Training Program in Resuscitation Science

摘要 我们的目标是在复苏科学的新兴领域提供先进的多学科研究培训 医生和博士科学家加速他们作为研究人员的独立进程。复苏 该提案中科学被定义为缺血灌注损伤（即心脏骤停）的医学治疗， 休克（即组织灌注不足）、急性肺损伤以及随后的其他器官损伤，例如肾损伤 损害。总的来说，这些疾病每年困扰着数百万患者，并且与高发病率相关。 死亡率和显着的发病率。拟议的计划将有助于缓解训练有素的人员的严重短缺 以及资金充足的复苏科学研究人员。最重要的是，提供的跨学科研究培训 由于共同的风险，对受训人员进行规划应该使他们处于有利地位，以推动整个领域的发展 需要复苏的病症共有的因素、致病机制和结果表型。的 强大的多学科师资/指导 T32 项目团队由出色的复苏科学家组成 在研究和指导方面。他们的专业知识涵盖急诊医学、心脏病学、 肾病科，以及肺部重症监护、麻醉重症监护、外科重症监护和儿科重症监护 关心。导师团队进行的研究采用了广泛的方法，包括临床 试验、流行病学/数据科学和实验室科学，许多导师结合了两种或多种 接近。我们项目的学员将集中研究其中一种方法的培训；一切都会 然而，接受所有这三种方法的初步培训和多学科接触。 NHLBI 有 指出这种整合对于公共卫生领域的突破性进展至关重要 [1]，我们对此的强调 点将产生真正的多学科、在许多情况下转化的研究者。具体奖学金 培训将把正式的教学课程与指导项目、研究培训相结合 沟通和职业指导。该教学计划将借鉴哈佛催化剂组织的课程 (CTSA)、哈佛大学公共卫生学院和复苏科学中心，并将包括所需的 公共和特定轨道的核心课程和选修课程。每个研究员的课程作业将是单独的 量身定制，以匹配个人目标以及与导师团队制定的目标。个性化的 指导研究项目将由研究员在其主要导师的指导下设计和执行 在该项目教师其他成员的帮助下进行指导。将鼓励研究员合作 与他们所选领域之外的导师和研究员合作，以拓宽他们的研究专业知识。培训于 通过会议演讲和研究论文、资助写作等方式交流研究成果 一般职业发展建议将是核心研究培训的宝贵补充。完成时 该计划的研究员将被期望达到定义的指标——多个摘要演示、手稿 出版物和资助申请——所有这些都是他们走向研究独立之路的关键步骤。

Abstract We aim to provide advanced multidisciplinary research training in the emerging field of resuscitation science to physician- and PhD-scientists to jump-start their progression to independence as investigators. Resuscitation science is defined in this proposal as the medical treatment of ischemia-perfusion injury (i.e., cardiac arrest), shock (i.e., tissue hypo-perfusion), acute lung injury, and subsequent other-organ injury such as renal impairment. Collectively, these conditions afflict millions of patients every year and are associated with high mortality and substantial morbidity. The proposed program will help alleviate a critical shortage of well-trained and well-funded resuscitation science investigators. Most critically, the cross-discipline research training afforded to program trainees should make them well-positioned to advance the field as a whole due to the common risk factors, pathogenic mechanisms, and outcome phenotypes shared by conditions requiring resuscitation. The strong multidisciplinary faculty/mentorship T32 program team is comprised of resuscitation scientists who excel in both research and mentorship. Their expertise spans the fields of emergency medicine, cardiology, nephrology, as well as pulmonary critical care, anesthesia critical care, surgical critical care, and pediatric critical care. Research conducted by the mentorship team uses a wide spectrum of approaches which include clinical trials, epidemiology/data science, and laboratory science, with many mentors combining two or more approaches. Trainees in our program will focus their research training in one of these approaches; all will however receive preliminary training in, and multidisciplinary exposure to, all three approaches. The NHLBI has noted this sort of integration is critical for breakthrough advances in public health [1], and our emphasis on this point will produce truly multidisciplinary, and in many cases translational investigators. The specific fellowship training will combine a formalized didactic curriculum with a mentored project, training in research communication, and career mentorship. The didactic program will draw from courses run by Harvard Catalyst (CTSA), the Harvard School of Public Health, and the Center for Resuscitation Science and will include required common and track-specific core courses and elective courses. Each fellow’s coursework will be individually tailored to match personal objectives and goals developed with the mentorship team. The individualized mentored research project will be designed and executed by the fellow under the guidance of his or her primary mentor with assistance from other members of the program faculty. Fellows will be encouraged to collaborate with mentors and fellows outside of their chosen track to broaden their research expertise. Training in communication of research results through conference presentations and research papers, grant writing, and general career development advice will be valuable additions to the core research training. At the completion of this program fellows will be expected to meet defined metrics - multiple abstract presentations, manuscript publications, and grant submissions - all key steps in their path toward research independence.