Defining the role of lymphatic vessels in wound healing

定义淋巴管在伤口愈合中的作用

• 批准号: 10748605
• 负责人: Valerie Horsley
• 金额: $ 9.08万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10748605
• 关键词: Affect; Blood Vessels; Cells; Cessation of life; Chronic; Cicatrix; Circulation; Coupled; Development; Disease; Fibrosis; Health; Homeostasis; Hypervascular; Immune response; Impaired wound healing; Individual; Injury; Laboratories; Leukocytes; Lymph; Lymphedema; Mediating; Modeling; Nature; Organ; Phenotype; Process; Quality of life; Reporting; Role; Site; Skin; Skin injury; Skin repair; Skin wound healing; Swelling; Symptoms; Tissues; Vascular Diseases; blood vessel development; immune cell infiltrate; improved; lymphatic vessel; wound healing

Project summary The vasculature of the skin behaves as network carrying factors which maintain skin homeostasis and modify the immune response when injury or damage occurs. When the vasculature becomes dysfunctional processes like skin wound healing are hindered. The vasculature consists of blood vessels and lymphatic vessels interacting to provide circulation and cells crucial for skin health. Vascular dysfunction can be characterized by leavy blood vessels, decreased immune cell infiltrate at the site of injury, and/or excessive blood vessel development. My laboratory recently described a role of lymphatic vessels, tasked with shuttling leukocytes and lymph throughout the skin, in mediating a hypervascular phenotype, coupled with fibrosis, after skin injury. Lymphatic vessels have been reported as instrumental for skin repair however the precise function and mechanism of action are not well characterized. We suggest exploration of not only lymphatic vessel function within the skin but also their interaction with blood vessels will allow for a conceptualization of how wound healing can be rendered chronic and unsuccessful and further, how this shift towards an erratic vasculature mediates the formation of fibrotic, scarred tissue and lymphedema.

项目摘要 皮肤的脉管系统表现为携带维持皮肤的因子的网络 当损伤或损害发生时，免疫系统可以调节体内平衡并改变免疫反应。当 脉管系统变得功能障碍，如皮肤伤口愈合受到阻碍。的 脉管系统由相互作用以提供循环的血管和淋巴管组成 和对皮肤健康至关重要的细胞。血管功能障碍的特点是血液中 损伤部位免疫细胞浸润减少和/或血管过多 发展我的实验室最近描述了淋巴管的作用， 白细胞和淋巴细胞在整个皮肤中，在介导多血管表型， 皮肤损伤后纤维化。淋巴管已被报道为皮肤的工具 然而，修复的确切功能和作用机制还没有得到很好的表征。我们 建议不仅探索皮肤内的淋巴管功能，而且探索它们之间的相互作用 将允许概念化如何使伤口愈合 慢性和不成功的，并进一步，这种转变对一个不稳定的脉管系统如何介导 纤维化、瘢痕组织和水肿的形成。