Defining the role of lymphatic vessels in wound healing

项目总结 皮肤的血管系统就像网络携带的维持皮肤的因子 动态平衡，并在受伤或损害发生时改变免疫反应。当 血管系统变得功能失调，像皮肤伤口愈合受到阻碍。这个 血管系统由相互作用以提供循环的血管和淋巴管组成 以及对皮肤健康至关重要的细胞。血管功能障碍可以用血过多来表征 血管，损伤部位免疫细胞浸润减少，和/或血管过多 发展。我的实验室最近描述了淋巴管的作用，它的任务是穿梭 皮肤中的白细胞和淋巴，在介导血管增多的表型中，偶联 有纤维化，在皮肤受伤后。据报道，淋巴管对皮肤有重要作用。 然而，修复的确切功能和作用机制还没有得到很好的描述。我们 建议不仅要探索皮肤内淋巴管的功能，还要研究它们之间的相互作用 将允许对伤口愈合的方式进行概念化 慢性的和不成功的，以及更远的，这种向不稳定的血管系统的转变如何调节 形成纤维化、疤痕组织和淋巴水肿。

Project summary The vasculature of the skin behaves as network carrying factors which maintain skin homeostasis and modify the immune response when injury or damage occurs. When the vasculature becomes dysfunctional processes like skin wound healing are hindered. The vasculature consists of blood vessels and lymphatic vessels interacting to provide circulation and cells crucial for skin health. Vascular dysfunction can be characterized by leavy blood vessels, decreased immune cell infiltrate at the site of injury, and/or excessive blood vessel development. My laboratory recently described a role of lymphatic vessels, tasked with shuttling leukocytes and lymph throughout the skin, in mediating a hypervascular phenotype, coupled with fibrosis, after skin injury. Lymphatic vessels have been reported as instrumental for skin repair however the precise function and mechanism of action are not well characterized. We suggest exploration of not only lymphatic vessel function within the skin but also their interaction with blood vessels will allow for a conceptualization of how wound healing can be rendered chronic and unsuccessful and further, how this shift towards an erratic vasculature mediates the formation of fibrotic, scarred tissue and lymphedema.