Mechanisms of cardiovascular disease

这是一份新的T32 Ruth L.Kirschstein机构国家研究报告的申请书 《心血管疾病的机制》服务奖。阿尔伯特·爱因斯坦 医学院，全国首批建立正式的 分子心血管生物学计划于1987年启动，具有悠久的传统 心血管研究培训。当代生物医学科学允许 遗传学、表观遗传学、分子生物学、生理学、模型系统的整合 研究和流行病学，以推动对心血管疾病的了解取得进展。 通过这些模式，我们可以开始了解精确的分子 预置和参与复杂过程的机制，例如 先天性心脏病、动脉粥样硬化、缺血性心脏病和心力衰竭。 我们项目的总体结构包括代表6个不同部门的11名培训员， 主题集中在1)心肌-损伤和衰老，2)血管 发展和疾病，以及3)代谢-心血管风险。的使命 这一计划是为了提供下一代调查人员，包括预审和 博士后实习生，拥有最先进的概念、经验和技能，需要 在心血管研究领域开创并保持成功的长期独立职业生涯。 作为这一计划的结果，科学家之间在基础领域工作的对话 生物学、基础心血管科学家和临床心脏病专家将得到加强， 带来了富有成效的合作和尖端研究。这个节目为我们带来了我们的 机构的相当深度、严谨的科学方法和创新的传统 以应对重要且高度流行的心血管问题。

This is an application for a new T32 Ruth L. Kirschstein Institutional National Research Service Award entitled Mechanisms of Cardiovascular Disease. The Albert Einstein College of Medicine, one of the first institutions in the nation to establish a formal Molecular Cardiovascular Biology Program in 1987, has a long tradition of cardiovascular research training. Contemporary biomedical science permits the integration of genetics, epigenetics, molecular biology, physiology, model systems research, and epidemiology to drive progress in understanding of cardiovascular disease. Through these modalities, we can begin to understand the precise molecular mechanisms that predispose to and are involved in complex processes such as congenital heart disease, atherosclerosis, ischemic heart disease, and heart failure. Our program's overall structure includes 11 trainers representing 6 different departments, with areas of thematic focus in 1) Myocardium – Injury and Aging, 2) Vascular Development and Disease, and 3) Metabolism – Cardiovascular Risk. The mission of this program is to provide the next generation of investigators, including both pre- and postdoctoral trainees, with state-of-the art concepts, experiences, and skills required to initiate and sustain successful long-term independent careers in cardiovascular research. As a result of this program, dialogues among scientists working in fundamental areas of biology, basic cardiovascular scientists, and clinical cardiologists will be enhanced, leading to productive collaborations and cutting-edge research. This program brings our institution's considerable depth, rigorous scientific approach, and tradition of innovation to bear on important and highly prevalent cardiovascular problems.