Data Analysis Core

项目摘要，数据分析核心 数据分析核心提供端到端的实验和计算专业知识：初始实验 设计和电源研究、持续数据生成和分析，以及最终数据存储和共享。这个 数据分析核心将支持器官特定项目的高维数据生成和分析， 包括不同生物尺度上的多组学数据集成方法。该核心将与以下公司密切合作 HuBMAP母公司协调数据和管道，以实现跨组织的荟萃分析。核心领导者将 参加每月中心执行委员会与器官特定项目负责人的会议，并 联盟会议，以确保为新研究提供充足的实验支持和计算资源 与HuBMAP的方向和合作。核心将有一名指定的项目经理和数据经理 为协助数据标准和协调、数据验证、数据争论和总体数据存储， 数据和软件共享，以及与蜂巢共享基因组数据。总而言之，数据分析核心将 通过提供健壮、可重现的实验方案和 计算方法来表征皮肤位置、性别、种族和衰老对细胞和 皮肤的分子变化；分析空间和时间数据以推断细胞之间的相互作用和串扰 类型；并将我们的三维多组学皮肤数据集图谱与蜂巢整合，以促进交叉 HuBMAP联合体的组织分析。

Project Summary, Data Analysis Core The Data Analysis Core provides end-to-end experimental and computational expertise: initial experimental design and power studies, ongoing data generation and analysis, and ultimate data deposition and sharing. The Data Analysis Core will support high-dimensional data generation and analysis for the Organ Specific Project, including multi-omics data integration methods at distinct biological scales. This Core will collaborate closely with the HuBMAP HIVE to harmonize data and pipelines to enable meta-analyses across tissues. Core Leaders will participate in the monthly Center Executive Committee meetings with the Organ Specific Project Lead and Consortium meetings to ensure ample experimental support and computational resources for new research directions and collaborations with HuBMAP. The Core will have a designated Project Manager and Data Manager to assist with data standards and harmonization, data validation, data wrangling, and overall data deposition, data and software sharing, and genomic data sharing with the HIVE. In summary, the Data Analysis Core will support the overall research objectives by providing robust, reproducible experimental protocols and computational methods to characterize the impact of skin location, sex, race, and aging on the cellular and molecular changes to skin; to analyze spatial and temporal data to infer interactions and crosstalk between cell types; and to integrate our atlas of three-dimensional multi-omics skin datasets with the HIVE to promote cross- tissue analyses in the HuBMAP Consortium.