Defining the role of lymphatic vessels in wound healing
定义淋巴管在伤口愈合中的作用
基本信息
- 批准号:10748605
- 负责人:
- 金额:$ 9.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AffectBlood VesselsCellsCessation of lifeChronicCicatrixCirculationCoupledDevelopmentDiseaseFibrosisHealthHomeostasisHypervascularImmune responseImpaired wound healingIndividualInjuryLaboratoriesLeukocytesLymphLymphedemaMediatingModelingNatureOrganPhenotypeProcessQuality of lifeReportingRoleSiteSkinSkin injurySkin repairSkin wound healingSwellingSymptomsTissuesVascular Diseasesblood vessel developmentimmune cell infiltrateimprovedlymphatic vesselwound healing
项目摘要
Project summary
The vasculature of the skin behaves as network carrying factors which maintain skin
homeostasis and modify the immune response when injury or damage occurs. When the
vasculature becomes dysfunctional processes like skin wound healing are hindered. The
vasculature consists of blood vessels and lymphatic vessels interacting to provide circulation
and cells crucial for skin health. Vascular dysfunction can be characterized by leavy blood
vessels, decreased immune cell infiltrate at the site of injury, and/or excessive blood vessel
development. My laboratory recently described a role of lymphatic vessels, tasked with shuttling
leukocytes and lymph throughout the skin, in mediating a hypervascular phenotype, coupled
with fibrosis, after skin injury. Lymphatic vessels have been reported as instrumental for skin
repair however the precise function and mechanism of action are not well characterized. We
suggest exploration of not only lymphatic vessel function within the skin but also their interaction
with blood vessels will allow for a conceptualization of how wound healing can be rendered
chronic and unsuccessful and further, how this shift towards an erratic vasculature mediates the
formation of fibrotic, scarred tissue and lymphedema.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Valerie Horsley其他文献
Valerie Horsley的其他文献
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{{ truncateString('Valerie Horsley', 18)}}的其他基金
Defining the role of lymphatic vessels in wound healing
定义淋巴管在伤口愈合中的作用
- 批准号:
10596468 - 财政年份:2021
- 资助金额:
$ 9.08万 - 项目类别:
Defining the role of lymphatic vessels in wound healing
定义淋巴管在伤口愈合中的作用
- 批准号:
10362707 - 财政年份:2021
- 资助金额:
$ 9.08万 - 项目类别:
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