Training Program in Resuscitation Science

摘要 我们的目标是在复苏科学的新兴领域提供先进的多学科研究培训， 医生和博士科学家，以启动他们的发展，以独立的研究人员。复苏 科学在该提议中被定义为缺血-灌注损伤的医学治疗（即，心脏骤停）， 冲击（即，组织低灌注）、急性肺损伤和随后的其他器官损伤，例如肾损伤。 损伤总的来说，这些疾病每年折磨着数百万患者，并且与高血压相关。 死亡率和发病率很高。拟议中的计划将有助于缓解训练有素的 以及资金充足的复苏科学研究者最重要的是，跨学科的研究培训提供了 由于共同的风险， 需要复苏的病症共有的因素、致病机制和结果表型。的 强大的多学科教师/导师T32计划团队由复苏科学家组成，他们擅长 在研究和指导方面。他们的专业知识涵盖急诊医学，心脏病学， 肾脏病学，以及肺部重症监护，麻醉重症监护，外科重症监护和儿科重症监护 在乎导师团队进行的研究使用了广泛的方法，包括临床 试验，流行病学/数据科学和实验室科学，许多导师结合两个或更多 接近。我们计划的学员将把他们的研究培训集中在这些方法之一;所有人都将 但接受了所有这三种方法初步培训和多学科接触。NHLBI已经 注意到这种整合对于公共卫生的突破性进展至关重要[1]，我们强调这一点 这一点将产生真正的多学科，在许多情况下翻译调查。具体奖学金 培训将联合收割机与正式的教学课程和指导项目相结合，即研究培训 沟通和职业指导。教学计划将借鉴哈佛催化剂运行的课程 （CTSA），哈佛公共卫生学院和复苏科学中心，并将包括所需的 共同的和特定轨道的核心课程和选修课程。每个研究员的课程将分别 量身定制，以匹配个人目标和与指导团队一起制定的目标。个性化 导师指导的研究项目将由研究员在他或她的主要指导下设计和执行。 在项目教师的其他成员的帮助下进行指导。将鼓励研究员合作 与导师和研究员以外的他们选择的轨道，以扩大他们的研究专长。培训 通过会议报告和研究论文交流研究成果，撰写赠款，以及 一般性职业发展建议将是对核心研究培训的宝贵补充。完成时 该计划的研究员将有望满足定义的指标-多个摘要介绍，手稿 出版物和拨款申请-所有这些都是他们走向研究独立的关键步骤。

Abstract We aim to provide advanced multidisciplinary research training in the emerging field of resuscitation science to physician- and PhD-scientists to jump-start their progression to independence as investigators. Resuscitation science is defined in this proposal as the medical treatment of ischemia-perfusion injury (i.e., cardiac arrest), shock (i.e., tissue hypo-perfusion), acute lung injury, and subsequent other-organ injury such as renal impairment. Collectively, these conditions afflict millions of patients every year and are associated with high mortality and substantial morbidity. The proposed program will help alleviate a critical shortage of well-trained and well-funded resuscitation science investigators. Most critically, the cross-discipline research training afforded to program trainees should make them well-positioned to advance the field as a whole due to the common risk factors, pathogenic mechanisms, and outcome phenotypes shared by conditions requiring resuscitation. The strong multidisciplinary faculty/mentorship T32 program team is comprised of resuscitation scientists who excel in both research and mentorship. Their expertise spans the fields of emergency medicine, cardiology, nephrology, as well as pulmonary critical care, anesthesia critical care, surgical critical care, and pediatric critical care. Research conducted by the mentorship team uses a wide spectrum of approaches which include clinical trials, epidemiology/data science, and laboratory science, with many mentors combining two or more approaches. Trainees in our program will focus their research training in one of these approaches; all will however receive preliminary training in, and multidisciplinary exposure to, all three approaches. The NHLBI has noted this sort of integration is critical for breakthrough advances in public health [1], and our emphasis on this point will produce truly multidisciplinary, and in many cases translational investigators. The specific fellowship training will combine a formalized didactic curriculum with a mentored project, training in research communication, and career mentorship. The didactic program will draw from courses run by Harvard Catalyst (CTSA), the Harvard School of Public Health, and the Center for Resuscitation Science and will include required common and track-specific core courses and elective courses. Each fellow’s coursework will be individually tailored to match personal objectives and goals developed with the mentorship team. The individualized mentored research project will be designed and executed by the fellow under the guidance of his or her primary mentor with assistance from other members of the program faculty. Fellows will be encouraged to collaborate with mentors and fellows outside of their chosen track to broaden their research expertise. Training in communication of research results through conference presentations and research papers, grant writing, and general career development advice will be valuable additions to the core research training. At the completion of this program fellows will be expected to meet defined metrics - multiple abstract presentations, manuscript publications, and grant submissions - all key steps in their path toward research independence.