The neural underpinnings of disinhibited eating behavior in adolescents with and without obesity

肥胖和非肥胖青少年去抑制饮食行为的神经基础

• 批准号: 10084293
• 负责人: Allison Livia Buti Shapiro
• 金额: $ 14.58万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10084293
• 关键词: Address; Adolescence; Adolescent; Adolescent obesity; Adult; Amygdaloid structure; Animals; Anterior; Award; Back; Behavior; Biometry; Brain; Brain imaging; Brain region; Characteristics; Child; Childhood; Colorado; Communication; Consumption; Cues; Data; Desire for food; Development; Development Plans; Down-Regulation; Eating; Eating Behavior; Emotional; Energy Intake; Environment; Epidemiology; Equipment; Etiology; Faculty; Food; Foundations; Functional Magnetic Resonance Imaging; Funding; Glucose; Goals; Health; Hyperphagia; Hypothalamic structure; Individual; Inferior; Insula of Reil; Intervention; Laboratories; Link; Longevity; Magnetic Resonance Imaging; Master of Public Health; Measurement; Measures; Medical; Mentored Research Scientist Development Award; Mentors; Methodology; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Neurobiology; Neurons; Neuropeptide Receptor; Nucleus Accumbens; Obesity; Palate; Pennsylvania; Play; Population; Positioning Attribute; Prevalence; Process; Protocols documentation; Psychiatry; Psychopathology; Publications; Questionnaires; Research; Research Support; Resources; Rest; Rewards; Role; Satiation; Scientist; Signal Transduction; Stimulus; Sweetening Agents; System; Taste Perception; Testing; Time; Training; United States; Universities; Weight Gain; Youth; career; career development; cingulate cortex; design; developmental psychobiology; eating in absence of hunger; excessive weight gain; improved; innovation; interest; neuroimaging; novel; obesity development; obesity prevention; obesity risk; obesity treatment; overexpression; programs; relating to nervous system; response; theories

PROJECT SUMMARY Dr. Shapiro is an excellent candidate for the NIDDK Mentored Research Scientist Development Award. Currently, she is transitioning from a postdoctoral research position in the NIMH-funded T32 program for Developmental Psychobiology, Psychopathology and Behavior (MH015442-39A1) to faculty in the Department of Psychiatry at the University of Colorado. She has a Master of Public Health in Epidemiology and Biostatistics, a Doctorate in Epidemiology, and an impressive publication and funding record. The proposed research plan has two specific aims: 1) Determine the extent to which an energy surplus stimulus alters neuronal response within, and functional connectivity between homeostatic and non-homeostatic brain regions in adolescents with and without obesity; and 2) Determine the degree to which neuronal connectivity between homeostatic and non-homeostatic brain regions is associated with disinhibited eating behaviors among adolescents with and without obesity. Dr. Shapiro has designed an innovative study to address these aims that will employ functional neuroimaging methodology (Aim 1) and a directly observed measure of disinhibited eating behavior (Aim 2). She will test the overarching hypothesis that altered brain function in and between homeostatic and non-homeostatic brain systems underlie disinhibited eating behaviors in adolescents, and that this is most pronounced in adolescents with obesity. The career development plan supports the research aims and Dr. Shapiro’s transition to independence with training in 1) Functional neuroimaging methodology and analysis; and 2) Eating behaviors in youth: theory, measurement and interpretation. Her mentors, Drs. Jason Tregellas (primary), Susan Johnson, Marc Cornier (co-mentor) are recognized experts in the fields of neuroimaging, eating behaviors, and obesity, respectively. Dr. Shapiro will also receive additional training with leading experts in the field of pediatric eating behaviors at the Pennsylvania State University (collaborators). The University of Colorado Denver, Anschutz Medical Campus will provide a rich training and research environment for Dr. Shapiro to accomplish her short- and long-term research and career goals. Specifically, the University of Colorado Brain Imaging Center, with its research-dedicated 3T MRI scanner (Director: Tregellas), will be a significant resource for Dr. Shapiro’s current and future research efforts. Dr. Shapiro also has the full backing of her department (Psychiatry) which will continue to provide her with protected research time, a start-up package with significant research funds, office space, and equipment. Furthermore, Dr. Shapiro will have access to The Children’s Eating Laboratory (Director: Johnson), a state-of-the-art laboratory for collecting observational data for eating behaviors in pediatric groups. This award will help to establish the foundation on which Dr. Shapiro will build her expertise as a leading scientist in the study of the neural underpinnings of pediatric eating behaviors and obesity risk.

项目摘要 Shapiro博士是NIDDK指导研究科学家发展奖的出色候选人。 目前，她正在从NIMH资助的T32计划中的博士后研究职位过渡 发育心理生物学，心理病理学和行为（MH015442-39A1） 科罗拉多大学精神病学。她拥有流行病学和生物统计学公共卫生硕士， 流行病学博士学位，以及令人印象深刻的出版物和资金记录。 拟议的研究计划有两个具体的目的：1）确定能量盈余的程度 刺激改变了内部的神经元反应，并在稳态和非间境内的功能连通性 有或没有肥胖的青少年的大脑区域； 2）确定神经元的程度 体内平衡和非整体大脑区域之间的连通性与抑制饮食有关 有或没有肥胖的青少年的行为。 Shapiro博士设计了一项创新的研究来解决 这些目标将采用功能性神经影像学方法（AIM 1）以及直接观察到的测量 抑制饮食行为（AIM 2）。她将检验总体假设，该假设改变了大脑功能和 在稳态和非智力脑系统之间 而且这在肥胖的青少年中最为明显。 职业发展计划支持该研究的目的以及夏皮罗博士向独立的过渡 在1）功能性神经影像学方法和分析中进行培训； 2）青年中的饮食行为：理论， 测量和解释。她的导师博士。杰森·特雷格拉斯（Jason Tregellas）（主要），苏珊·约翰逊（Susan Johnson），马克·康尼尔（Marc Cornier） （联盟）分别是神经影像，饮食行为和肥胖领域的公认专家。 Shapiro博士还将在儿科饮食行为领域的领先专家接受其他培训 宾夕法尼亚州立大学（合作者）。 科罗拉多大学丹佛分校，安苏兹医学校园将提供丰富的培训和研究 Shapiro博士实现她短期和长期研究和职业目标的环境。 具体而言，科罗拉多大学脑成像中心，其研究青少年3T MRI扫描仪 （董事：特雷格拉斯）将成为夏皮罗博士当前和未来研究工作的重要资源。博士 夏皮罗还拥有她的部门（精神病学）的全部支持，该部门将继续为她提供受保护的 研究时间，具有大量研究基金，办公空间和设备的启动包。此外，博士 Shapiro将可以进入儿童饮食实验室（董事：Johnson），这是最先进的实验室 用于收集小儿饮食行为的观察数据。 该奖项将有助于建立夏皮罗博士将成为领先的专业知识的基础 科学家在研究小儿饮食行为和肥胖风险的神经基础中。