10 Biostatistics Resource Group

10 生物统计资源组

• 批准号: 10212258
• 负责人: J. Jack LEE
• 金额: $ 97.05万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-28 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212258
• 关键词: Adopted; Basic Science; Bayesian Method; Behavioral; Biometry; Cancer Center; Cancer Center Support Grant; Clinic; Clinical; Clinical Research; Clinical Research Protocols; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials Design; Collaborations; Collection; Complex; Computer software; Conduct Clinical Trials; Consensus; Consult; Consultations; Continuing Education; Data; Data Analyses; Data Set; Degree program; Development; Doctor' s Degree; Drops; Early Diagnosis; Educational Curriculum; Educational process of instructing; Educational workshop; Ensure; Exposure to; Faculty; Fostering; Funding; Futility; Future; Goals; Grant; Health Services Research; IACUC; Information Technology; Institution; Institutional Review Boards; Joints; Knowledge; Laboratories; Laboratory Animals; Lead; Malignant Neoplasms; Mentors; Methods; Mission; Modeling; Monitor; Moon; Paper; Patient Care; Patient Recruitments; Peer Review; Phase; Postdoctoral Fellow; Prevention; Procedures; Protocols documentation; Randomized; Reproducibility; Research; Research Methodology; Research Personnel; Research Training; Resources; Rice; Sample Size; Schedule; Schools; Science; Scientist; Services; Statistical Methods; Structure; Support Groups; Technology; Texas; Time; Toxic effect; Training; Training Programs; Training and Education; Translational Research; United States National Institutes of Health; Universities; analytical method; anticancer research; base; behavioral health; cancer prevention; cost; database design; design; faculty mentor; graduate student; improved; innovation; lectures; member; method development; next generation; novel; outreach; patient safety; precision oncology; programs; psychosocial; skills; statistics; training opportunity; web app; web services

PROJECT SUMMARY: BIOSTATISTICS RESOURCE GROUP (BRG) The mission of the Biostatistics Resource Group (BRG) is to enhance the scientific excellence of research at MD Anderson through outstanding statistical designs and methods, including the proper and efficient use of standard and cutting-edge methods and the development of novel methods; and to train and mentor future biostatisticians through an innovative, relevant curriculum and through exposure to unique data sets, the latest research methodology and findings, and state-of-the-art computing technology. BRG faculty mentor postdoctoral fellows and participate in 3 formal doctoral degree programs, teaching courses and advising graduate researchers: (i) Quantitative Sciences at MD Anderson-UTHealth Graduate School of Biomedical Sciences; (ii) Interinstitutional Graduate Program in Biostatistics for Cancer Research, a joint effort with the Department of Statistics at Rice University; and (iii) a joint effort with Texas A&M University. Director Dr. J. Jack Lee and co-directors Dr. Yu Shen and Ms. Marcella Johnson lead the BRG, which contributes to rigor and reproducibility at the institution by holding weekly consensus reviews of all clinical and research protocols submitted for scientific review (except those with prior NIH approval and those submitted directly to the institutional review board [IRB]), collaborating in the design of all clinical trials initiated at MD Anderson, conducting the data analyses, and following operating procedures that facilitate reproducibility. The status of the BRG within an independent, quantitative science group ensures the objective assessment of research. A faculty member and statistical analyst team are assigned as the primary contacts for each research and clinical department within the institution, which fosters close collaboration and subject matter expertise within the assigned teams. Protocols and trials are evaluated before they are reviewed by the IRB to protect the scientific integrity of MD Anderson and the quality of patient care and laboratory animal use. All BRG faculty members and statistical analysts are available to collaborate or consult with clinical and laboratory-based researchers. The BRG provides added value through (i) Bayesian approaches to inference, adaptive randomization in clinical trials, and statistical and graphical modeling; (ii) Clinical Trial Conduct, a centralized collection of BRG-designed databases, web applications, and web services that support the conduct of clinical trials; and (iii) software programs to support clinical trial management, which are documented and distributed online to researchers around the world at no cost. During the past 6 years, the BRG supported 1,097 center members representing all CCSG programs and contributed to more than 1500 papers, 577 (38%) with IF >5 and 175 (11%) with IF >10. In grant Yr42, BRG utilization increased 20% compared with the previous 5-year average, and peer review-funded usage accounted for 77%. In Yr43, the institution contributed 44% ($3,337,751) of the total BRG operating expenses; other grant allocations covered 48% ($3,697,124), and CCSG funds provided 8% ($611,160). For Yr44, the BRG requests $629,456 (a 3% increase, but 7% of the total BRG operating expenses) from the CCSG.

项目摘要：生物统计资源小组(BRG) 生物统计资源小组(BRG)的使命是提高MD研究的科学水平 安德森通过出色的统计设计和方法，包括正确和有效地使用标准 和尖端方法和新方法的开发；以及培训和指导未来的生物统计学家 通过创新的相关课程和接触独特的数据集，最新研究 方法和发现，以及最先进的计算技术。BRG教师导师，博士后研究员 并参加3个正式的博士学位课程，教授课程并为研究生研究人员提供建议：(I) MD Anderson-UT Health生物医学研究生院的定量科学；(Ii)机构间 与莱斯大学统计系合作的癌症研究生物统计学研究生课程 以及(Iii)与德克萨斯农工大学的合作。导演李连杰博士及联席导演余承东博士 沈女士和马塞拉·约翰逊女士是BRG的负责人，BRG为该机构的严谨性和可重复性做出了贡献 通过每周对所有提交科学审查的临床和研究方案进行协商一致的审查(除 那些事先获得NIH批准的和那些直接提交给机构审查委员会的)，合作 在MD Anderson启动的所有临床试验的设计中，进行数据分析，并遵循操作 促进再现性的程序。BRG在一个独立的量化科学小组中的地位 确保研究工作的客观评价。一名教员和统计分析团队被分配为 机构内每个研究和临床部门的主要联系人，这有助于密切 指定团队内的协作和主题专业知识。在评估方案和试验之前 IRB对它们进行审查，以保护MD Anderson的科学完整性和患者护理的质量 用于实验动物。所有BRG教职员工和统计分析师都可以进行协作或咨询 与临床和实验室的研究人员合作。BRG通过(I)贝叶斯方法提供附加值 推论，临床试验中的自适应随机化，统计和图形建模；(Ii)临床试验 进行，这是BRG设计的数据库、Web应用程序和Web服务的集中化集合，支持 进行临床试验；及(Iii)支援临床试验管理的软件程序，包括 记录下来并在网上免费分发给世界各地的研究人员。在过去的6年里，BRG 支持代表CCSG所有项目的1097名中心成员，并撰写了1500多篇论文， 使用IF&>5的577个(38%)和使用IF&>10的175个(11%)。在拨款Yr42中，BRG利用率比 以前5年的平均水平，以及同行审查资助的使用率占77%。在43年，该机构 贡献了BRG运营费用总额的44%(3,337,751美元)；其他赠款拨款占48% (3,697,124美元)，CCSG基金提供了8%(611,160美元)。对于44日元，BRG要求629,456美元(增加3%， 但BRG总运营费用的7%)来自CCSG。