应随机化，以及统计和图形建模;（ii）临床试验 进行，集中收集BRG设计的数据库、Web应用程序和Web服务，支持 进行临床试验;及（iii）支持临床试验管理的软件程序， 记录下来，并免费在线分发给世界各地的研究人员。在过去的六年里，BRG 支持了1,097名中心成员，他们代表CCSG的所有项目，并为1500多篇论文做出了贡献， 577例（38%）IF >5，175例（11%）IF >10。在补助金Yr 42，BRG利用率增加了20%， 前5年的平均水平，同行评审资助的使用占77%。在第43年， 贡献了BRG运营费用总额的44%（3，337，751美元）;其他拨款占48% （3，697，124美元），CCSG资金提供了8%（611，160美元）。对于44年，BRG要求629,456美元（增加3%， 但BRG运营费用总额的7%）。

PROJECT SUMMARY: BIOSTATISTICS RESOURCE GROUP (BRG) The mission of the Biostatistics Resource Group (BRG) is to enhance the scientific excellence of research at MD Anderson through outstanding statistical designs and methods, including the proper and efficient use of standard and cutting-edge methods and the development of novel methods; and to train and mentor future biostatisticians through an innovative, relevant curriculum and through exposure to unique data sets, the latest research methodology and findings, and state-of-the-art computing technology. BRG faculty mentor postdoctoral fellows and participate in 3 formal doctoral degree programs, teaching courses and advising graduate researchers: (i) Quantitative Sciences at MD Anderson-UTHealth Graduate School of Biomedical Sciences; (ii) Interinstitutional Graduate Program in Biostatistics for Cancer Research, a joint effort with the Department of Statistics at Rice University; and (iii) a joint effort with Texas A&M University. Director Dr. J. Jack Lee and co-directors Dr. Yu Shen and Ms. Marcella Johnson lead the BRG, which contributes to rigor and reproducibility at the institution by holding weekly consensus reviews of all clinical and research protocols submitted for scientific review (except those with prior NIH approval and those submitted directly to the institutional review board [IRB]), collaborating in the design of all clinical trials initiated at MD Anderson, conducting the data analyses, and following operating procedures that facilitate reproducibility. The status of the BRG within an independent, quantitative science group ensures the objective assessment of research. A faculty member and statistical analyst team are assigned as the primary contacts for each research and clinical department within the institution, which fosters close collaboration and subject matter expertise within the assigned teams. Protocols and trials are evaluated before they are reviewed by the IRB to protect the scientific integrity of MD Anderson and the quality of patient care and laboratory animal use. All BRG faculty members and statistical analysts are available to collaborate or consult with clinical and laboratory-based researchers. The BRG provides added value through (i) Bayesian approaches to inference, adaptive randomization in clinical trials, and statistical and graphical modeling; (ii) Clinical Trial Conduct, a centralized collection of BRG-designed databases, web applications, and web services that support the conduct of clinical trials; and (iii) software programs to support clinical trial management, which are documented and distributed online to researchers around the world at no cost. During the past 6 years, the BRG supported 1,097 center members representing all CCSG programs and contributed to more than 1500 papers, 577 (38%) with IF >5 and 175 (11%) with IF >10. In grant Yr42, BRG utilization increased 20% compared with the previous 5-year average, and peer review-funded usage accounted for 77%. In Yr43, the institution contributed 44% ($3,337,751) of the total BRG operating expenses; other grant allocations covered 48% ($3,697,124), and CCSG funds provided 8% ($611,160). For Yr44, the BRG requests $629,456 (a 3% increase, but 7% of the total BRG operating expenses) from the CCSG.