Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize Healthspan

加强老年科学奖学金和教师发展,以最大限度地减少虚弱和最大限度地延长健康寿命

基本信息

  • 批准号:
    10349503
  • 负责人:
  • 金额:
    $ 15.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-05-15 至 2023-01-31
  • 项目状态:
    已结题

项目摘要

Aging is the single most important risk factor for comorbidity and frailty. Frailty increases the risk of poor outcomes that include falls, incident disability, hospitalization and mortality. Healthspan is the number of years lived in a healthy, vital, and functionally capable state. Frailty and healthspan exist, then, in opposition among the elderly and are at the core of optimal geriatric care. This NIA K07 Academic Leadership Career Award will support Dr. Troen’s ongoing career development and help to protect his time and effort to build the research support and mentorship infrastructure for the Center for Successful Aging (CSA), which focuses on geroscience-related research and education at the University at Buffalo (UB). The goals of this proposal are 1) to advance innovative interdisciplinary and interprofessional collaborative research to detect, understand, and minimize frailty and maximize healthspan in older adults and 2) to establish a robust mentorship, educational, and research environment that fosters development of successful interdisciplinary geroscience and geriatrics investigators. These goals will be accomplished through the candidate’s committed efforts and leadership of the CSA, the breaking down of silos, and meaningful collaboration with the multitude of existing resources for interdisciplinary research and interprofessional education and collaborative practice at UB. Aging-related and geriatric research capacity will be enhanced through active recruitment of investigators, partnerships with centers and departments across the entire university, a pilot grant program, and an annual research retreat. This will enhance interdisciplinary research, establish an optimal environment for mentorship, and support development and competing for extramural grants. Faculty development and mentorship will be supported through mentorship committees, a new geroscience curriculum, regular seminars, and an emphasis on interdisciplinary research and training opportunities. The candidate has the necessary scientific expertise, leadership skills, clinical and research training, and mentoring and teaching experience to lead the CSA, implement a program of curriculum development, and accomplish the stated aims of this proposal. He will build on existing infrastructure at UB to develop and train a diverse pool of highly- trained scientists who will conduct important research to Minimize Frailty and Maximize Healthspan. This application holds great promise in developing an interdisciplinary research and mentoring program that transcends traditional boundaries and that will enhance knowledge and ultimately improve the care of the aging population.
衰老是导致共病和虚弱的唯一最重要的危险因素。虚弱会增加贫穷的风险 结果包括跌倒、意外伤残、住院和死亡率。Health Span是指 多年来生活在健康、充满活力和功能健全的状态中。那么,虚弱和健康是对立的。 在老年人中,并处于最佳老年保健的核心。NIA K07学术领导力生涯 奖励将支持特罗恩博士正在进行的职业发展,并帮助保护他的时间和努力建立 成功老龄化中心(CSA)的研究支持和指导基础设施,重点是 布法罗大学(UB)与老年学相关的研究和教育。这项提议的目标是 1)推进创新的跨学科和跨专业的协作研究,以发现、理解、 并在老年人中最大限度地减少虚弱和最大限度地延长健康时间,以及2)建立健全的导师关系, 促进成功的跨学科老年科学发展的教育和研究环境 以及老年病研究人员。这些目标将通过候选人的坚定努力和 CSA的领导力、打破孤岛以及与众多现有的 多伦多大学跨学科研究、跨专业教育和协作实践资源。 将通过积极招聘研究人员来加强与老龄化和老年学有关的研究能力, 与整个大学的中心和院系建立伙伴关系,试点助学金计划,以及年度 研究休养地。这将加强跨学科研究,为 指导、支持发展和竞争校外赠款。教师发展和 指导将通过指导委员会得到支持,这是一种新的老年学课程,定期 研讨会,并强调跨学科研究和培训机会。这位候选人拥有 必要的科学专业知识、领导技能、临床和研究培训以及指导和教学 具有领导CSA、实施课程开发计划并实现所述目标的经验 这项提议。他将在UB现有基础设施的基础上,开发和培训一批高度- 训练有素的科学家,他们将进行重要的研究,以最大限度地减少脆弱性和最大化健康寿命。这 应用程序在开发跨学科研究和指导计划方面大有可为, 超越了传统的界限,这将增加知识,并最终改善对 人口老龄化。

