Purchase of MVE Fusion Self-Sustaining Cryogenic Freezers

购买 MVE Fusion 自持式低温冷冻机

• 批准号: 10533525
• 负责人: Luis J Montaner
• 金额: $ 11.05万
• 依托单位: WISTAR INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2023-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533525
• 关键词: Address; Area; Basic Science; Biomedical Research; COVID-19 vaccine; Cancer Biology; Communicable Diseases; Complement; Core Facility; Electricity; Equipment; Faculty; Farm; Foxes; Freezing; Funding; Goals; Growth; Immunology; Immunotherapy; Institutes; Intellectual Property; Legal patent; Liquid substance; Location; Malignant Neoplasms; Monoclonal Antibody Therapy; Nitrogen; Phase; Recording of previous events; Research; Research Institute; Research Personnel; Resource Sharing; Resources; Running; Sampling; Technology; Temperature; The Wistar Institute; Time; Translational Research; United States; United States National Institutes of Health; Vaccines; cryogenics; evaporation; innovation; member; operation; research clinical testing; success; vapor

Project Summary The goal of this request is to install two innovative Chart MVE Fusion 1500 self-sustaining Cryogenic freezers for -150oC to -190oC temperature long-term storage by creating a shared new cryofreezer farm which will expand the Institute’s cryostorage capabilities. The new cryofeezer farm will support 35 active research labs and core facilities as well as storage of research samples with intellectual property value. As additional freezers cannot be added to the current farm facility due to space constrains and renovations cannot be attempted to expand the footprint of the existing farm, creation of a new cryofreezer farm is critical for Wistar researchers to expand their current usage to support 92 NIH-funded projects and pursue new directions of research and discovery. Two cutting-edge, stand-alone, self-sustaining cryofreezers will enable creation of a new, added cryofreezer farm within the tower basement of the Institute (room B02) and without a need for pipelines providing exogenous replacement of liquid nitrogen. Notably, Chart MVE Fusion self-sustaining freezers utilize innovative Qdrive cryocooling technology to operate on only 50 liters of liquid nitrogen and run solely on electricity after initial liquid nitrogen fill, thus not requiring added replacement of liquid nitrogen. The Chart MVE Fusion 1500 cryogenic Freezer is the world’s first cryofreezer to use patented Qdrive Cryo-cooler technology to remove heat from and reuse existing supplied liquid nitrogen to maintain freezer temperature. By contrast, traditional vapor phase cryofreezers require 80 liters of liquid nitrogen for initial fill and then subsequent daily routine filling to compensate for liquid nitrogen loss due to usage and evaporation. The requested MVE Fusion 1500 cryofreezers will address two scientific needs at the same time: (a) the expansion of cryostorage capabilities with 72 additional storage racks to keep pace with Institute growth, and (b) establish cyofreezer units in a new location without the need to provide constant liquid nitrogen supply as the Institute transitions towards self-sustaining green technology. We will address these needs by implementing a specific aim to install two Chart MVE Fusion 1500 self-sustaining cryofreezers and create a shared satellite cryofreezer farm at The Wistar Institute. The new MVE Fusion cryofreezers will be managed by Wistar’s Department of Operations and overseen by Dr. Luis Montaner, Vice President of Scientific Operations and Associate Director for Shared Resources, on behalf of the faculty at the Wistar Institute. The Wistar Institute is the nation’s oldest independent biomedical research institute, with an energized and highly collaborative faculty who perform cutting-edge research on cancer biology, immunology and vaccines. The Institute boasts a long history of research success in monoclonal antibody therapy and cancer biology (Stelara®) and vaccines (RotaTeq©), including the second COVID-19 vaccine to move into clinical testing in the United States.

项目摘要 该请求的目的是安装两个创新的图表MVE Fusion 1500自我维持的低温冰柜 对于-150OC至-190oC温度长期存储，通过创建共享的新冰冻冰柜农场，该农场将扩展 该研究所的低温剂功能。新的Cryofeezer农场将支持35个活跃的研究实验室和核心 设施以及具有知识产权的研究样本的存储。因为其他冰柜不能 由于空间的限制和改革而无法尝试扩展，因此可以添加到当前的农场工厂 现有农场的占地面积，创建一个新的Cryofreezer农场对于Wistar研究人员扩大其扩展至关重要 目前的用法支持92个NIH资助的项目并购买新的研究和发现方向。二 尖端的，独立的，自我维持的冷冻冰冻机可以创建一个新的，添加的Cryofreezer农场 在研究所的塔楼地下室（B02室）内，无需提供外源的管道 替代液氮。值得注意的是，Chart Mve Fusion自我维持的冰柜利用创新的QDRIVE 冷冻技术仅在50升液氮上运行，并仅在初始液体后运行电力 氮填充，因此不需要添加液体氮的替代。图表MVE Fusion 1500低温 Freezer是世界上第一个使用专利的QDRIVE冷冻冷却器技术去除热量和 重用现有的液氮以保持冷冻温度。相比之下，传统蒸气阶段 冷冻冻箱需要80升液氮才能初始填充，然后随后的日常填充以补偿 用于由于使用和蒸发而导致的液氮损失。请求的MVE Fusion 1500 Cryofreefers将解决 同时两个科学需求：（a）额外存储72个冷冻仪功能的扩展 与研究所的增长保持同步的架子，（b）在新位置建立Cyofreezer单元，而无需 随着研究所向自我维持的绿色技术过渡，提供恒定的液氮供应。我们 将通过实施特定的目标来安装两个图表MVE Fusion 1500自我维持，以满足这些需求 Cryofrefreezers并在Wistar Institute创建一个共享的卫星Cryofrefreezer农场。新的MVE Fusion Cryofreefers将由Wistar的运营部管理，并由Luis Montaner博士监督 科学运营总裁兼共享资源副主任，代表教师 Wistar Institute。维斯塔尔研究所（Wistar Institute）是美国最古老的独立生物医学研究所， 对癌症生物学，免疫学进行尖端研究，充满活力和高度协作的教师 和疫苗。该研究所在单克隆抗体治疗和癌症方面拥有悠久的研究成功史 生物学（Stelara®）和疫苗（RotateQ©），包括第二种Covid-19疫苗进入临床 在美国进行测试。