Automatic detection of vaping rate and patterning in the lab and the natural environment using Flexible, Robust Instrumentation of Electronic Nicotine Delivery Systems (FRIENDS)

使用灵活、稳健的电子尼古丁输送系统 (FRIENDS) 仪器自动检测实验室和自然环境中的吸烟率和模式

• 批准号: 10516860
• 负责人: LARRY W HAWK
• 金额: $ 64.17万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-12 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10516860
• 关键词: Address; Aerosols; Age; Behavior; Biochemical; Characteristics; Data; Data Reporting; Dependence; Detection; Development; Devices; Electromagnetics; Electronic Nicotine Delivery Systems; Electronic cigarette; Ensure; Environment; Frequencies; Future; Generations; Hour; Interruption; Laboratories; Libraries; Life; Location; Machine Learning; Manufacturer Name; Measures; Memory; Methods; Modeling; Monitor; Nature; Participant; Patient Self-Report; Pattern; Persons; Policies; Protocols documentation; Public Health; Research; Sampling; Signal Transduction; Subgroup; Surveys; System; Techniques; Testing; Time; Visit; Work; age group; base; combustible cigarette; design; experience; flexibility; human study; improved; inattention; indexing; instrument; instrumentation; nicotine exposure; novel; open source; recruit; sensor; vaping

PROJECT SUMMARY/ABSTRACT Electronic nicotine delivery systems (ENDS), particularly e-cigarettes, are increasingly prevalent, with their use matching or surpassing conventional cigarettes in certain age groups. Unlike combustible cigarettes, ENDS allow on-demand access to single puffs. Despite the central importance of accurate characterization of ENDS puff behavior in the natural environment, current assessment approaches are quite limited. To overcome critical barriers to progress in the field, we propose to evaluate and deploy an inexpensive instrument that can accurately, objectively, and non-obtrusively track real-time puff behavior across a wide variety of ENDS products without interrupting the natural behavior of the user. The Flexible Robust Instrumentation of ENDS (FRIENDS) monitor employs a miniature non-contact electromagnetic sensor that detects the current flow from the battery through the heater coil, allowing detection of puffs and puff duration regardless of ENDS generation and/or physical form (e.g., cig-alikes, pens, tanks, and pods systems). We propose recruiting 240 daily ENDS users, sampled for variety of ENDS devices and user characteristics. As new ENDS devices are encountered, they will be bench-tested to determine the best location for FRIENDS attachment, and we will measure the relationship between puff duration and volume. These results will be added to an open-source FRIENDS library. Each participant will vape ad lib with their FRIENDS-enabled ENDS during a video-taped lab visit and for 7 days in their natural environment. Biochemical measures of exposure and a range of self-report data will also be collected. The study will address several critical questions, including: To what extent does self-report reflect accurately capture variability (across people and days) in objective real-world vaping frequency, and how much does objective data from the lab visit improve prediction? To what extent do objective puff measures from FRIENDS outperform self-report measures in predicting nicotine exposure? Finally, what are the objective classes of ENDS use behavior (e.g., predominantly “bingers” [the focus of standard self-report] vs. predominantly “grazers” [a pattern missing from self-report but evident preliminary objective monitoring studies])? How common is each class? Is the ability of self-report to predict real-world vaping frequency and nicotine exposure particularly poor for grazers compared to bingers? The proposed study will provide novel and much-needed information about the nature of ENDS use behavior and has the potential to markedly influence future work. Moreover, the project will curate an extensive, open-source FRIENDS library, providing everything needed to produce and use the FRIENDS monitor with 125+ ENDS. Thus, we will make available to the field an inexpensive and accurate method for assessing puff quantity, duration, and patterning in a wide range of ENDS studies.

项目概要/摘要 电子尼古丁输送系统（ENDS），特别是电子烟，越来越普遍， 在某些年龄段，它们的使用量与传统香烟相当或超过。与可燃物不同 香烟、ENDS 允许按需获取单口香烟。尽管准确至关重要 自然环境中 ENDS 抽吸行为的表征，目前的评估方法是 相当有限。为了克服该领域取得进展的关键障碍，我们建议评估和部署 廉价的仪器，可以准确、客观、不引人注目地跟踪实时抽吸行为 跨各种 ENDS 产品，而不会中断用户的自然行为。灵活的 ENDS (FRIENDS) 监视器的鲁棒仪表采用微型非接触式电磁 传感器检测从电池流经加热器线圈的电流，从而检测抽吸的情况 和抽吸持续时间，无论 ENDS 的产生和/或物理形式如何（例如香烟类物品、笔、罐和 吊舱系统）。我们建议招募 240 名每日 ENDS 用户，针对各种 ENDS 设备进行抽样，并 用户特征。当遇到新的 ENDS 设备时，将对它们进行台架测试以确定 FRIENDS 依恋的最佳位置，我们将测量抽吸持续时间和 体积。这些结果将被添加到开源 FRIENDS 库中。每个参与者都会即兴抽电子烟 在实验室访问期间与他们启用 FRIENDS 的 ENDS 一起进行 7 天的自然观察 环境。还将收集暴露的生化测量值和一系列自我报告数据。这 研究将解决几个关键问题，包括：自我报告在多大程度上准确反映了 捕捉现实世界中客观的电子烟频率的变化（跨人和跨天），以及有多少变化 实验室访问的客观数据可以改善预测吗？客观的粉扑测量在多大程度上来自于 FRIENDS 在预测尼古丁暴露方面优于自我报告措施？最后，有哪些 ENDS 使用行为的目标类别（例如，主要是“bingers”[标准自我报告的重点] vs. 主要是“食草者”[自我报告中缺少这种模式，但初步目标很明显 监测研究]）？每个类别的常见程度如何？自我报告是否有能力预测现实世界的电子烟情况 与暴食者相比，食草者的频率和尼古丁暴露特别差？拟议的研究 将提供有关 ENDS 使用行为性质的新颖且急需的信息，并具有 对未来工作产生显着影响的潜力。此外，该项目将策划一个广泛的、开源的 FRIENDS 库，提供制作和使用 125+ 的 FRIENDS 监视器所需的一切 结束。因此，我们将为该领域提供一种廉价且准确的方法来评估粉扑 各种 ENDS 研究中的数量、持续时间和模式。