The neural underpinnings of disinhibited eating behavior in adolescents with and without obesity

肥胖和非肥胖青少年去抑制饮食行为的神经基础

• 批准号: 10521245
• 负责人: Allison Livia Buti Shapiro
• 金额: $ 14.58万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10521245
• 关键词: Address; Adolescence; Adolescent; Adolescent obesity; Adult; Amygdaloid structure; Animals; Anterior; Appetite Regulation; Award; Behavior; Biometry; Brain; Brain imaging; Brain region; Characteristics; Child; Childhood; Colorado; Communication; Consumption; Cues; Data; Dedications; Desire for food; Development; Development Plans; Disinhibition; Down-Regulation; Eating; Eating Behavior; Emotional; Energy Intake; Energy consumption; Environment; Epidemiology; Equipment; Etiology; Faculty; Food; Foundations; Functional Magnetic Resonance Imaging; Funding; Glucose; Goals; Health; Hyperphagia; Hypothalamic structure; Individual; Inferior; Insula of Reil; Intervention; Laboratories; Link; Longevity; Magnetic Resonance Imaging; Master of Public Health; Measurement; Measures; Medical; Mentored Research Scientist Development Award; Mentors; Methodology; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Neurobiology; Neurons; Neuropeptide Receptor; Nucleus Accumbens; Obesity; Pennsylvania; Play; Population; Positioning Attribute; Postdoctoral Fellow; Prevalence; Process; Protocols documentation; Psychiatry; Psychopathology; Publications; Questionnaires; Research; Research Support; Resources; Rest; Rewards; Role; Satiation; Scientist; Signal Transduction; Stimulus; Sweetening Agents; System; Taste Perception; Testing; Time; Training; United States; Universities; Weight Gain; Youth; career; career development; cingulate cortex; design; developmental psychobiology; eating in absence of hunger; excessive weight gain; imaging facilities; improved; innovation; interest; neural; neuroimaging; novel; obesity development; obesity prevention; obesity risk; obesity treatment; overexpression; programs; response; theories

PROJECT SUMMARY Dr. Shapiro is an excellent candidate for the NIDDK Mentored Research Scientist Development Award. Currently, she is transitioning from a postdoctoral research position in the NIMH-funded T32 program for Developmental Psychobiology, Psychopathology and Behavior (MH015442-39A1) to faculty in the Department of Psychiatry at the University of Colorado. She has a Master of Public Health in Epidemiology and Biostatistics, a Doctorate in Epidemiology, and an impressive publication and funding record. The proposed research plan has two specific aims: 1) Determine the extent to which an energy surplus stimulus alters neuronal response within, and functional connectivity between homeostatic and non-homeostatic brain regions in adolescents with and without obesity; and 2) Determine the degree to which neuronal connectivity between homeostatic and non-homeostatic brain regions is associated with disinhibited eating behaviors among adolescents with and without obesity. Dr. Shapiro has designed an innovative study to address these aims that will employ functional neuroimaging methodology (Aim 1) and a directly observed measure of disinhibited eating behavior (Aim 2). She will test the overarching hypothesis that altered brain function in and between homeostatic and non-homeostatic brain systems underlie disinhibited eating behaviors in adolescents, and that this is most pronounced in adolescents with obesity. The career development plan supports the research aims and Dr. Shapiro’s transition to independence with training in 1) Functional neuroimaging methodology and analysis; and 2) Eating behaviors in youth: theory, measurement and interpretation. Her mentors, Drs. Jason Tregellas (primary), Susan Johnson, Marc Cornier (co-mentor) are recognized experts in the fields of neuroimaging, eating behaviors, and obesity, respectively. Dr. Shapiro will also receive additional training with leading experts in the field of pediatric eating behaviors at the Pennsylvania State University (collaborators). The University of Colorado Denver, Anschutz Medical Campus will provide a rich training and research environment for Dr. Shapiro to accomplish her short- and long-term research and career goals. Specifically, the University of Colorado Brain Imaging Center, with its research-dedicated 3T MRI scanner (Director: Tregellas), will be a significant resource for Dr. Shapiro’s current and future research efforts. Dr. Shapiro also has the full backing of her department (Psychiatry) which will continue to provide her with protected research time, a start-up package with significant research funds, office space, and equipment. Furthermore, Dr. Shapiro will have access to The Children’s Eating Laboratory (Director: Johnson), a state-of-the-art laboratory for collecting observational data for eating behaviors in pediatric groups. This award will help to establish the foundation on which Dr. Shapiro will build her expertise as a leading scientist in the study of the neural underpinnings of pediatric eating behaviors and obesity risk.

项目概要 Shapiro 博士是 NIDDK 指导研究科学家发展奖的优秀候选人。 目前，她正在从 NIMH 资助的 T32 项目的博士后研究职位过渡到 发展心理生物学、精神病理学和行为学（MH015442-39A1）给系里的教员 科罗拉多大学精神病学博士。她拥有流行病学和生物统计学公共卫生硕士学位， 流行病学博士学位，以及令人印象深刻的出版物和资助记录。 拟议的研究计划有两个具体目标：1）确定能源剩余的程度 刺激改变体内的神经元反应以及稳态和非稳态之间的功能连接 患有和不患有肥胖症的青少年的大脑区域； 2）确定神经元的程度 稳态和非稳态大脑区域之间的连接与去抑制饮食有关 肥胖和非肥胖青少年的行为。夏皮罗博士设计了一项创新研究来解决 这些目标将采用功能性神经影像方法（目标 1）和直接观察的测量 解除抑制的饮食行为（目标 2）。她将测试改变大脑功能的总体假设 稳态和非稳态大脑系统之间的差异是青少年饮食行为失控的基础， 这在肥胖青少年中最为明显。 职业发展计划支持夏皮罗博士的研究目标和向独立的过渡 接受过 1) 功能神经影像方法和分析方面的培训； 2) 青少年的饮食行为：理论， 测量和解释。她的导师，博士。 Jason Tregellas（小学）、Susan Johnson、Marc Cornier （共同导师）分别是神经影像学、饮食行为和肥胖领域的公认专家。 夏皮罗博士还将接受儿科饮食行为领域领先专家的额外培训 宾夕法尼亚州立大学（合作者）。 科罗拉多大学丹佛分校 Anschutz 医学校区将提供丰富的培训和研究 为夏皮罗博士实现她的短期和长期研究和职业目标提供环境。 具体来说，科罗拉多大学脑成像中心及其研究专用 3T MRI 扫描仪 （主任：Tregellas）将成为夏皮罗博士当前和未来研究工作的重要资源。博士。 夏皮罗还得到了她的部门（精神病学）的全力支持，该部门将继续为她提供受保护的治疗 研究时间、包含大量研究资金、办公空间和设备的启动方案。此外，博士。 夏皮罗将可以使用最先进的儿童饮食实验室（主任：约翰逊） 用于收集儿科群体饮食行为的观察数据。 该奖项将有助于奠定夏皮罗博士作为领先者的专业知识的基础 研究儿童饮食行为和肥胖风险的神经基础的科学家。