Reinvigorating HIV Prevention and Care for People Who Use Drugs: Accelerating Progress and Sustaining Gains in the Midst of Societal Disruption

项目概要/摘要-跨学科研究方法核心 跨学科研究方法（TRM）核心的总体目标是（1）培训和支持我们的 相关研究方法的应用，包括可能是新的方法， 复杂，（2）使我们的调查人员意识到创新，尖端的方法，可能是有用的，在他们的工作 并可以开辟激发新的研究问题的可能性，（3）有助于方法论 预付款。重点的一个主要领域将是了解多层次影响所需的方法， 在艾滋病毒预防和护理工作中，开展时变进程和大事件/大趋势（BE/BT）。到 支持多学科研究人员的工作，我们代表了一系列的专业知识，包括领域 研究和抽样;人种学;传染病病因学、流行病学和监测;社区- 参与研究;干预设计和测试，包括优化;以及（现在） 因果推理，以及实施科学的框架和方法。需要这种专门知识， 了解BE/BT如何影响PWUD的生活和健康，并开展研究， 干预措施将是相关的，有弹性的，并能适应社会变化。基于以往的成功， 核心将继续专注于协助附属研究者整合研究设计和方法， 预防和护理理论;创建因果途径的可测试模型;检测和应对艾滋病毒 以及制定、测试和实施有效和可持续的社会， 行为和社会结构干预。TRM核心的具体目标是：目标1。领导该领域， 支持CDUHR附属调查人员应用方法，以加强在以下背景下进行的研究： 通过提供有关定量、定性和定量的培训、研讨会和咨询， 混合方法，包括创造性的应用和现有方法的新扩展。目标二。引领 多阶段优化战略（MOST），实施科学（IS）， 以社区为基础的参与性研究方法，并建立CDUHR调查人员的能力， 开发高效，高效，可实施和可持续的行为，生物行为和社会- * 通过提供培训和支持，对艾滋病毒感染者进行预防和治疗的结构性干预， 这方面目标3。向更大的领域传播新的研究方法，特别是与以下方面有关的方法： 应对可能破坏或促进艾滋病毒有效预防和护理的社会变化， PWUD。

Project Summary/Abstract – Transdisciplinary Research Methods Core The overarching goals of the Transdisciplinary Research Methods (TRM) Core are to (1) train and support our affiliated investigators in application of relevant research methods, including methods that may be new or complex, (2) make our investigators aware of innovative, cutting-edge methods that may be useful in their work and can open up possibilities that inspire new research questions, and (3) contribute to methodological advances. One primary area of emphasis will be on methods needed to understand the impacts of multilevel, time-varying processes and Big Events/BigTrends (BE/BT) on HIV prevention and care among PWUD. To support the work of a multidisciplinary set of investigators, we represent a range of expertise that includes field research and sampling; ethnography; infectious disease etiology, epidemiology and surveillance; community- engaged research; intervention design and testing, including optimization; and (now) designs and methods for causal inference, and the frameworks and methods of implementation science. This expertise is needed to understand how BE/BT impact the lives and health of PWUD, and to carry out research to develop interventions that will be relevant, resilient, and adaptable to societal changes. Building on prior successes, this Core will continue to focus on assisting affiliated investigators to integrate study design and methods with theories of prevention and care; create testable models of causal pathways; detect and respond to HIV outbreaks and other sequelae of BE/BT; and develop, test and implement potent and sustainable social, behavioral, and social-structural interventions. Specific Aims of the TRM core are: Aim 1. Lead the field and support CDUHR affiliated investigators in applying methods to enhance research conducted in the context of disruptions due to BE/BT by providing training, seminars, and consultation on quantitative, qualitative, and mixed methods, including the creative application and novel extensions of existing methods. Aim 2. Lead the field in the integration of the multiphase optimization strategy (MOST), implementation science (IS), and community-based participatory research (CBPR) methods, and build the capacity of CDUHR investigators to develop highly effective, efficient, implementable, and sustainable behavioral, biobehavioral, and social- structural interventions for prevention and treatment of HIV among PWUD by providing training and support in this area. Aim 3. Disseminate new research methods to the larger field, particularly methods relevant to responding to societal changes which may undermine or facilitate effective HIV prevention and care among PWUD.