Automatic detection of vaping rate and patterning in the lab and the natural environment using Flexible, Robust Instrumentation of Electronic Nicotine Delivery Systems (FRIENDS)

使用灵活、稳健的电子尼古丁输送系统 (FRIENDS) 仪器自动检测实验室和自然环境中的吸烟率和模式

• 批准号: 10664004
• 负责人: LARRY W HAWK
• 金额: $ 58.72万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-12 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664004
• 关键词: Address; Aerosols; Behavior; Biochemical; Characteristics; Data; Data Reporting; Dependence; Detection; Development; Devices; Electromagnetics; Electronic Nicotine Delivery Systems; Electronic cigarette; Electronics; Ensure; Environment; Failure; Frequencies; Future; Generations; Hour; Interruption; Laboratories; Libraries; Life; Location; Machine Learning; Manufacturer; Measures; Memory; Methods; Modeling; Monitor; Nature; Participant; Patient Self-Report; Pattern; Persons; Policies; Protocols documentation; Public Health; Research; Sampling; Signal Transduction; Subgroup; Surveys; System; Techniques; Testing; Time; Video Recording; Videotape; Visit; Work; age group; behavior prediction; cigarette smoking; combustible cigarette; design; experience; flexibility; human study; improved; inattention; indexing; instrument; instrumentation; manufacture; nicotine exposure; novel; open source; recruit; sensor; vaping

PROJECT SUMMARY/ABSTRACT Electronic nicotine delivery systems (ENDS), particularly e-cigarettes, are increasingly prevalent, with their use matching or surpassing conventional cigarettes in certain age groups. Unlike combustible cigarettes, ENDS allow on-demand access to single puffs. Despite the central importance of accurate characterization of ENDS puff behavior in the natural environment, current assessment approaches are quite limited. To overcome critical barriers to progress in the field, we propose to evaluate and deploy an inexpensive instrument that can accurately, objectively, and non-obtrusively track real-time puff behavior across a wide variety of ENDS products without interrupting the natural behavior of the user. The Flexible Robust Instrumentation of ENDS (FRIENDS) monitor employs a miniature non-contact electromagnetic sensor that detects the current flow from the battery through the heater coil, allowing detection of puffs and puff duration regardless of ENDS generation and/or physical form (e.g., cig-alikes, pens, tanks, and pods systems). We propose recruiting 240 daily ENDS users, sampled for variety of ENDS devices and user characteristics. As new ENDS devices are encountered, they will be bench-tested to determine the best location for FRIENDS attachment, and we will measure the relationship between puff duration and volume. These results will be added to an open-source FRIENDS library. Each participant will vape ad lib with their FRIENDS-enabled ENDS during a video-taped lab visit and for 7 days in their natural environment. Biochemical measures of exposure and a range of self-report data will also be collected. The study will address several critical questions, including: To what extent does self-report reflect accurately capture variability (across people and days) in objective real-world vaping frequency, and how much does objective data from the lab visit improve prediction? To what extent do objective puff measures from FRIENDS outperform self-report measures in predicting nicotine exposure? Finally, what are the objective classes of ENDS use behavior (e.g., predominantly “bingers” [the focus of standard self-report] vs. predominantly “grazers” [a pattern missing from self-report but evident preliminary objective monitoring studies])? How common is each class? Is the ability of self-report to predict real-world vaping frequency and nicotine exposure particularly poor for grazers compared to bingers? The proposed study will provide novel and much-needed information about the nature of ENDS use behavior and has the potential to markedly influence future work. Moreover, the project will curate an extensive, open-source FRIENDS library, providing everything needed to produce and use the FRIENDS monitor with 125+ ENDS. Thus, we will make available to the field an inexpensive and accurate method for assessing puff quantity, duration, and patterning in a wide range of ENDS studies.

项目摘要/摘要 电子尼古丁输送系统，特别是电子烟越来越普遍， 它们的使用量在某些年龄段赶上或超过了传统香烟。与可燃物不同 香烟，烟头允许按需获得单次喷雾。尽管准确的 自然环境中端部膨胀行为的特征，目前的评估方法是 相当有限。为了克服在实地取得进展的关键障碍，我们建议评估和部署一个 一种廉价的仪器，可以准确、客观和非引人注目地跟踪实时喷雾行为 跨多种终端产品，而不会中断用户的自然行为。灵活的 健壮的末端仪器(Friends)监视器采用微型非接触式电磁 一种传感器，用于检测从电池流过加热器线圈的电流，从而检测到喷雾 以及与末端的生成和/或物理形式(例如，类似烟、笔、罐和 Pods系统)。我们建议招募240名日常终端用户，针对各种终端设备和 用户特征。当遇到新的终端设备时，将对它们进行台式测试，以确定 朋友联系的最佳位置，我们将测量泡芙持续时间和 音量。这些结果将被添加到开源朋友库中。每个参与者都将即兴发言 在视频实验室访问期间与他们的朋友一起完成，并在他们的自然环境中度过7天 环境。还将收集暴露的生化测量和一系列自我报告数据。这个 研究将解决几个关键问题，包括：自我报告在多大程度上准确地反映了 捕获客观真实世界蒸发频率的可变性(跨人和跨天)，以及 来自实验室访问的客观数据是否改善了预测？客观吹捧的措施在多大程度上 朋友在预测尼古丁暴露方面的表现优于自我报告的指标？最后，什么是 目的使用行为的客观类别(例如，主要是“bingers”[标准自我报告的重点] VS主要是“食草动物”[这是自我报告中缺失的模式，但初步目标很明显 监测研究])？每个班级有多普遍？是自我报告预测真实世界蒸发的能力 与暴饮者相比，食草者的频率和尼古丁暴露特别差吗？建议进行的研究 将提供有关终端使用行为性质的新颖且急需的信息，并具有 有可能显著影响未来的工作。此外，该项目将策划一个广泛的、开源的 Friends库，提供制作和使用125+的Friends显示器所需的一切 结束了。因此，我们将向现场提供一种廉价而准确的评估烟尘的方法 在广泛的END研究中的数量、持续时间和模式。