The neural underpinnings of disinhibited eating behavior in adolescents with and without obesity

项目摘要 博士夏皮罗是NIDDK指导研究科学家发展奖的优秀候选人。 目前，她正在从NIMH资助的T32项目的博士后研究职位过渡到 发展心理生物学，心理病理学和行为（MH 015442 - 39 A1）在部门的教师 科罗拉多大学精神病学教授她拥有流行病学和生物统计学公共卫生硕士学位， 流行病学博士学位，以及令人印象深刻的出版和资助记录。 拟议的研究计划有两个具体目标：1）确定能源过剩的程度 刺激改变神经元内的反应，以及稳态和非稳态之间的功能连接 有和没有肥胖的青少年的大脑区域; 2）确定神经元 内稳态和非内稳态脑区之间的连通性与饮食失调有关 肥胖和非肥胖青少年的行为。夏皮罗博士设计了一项创新研究， 这些目标将采用功能性神经影像学方法（目标1）和直接观察的测量， 饮食行为（Aim 2）她将测试一个总体假设，即改变大脑功能， 体内平衡和非体内平衡的大脑系统之间的差异是青少年饮食行为失控的基础， 这在肥胖的青少年中最为明显。 职业发展计划支持研究目标和夏皮罗博士向独立的过渡 在1）功能性神经成像方法和分析;和2）青年饮食行为：理论， 测量和解释。她的导师Jason Tregellas博士（小学）、Susan约翰逊、Marc科尼尔 （共同导师）分别是神经影像学、饮食行为和肥胖领域的公认专家。 博士夏皮罗还将接受额外的培训与领先的专家在该领域的儿科饮食行为， 宾夕法尼亚州立大学（合作者）。 科罗拉多大学丹佛分校安舒茨医学校区将提供丰富的培训和研究 为夏皮罗博士实现她的短期和长期研究和职业目标的环境。 具体来说，科罗拉多大学脑成像中心，其研究专用的3 T MRI扫描仪 （主任：Tregellas），将是夏皮罗博士目前和未来研究工作的重要资源。博士 夏皮罗还得到了她所在部门（精神病学）的全力支持，该部门将继续为她提供受保护的 研究时间，一个启动包与重要的研究资金，办公空间和设备。此外，博士。 夏皮罗将有机会进入儿童饮食实验室（主任：约翰逊），一个最先进的实验室 用于收集儿科群体饮食行为的观察数据。 该奖项将有助于建立基础，夏皮罗博士将建立她的专业知识作为一个领先的 研究儿童饮食行为和肥胖风险的神经基础的科学家。

PROJECT SUMMARY Dr. Shapiro is an excellent candidate for the NIDDK Mentored Research Scientist Development Award. Currently, she is transitioning from a postdoctoral research position in the NIMH-funded T32 program for Developmental Psychobiology, Psychopathology and Behavior (MH015442-39A1) to faculty in the Department of Psychiatry at the University of Colorado. She has a Master of Public Health in Epidemiology and Biostatistics, a Doctorate in Epidemiology, and an impressive publication and funding record. The proposed research plan has two specific aims: 1) Determine the extent to which an energy surplus stimulus alters neuronal response within, and functional connectivity between homeostatic and non-homeostatic brain regions in adolescents with and without obesity; and 2) Determine the degree to which neuronal connectivity between homeostatic and non-homeostatic brain regions is associated with disinhibited eating behaviors among adolescents with and without obesity. Dr. Shapiro has designed an innovative study to address these aims that will employ functional neuroimaging methodology (Aim 1) and a directly observed measure of disinhibited eating behavior (Aim 2). She will test the overarching hypothesis that altered brain function in and between homeostatic and non-homeostatic brain systems underlie disinhibited eating behaviors in adolescents, and that this is most pronounced in adolescents with obesity. The career development plan supports the research aims and Dr. Shapiro’s transition to independence with training in 1) Functional neuroimaging methodology and analysis; and 2) Eating behaviors in youth: theory, measurement and interpretation. Her mentors, Drs. Jason Tregellas (primary), Susan Johnson, Marc Cornier (co-mentor) are recognized experts in the fields of neuroimaging, eating behaviors, and obesity, respectively. Dr. Shapiro will also receive additional training with leading experts in the field of pediatric eating behaviors at the Pennsylvania State University (collaborators). The University of Colorado Denver, Anschutz Medical Campus will provide a rich training and research environment for Dr. Shapiro to accomplish her short- and long-term research and career goals. Specifically, the University of Colorado Brain Imaging Center, with its research-dedicated 3T MRI scanner (Director: Tregellas), will be a significant resource for Dr. Shapiro’s current and future research efforts. Dr. Shapiro also has the full backing of her department (Psychiatry) which will continue to provide her with protected research time, a start-up package with significant research funds, office space, and equipment. Furthermore, Dr. Shapiro will have access to The Children’s Eating Laboratory (Director: Johnson), a state-of-the-art laboratory for collecting observational data for eating behaviors in pediatric groups. This award will help to establish the foundation on which Dr. Shapiro will build her expertise as a leading scientist in the study of the neural underpinnings of pediatric eating behaviors and obesity risk.