Purchase of MVE Fusion Self-Sustaining Cryogenic Freezers

购买 MVE Fusion 自持式低温冷冻机

• 批准号: 10533525
• 负责人: Luis J Montaner
• 金额: $ 11.05万
• 依托单位: WISTAR INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2023-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533525
• 关键词: Address; Area; Basic Science; Biomedical Research; COVID-19 vaccine; Cancer Biology; Communicable Diseases; Complement; Core Facility; Electricity; Equipment; Faculty; Farm; Foxes; Freezing; Funding; Goals; Growth; Immunology; Immunotherapy; Institutes; Intellectual Property; Legal patent; Liquid substance; Location; Malignant Neoplasms; Monoclonal Antibody Therapy; Nitrogen; Phase; Recording of previous events; Research; Research Institute; Research Personnel; Resource Sharing; Resources; Running; Sampling; Technology; Temperature; The Wistar Institute; Time; Translational Research; United States; United States National Institutes of Health; Vaccines; cryogenics; evaporation; innovation; member; operation; research clinical testing; success; vapor

Project Summary The goal of this request is to install two innovative Chart MVE Fusion 1500 self-sustaining Cryogenic freezers for -150oC to -190oC temperature long-term storage by creating a shared new cryofreezer farm which will expand the Institute’s cryostorage capabilities. The new cryofeezer farm will support 35 active research labs and core facilities as well as storage of research samples with intellectual property value. As additional freezers cannot be added to the current farm facility due to space constrains and renovations cannot be attempted to expand the footprint of the existing farm, creation of a new cryofreezer farm is critical for Wistar researchers to expand their current usage to support 92 NIH-funded projects and pursue new directions of research and discovery. Two cutting-edge, stand-alone, self-sustaining cryofreezers will enable creation of a new, added cryofreezer farm within the tower basement of the Institute (room B02) and without a need for pipelines providing exogenous replacement of liquid nitrogen. Notably, Chart MVE Fusion self-sustaining freezers utilize innovative Qdrive cryocooling technology to operate on only 50 liters of liquid nitrogen and run solely on electricity after initial liquid nitrogen fill, thus not requiring added replacement of liquid nitrogen. The Chart MVE Fusion 1500 cryogenic Freezer is the world’s first cryofreezer to use patented Qdrive Cryo-cooler technology to remove heat from and reuse existing supplied liquid nitrogen to maintain freezer temperature. By contrast, traditional vapor phase cryofreezers require 80 liters of liquid nitrogen for initial fill and then subsequent daily routine filling to compensate for liquid nitrogen loss due to usage and evaporation. The requested MVE Fusion 1500 cryofreezers will address two scientific needs at the same time: (a) the expansion of cryostorage capabilities with 72 additional storage racks to keep pace with Institute growth, and (b) establish cyofreezer units in a new location without the need to provide constant liquid nitrogen supply as the Institute transitions towards self-sustaining green technology. We will address these needs by implementing a specific aim to install two Chart MVE Fusion 1500 self-sustaining cryofreezers and create a shared satellite cryofreezer farm at The Wistar Institute. The new MVE Fusion cryofreezers will be managed by Wistar’s Department of Operations and overseen by Dr. Luis Montaner, Vice President of Scientific Operations and Associate Director for Shared Resources, on behalf of the faculty at the Wistar Institute. The Wistar Institute is the nation’s oldest independent biomedical research institute, with an energized and highly collaborative faculty who perform cutting-edge research on cancer biology, immunology and vaccines. The Institute boasts a long history of research success in monoclonal antibody therapy and cancer biology (Stelara®) and vaccines (RotaTeq©), including the second COVID-19 vaccine to move into clinical testing in the United States.

项目概要 此请求的目标是安装两台创新的 Chart MVE Fusion 1500 自持式低温冷冻机 通过创建一个共享的新冷冻机农场（该农场将扩大），实现 -150oC 至 -190oC 温度的长期储存 该研究所的低温储存能力。新的 Cryofeezer 农场将支持 35 个活跃的研究实验室和核心 设施以及具有知识产权价值的研究样本的储存。由于额外的冰柜无法 由于空间限制和翻新无法尝试扩大现有农场设施 现有农场的占地面积，创建一个新的冷冻农场对于 Wistar 研究人员扩大其研究范围至关重要 目前的用途是支持 92 个 NIH 资助的项目并追求新的研究和发现方向。二 尖端、独立、自我维持的冷冻机将能够创建一个新的、附加的冷冻机场 研究所塔楼地下室（B02室）内，无需管道提供外源 更换液氮。值得注意的是，Chart MVE Fusion 自持式冰箱采用创新的 Qdrive 低温冷却技术仅需 50 升液氮即可运行，初始液氮后仅靠电力运行 充氮，因此不需要额外更换液氮。 Chart MVE Fusion 1500 低温 Freezer 是世界上第一台采用 Qdrive 冷冻冷却器专利技术来去除热量和 重复利用现有供应的液氮来维持冷冻室温度。相比之下，传统的气相 冷冻柜需要 80 升液氮进行初始填充，然后进行日常填充以进行补偿 由于使用和蒸发造成的液氮损失。所要求的 MVE Fusion 1500 冷冻机将解决 同时满足两个科学需求：(a) 扩大低温储存能力，增加 72 个储存空间 机架以跟上研究所的发展步伐，并且 (b) 在新地点建立冷冻柜，而无需 随着研究所向自我维持的绿色技术过渡，提供持续的液氮供应。我们 将通过安装两台 Chart MVE Fusion 1500 自我维持的具体目标来满足这些需求 冷冻机，并在 Wistar 研究所创建共享卫星冷冻机农场。全新 MVE 融合 冷冻机将由 Wistar 运营部管理，并由副总裁 Luis Montaner 博士监督 科学运营总裁兼共享资源副主任，代表学院的教员 威斯塔研究所。威斯塔研究所是美国历史最悠久的独立生物医学研究所，拥有 充满活力、高度协作的教师队伍，在癌症生物学、免疫学方面进行前沿研究 和疫苗。该研究所在单克隆抗体治疗和癌症方面拥有悠久的研究成功历史 生物学 (Stelara®) 和疫苗 (RotaTeq©)，包括第二种进入临床的 COVID-19 疫苗 在美国进行测试。