Epithelial Stem Cells and their Niches

上皮干细胞及其生态位

• 批准号: 10540500
• 负责人: Valerie Horsley
• 金额: $ 3万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540500
• 关键词: Acute; Adult; Aging; Animal Model; Animals; Area; Asia; Australia; Biological Models; Biology; Biomedical Engineering; COVID-19; Cells; China; Clinic; Collaborations; Communication; Complex; Cornea; DNA Repair; Data; Development; Disease; Disease model; Environment; Epidermis; Epithelial; Epithelial Cells; Europe; Fertilization; Floor; Fostering; Generations; Goals; Growth; Homeostasis; Hong Kong; Human; Image; India; Injury; Intestines; Japan; Korea; Life; Location; Lung; Malignant Neoplasms; Mammary gland; Medical; Mission; Molecular; Mus; Oral; Organ; Organism; Organoids; Participant; Postdoctoral Fellow; Prostate; Regenerative Medicine; Regulation; Regulatory Pathway; Research; Research Personnel; Scientist; Signal Transduction; Singapore; Skin; Source; Stem Cell Research; Stomach; Structure; Students; System; Systems Biology; Techniques; Technology; Tissue Engineering; Tissues; Training; Transplantation; Work; appendage; career; cell type; comparative; craniofacial complex; epigenetic regulation; epithelial stem cell; epithelium regeneration; field study; fighting; graduate student; immunoregulation; in vivo; injury and repair; interest; meetings; news; next generation; peer; posters; programs; regenerative; repaired; self-renewal; single cell analysis; stem cell function; stem cells; symposium; synergism; three dimensional cell culture; tissue stem cells

Abstract Adult epithelia regenerate during adult life due to the constant activity of stem cell pools. Stem cells maintain tissue homeostasis and repair injury by close communication with their tissue environment, known as "niche". Niches are complex, structured arrays of different cell types that guide tissue stem cell dynamics. The ultimate goal of understanding epithelial stem cell regulation is to repair or replace cells or organs damaged by injury, disease, and aging. The strategies vary from generating cell types and tissues in a dish for transplantation purposes, to directly stimulating the damaged organ in the living organism. This field has been exponentially growing for the past decade. Tissues such as human skin and cornea have already been grown in 3D cultures and used in clinics to fight otherwise incurable medical conditions. The GRC "Epithelial Stem Cells and their Niches” will focus on comparative principles of adult epithelial stem cell dynamics and niche signaling in the homeostasis of different tissues. This conference will include work on the molecular control of stem cell function from the epidermis and its appendages, intestine, lung, mammary gland, cornea, prostate, and emerging work from other epithelial tissues. All model organisms are welcome. This GRC has held two meetings in 2016 and 2018 and was cancelled in 2020 due to COVID-19. We hope to continue to build a principle of alternating speakers that will allow a variety of participants to contribute to this exciting meeting over the coming years. In particular for the 2022 meeting, we have built a scientific program that emphasizes key cutting-edge areas in epithelial biology including organoid techniques, imaging and single cell analysis, bioengineering, systems biology, modeling disease, DNA repair, aging and epigenetic regulation. In addition, we will support the attendance of graduate students, post docs, and early career scientists as they make their way into this exciting field of study by hosting a GRS in the two days prior to this GRC. A critical feature of the GRC’s scientific mission is to engage the next generation of scientists. We are introducing a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows that will precede this GRC. The GRS will allow students and fellows to share and discuss unpublished data and technical breakthroughs, favouring collaborative efforts and sparking provocative hypotheses to be discussed on the floor of the main conference. Furthermore, the participants will have the opportunity to establish tight professional relationships from which they will benefit throughout their career. GRS participants will be expected to stay for the GRC, further contributing to the educational value of this conference.

摘要 由于干细胞的持续活性，成人上皮细胞在成人期再生 池.干细胞维持组织稳态并通过密切的细胞间相互作用修复损伤。 与它们的组织环境进行通信，称为“小生境”。利基市场很复杂， 不同细胞类型的结构化阵列，指导组织干细胞动力学。的 理解上皮干细胞调节的最终目标是修复或替换 因损伤、疾病和衰老而受损的细胞或器官。这些策略各不相同， 在培养皿中产生用于移植目的的细胞类型和组织， 刺激生物体内受损的器官该领域 在过去的十年里呈指数增长。人体皮肤和角膜等组织 已经在3D培养中生长，并在诊所中用于对抗其他无法治愈的疾病。 医疗条件。GRC“上皮干细胞及其小生境”将重点关注 成人上皮干细胞动力学和小生境信号传导的比较原则， 不同组织的体内平衡这次会议将包括关于 来自表皮及其附属物的干细胞功能的分子控制， 肠、肺、乳腺、角膜、前列腺和其他新兴工作 上皮组织所有的模式生物都欢迎。这个集选区委员会曾举行两次会议， 于2016年及2018年已注销，并因2019冠状病毒病于2020年注销。我们希望继续 建立一个交替发言的原则，允许各种参与者 在未来几年为这一激动人心的会议做出贡献。特别是2022年 会议上，我们建立了一个科学计划，强调关键的尖端领域 在上皮生物学中，包括类器官技术、成像和单细胞分析， 生物工程，系统生物学，疾病建模，DNA修复，衰老和表观遗传 调控此外，我们将支持研究生，博士后， 和早期的职业科学家，因为他们进入这个令人兴奋的研究领域， 在此GRC之前的两天内举办GRS。 GRC科学使命的一个关键特征是让下一代 科学家我们将举办为期两天的戈登研究研讨会（GRS）， 研究生和博士后研究员，将在此GRC。GRS将 允许学生和研究员分享和讨论未发表的数据和技术 突破，有利于合作努力和引发挑衅性的假设 将在主会场讨论。与会者还 将有机会建立紧密的专业关系， 将在整个职业生涯中受益。预计GRS参与者将在 GRC，进一步促进本次会议的教育价值。