项目成果

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Bruce R. Troen其他文献

Effects of a 6-Week Treadmill Training With and Without Virtual Reality on Frailty in People With Multiple Sclerosis
为期6周有虚拟现实和无虚拟现实的跑步机训练对多发性硬化症患者虚弱状况的影响
  • DOI:
    10.1016/j.apmr.2024.09.010
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    3.700
  • 作者:
    Tobia Zanotto;Irina Galperin;Danya Pradeep Kumar;Anat Mirelman;Shahar Yehezkyahu;Keren Regev;Arnon Karni;Tanja Schmitz-Hübsch;Friedemann Paul;Sharon G. Lynch;Abiodun E. Akinwuntan;Jianghua He;Bruce R. Troen;Hannes Devos;Jeffrey M. Hausdorff;Jacob J. Sosnoff
  • 通讯作者:
    Jacob J. Sosnoff
Comparative Responsiveness of HL-60, HL-60R, and HL-60R<sup>+</sup> (LRARSN) Cells to Retinoic Acid, Calcitriol, 9 <em>cis</em>-Retinoic Acid, and Sodium Butyrate
  • DOI:
    10.1182/blood.v86.7.2475.2475
  • 发表时间:
    1995-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kevin B. Atkins;Bruce R. Troen
  • 通讯作者:
    Bruce R. Troen
Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.
转化小鼠成纤维细胞主要分泌蛋白基因的克隆和表达。
  • DOI:
    10.1016/s0021-9258(19)57386-0
  • 发表时间:
    1988
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Bruce R. Troen;D. Ascherman;Daphne Atlas;Michael M. Gottesman
  • 通讯作者:
    Michael M. Gottesman
Resveratrol: Effects on Lipids and Cardiovascular Risk
白藜芦醇:对血脂和心血管风险的影响
  • DOI:
    10.1007/s12170-012-0289-2
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    1.9
  • 作者:
    E. Cherniack;E. Cherniack;Bruce R. Troen;Bruce R. Troen
  • 通讯作者:
    Bruce R. Troen

Bruce R. Troen的其他文献

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{{ truncateString('Bruce R. Troen', 18)}}的其他基金

Promoting cognitive resilience and reducing frailty in older Veterans with bright light therapy
通过强光疗法提高老年退伍军人的认知能力并减少虚弱
  • 批准号:
    10590503
  • 财政年份:
    2023
  • 资助金额:
    $ 15.12万
  • 项目类别:
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
高强度间歇训练(HIIT)可减少老年退伍军人的虚弱并增强其恢复能力
  • 批准号:
    10539160
  • 财政年份:
    2023
  • 资助金额:
    $ 15.12万
  • 项目类别:
The impacts of vitamin D status and HIIT on physical performance and frailty during aging
维生素 D 状态和 HIIT 对衰老过程中身体机能和虚弱的影响
  • 批准号:
    10229660
  • 财政年份:
    2020
  • 资助金额:
    $ 15.12万
  • 项目类别:
ShEEP Request for Intracellular and Extracellular Protein Signaling Station (IEPSS)
ShEEP 请求细胞内和细胞外蛋白质信号转导站 (IEPSS)
  • 批准号:
    10178936
  • 财政年份:
    2020
  • 资助金额:
    $ 15.12万
  • 项目类别:
Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize Healthspan
加强老年科学奖学金和教师发展,以最大限度地减少虚弱和最大限度地延长健康寿命
  • 批准号:
    9927970
  • 财政年份:
    2019
  • 资助金额:
    $ 15.12万
  • 项目类别:
High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging
高强度间歇训练和烟酰胺核苷治疗可增强功能能力并减少衰老过程中的虚弱
  • 批准号:
    10663245
  • 财政年份:
    2019
  • 资助金额:
    $ 15.12万
  • 项目类别:
Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize Healthspan
加强老年科学奖学金和教师发展,以最大限度地减少虚弱和最大限度地延长健康寿命
  • 批准号:
    10581712
  • 财政年份:
    2019
  • 资助金额:
    $ 15.12万
  • 项目类别:
High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging
高强度间歇训练和烟酰胺核苷治疗可增强功能能力并减少衰老过程中的虚弱
  • 批准号:
    10266089
  • 财政年份:
    2019
  • 资助金额:
    $ 15.12万
  • 项目类别:
High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging
高强度间歇训练和烟酰胺核苷治疗可增强功能能力并减少衰老过程中的虚弱
  • 批准号:
    9974279
  • 财政年份:
    2019
  • 资助金额:
    $ 15.12万
  • 项目类别:
ShEEP Request for Keyence BZ-X800E All-in-One Fluorescence Microscope
ShEEP 请求购买 Keyence BZ-X800E 一体式荧光显微镜
  • 批准号:
    9907801
  • 财政年份:
    2019
  • 资助金额:
    $ 15.12万
  • 项目类别:

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