Tri-Society Meeting of International Cytokine Society (ICS), International Societ

描述（由申请人提供）：在过去几年中，人们越来越认识到白细胞、细胞因子、干扰素与癌症和感染性疾病的病理生理学相互作用的复杂性和特异性。对疾病机制和治疗新概念的更好理解将从汇集多学科论坛中产生，在这些论坛中，新的和成熟的科学家可以展示和讨论最新的进展。该提案寻求支持初级研究人员参加2009年在里斯本举行的三个主要学会（白细胞生物学学会、国际细胞因子学会和国际干扰素和细胞因子研究学会）联合年会，讨论健康和疾病中的免疫宿主调节问题，题为“健康和疾病中的细胞和细胞因子相互作用”。所有三个学会的年度会议都有一个长期的传统，即突出最高质量和最具创新性的工作，这些工作涉及疾病发病机制（癌症，感染性，自身免疫性）和宿主防御中的细胞因子，干扰素相关和白细胞功能的机制。2009年的三社会议将发扬这一传统，将三社所有成员聚集在一个屋檐下，最大限度地开展互动，使所有与会者受益。会议的具体目标概述如下。 具体目标1：为来自学术、政府和工业实验室和医院的800-1000名参与者提供一个论坛，分享白细胞-细胞因子/干扰素相互作用、病理生理学和宿主防御的最新进展。演讲将包括特邀演讲者的演讲以及从提交的摘要中选择的演讲和海报展示。 具体目标2： 提出一个计划，在以下领域捕捉到上一年最重要的进步：健康和疾病中细胞因子基因表达的microRNA调节，细胞因子和炎症反应的表观遗传调节，干扰素的作用，模式识别受体，新的T辅助细胞亚群，神经生物学，健康和疾病中的巨噬细胞，T细胞和疫苗，病毒感染和炎症，先天免疫的控制，细胞因子与癌症，细胞因子与干扰素信号转导的最新进展。炎症体激活和IL-1和肥大细胞的作用，IFN刺激基因，病原体的先天识别，病原体与Toll样受体的相互作用：TB和疟疾，病原体对细胞因子反应的操纵细胞因子和病毒发病机制，真菌感染和宿主反应的传感，慢性炎症性疾病和免疫治疗。 具体目标3：为年轻的研究人员和受训人员提供机会，与各自领域的知名研究人员密切互动，并以海报或口头报告的形式介绍他们的研究。 具体目标4：为妇女、代表性不足的少数群体和残疾人提供机会，让他们参加一次会议，展示他们的工作，并促进与各自领域的其他科学家的互动。

DESCRIPTION (provided by applicant): Over the past several years there has been a growing appreciation for the complexity and specificity of the interactions of leukocytes, cytokines, interferons and pathophysiology of cancer and infectious disease. Greater understanding of mechanisms of disease and novel concepts for therapy will emerge from bringing together multi-disciplinary forums where the most advances can be presented and discussed by new and established scientists. This proposal seeks support for junior investigator attendance to the 2009 joint annual meetings of three leading Societies addressing immune host modulation in health and disease (Society for Leukocyte Biology, International Cytokine Society, and the International Society of Interferon and Cytokine Research) entitled, "Cellular and Cytokine Interactions in Health and Disease" to be held in Lisbon. Annual meetings by all three Societies have a long-standing tradition of highlighting the highest quality and most innovative work on the mechanisms underlying cytokine, interferon-related, and leukocyte function in disease pathogenesis (cancer, infectious, autoimmune) and host defense. The 2009 Tri-Society meeting will build in this tradition by bringing together under one roof all members of the three Societies to maximize interaction and benefit for all participants. The Specific Aims of the conference are outlined below. Specific Aim 1: To provide a forum for 800-1000 participants from academic, governmental and industrial laboratories and hospitals to share recent advances in leukocyte-cytokine/interferon interactions, pathophysiology and host defense. Presentations will include talks by invited speakers as well as talks and poster presentations chosen from submitted abstracts. Specific Aim 2.: To present a program that captures the most significant advances from the previous year in the following areas: MicroRNA Regulation of Cytokine Gene Expression in Health and Disease, Epigenetic Regulation of Cytokine and Inflammatory Responses, Role of Interferons, Pattern Recognition Receptors, New T-helper Subsets, Neutrophil Biology, The Macrophages in Health and Disease, T-regs and Vaccines, Viral Infections & Inflammation, Control of Innate Immunity, Cytokines and Cancer, Recent Advances in Cytokine and IFN signaling. Inflammasome activation and the role of IL-1 and Mast Cells, IFN-stimulated genes, Innate Recognition of Pathogens, Pathogen interactions with Toll-like receptors: TB and Malaria, Pathogen Manipulation of Cytokine Responses Cytokines and viral pathogenesis, Sensing of fungal infection and host response, Chronic Inflammatory Disease and Immunotherapy. Specific Aim 3: To provide an opportunity for young investigators and trainees to interact closely with well-established researchers in their fields and to present their research in poster or oral presentations. Specific Aim 4: To provide an opportunity for women, under-represented minorities and persons with disabilities to participate in a meeting that showcases their work and facilitates interactions with other scientists in their fields.