Mechanisms of cardiovascular disease

心血管疾病的机制

• 批准号: 10546496
• 负责人: Richard N Kitsis
• 金额: $ 20.76万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10546496
• 关键词: Cardiovascular Diseases

This is an application for a new T32 Ruth L. Kirschstein Institutional National Research Service Award entitled Mechanisms of Cardiovascular Disease. The Albert Einstein College of Medicine, one of the first institutions in the nation to establish a formal Molecular Cardiovascular Biology Program in 1987, has a long tradition of cardiovascular research training. Contemporary biomedical science permits the integration of genetics, epigenetics, molecular biology, physiology, model systems research, and epidemiology to drive progress in understanding of cardiovascular disease. Through these modalities, we can begin to understand the precise molecular mechanisms that predispose to and are involved in complex processes such as congenital heart disease, atherosclerosis, ischemic heart disease, and heart failure. Our program's overall structure includes 11 trainers representing 6 different departments, with areas of thematic focus in 1) Myocardium – Injury and Aging, 2) Vascular Development and Disease, and 3) Metabolism – Cardiovascular Risk. The mission of this program is to provide the next generation of investigators, including both pre- and postdoctoral trainees, with state-of-the art concepts, experiences, and skills required to initiate and sustain successful long-term independent careers in cardiovascular research. As a result of this program, dialogues among scientists working in fundamental areas of biology, basic cardiovascular scientists, and clinical cardiologists will be enhanced, leading to productive collaborations and cutting-edge research. This program brings our institution's considerable depth, rigorous scientific approach, and tradition of innovation to bear on important and highly prevalent cardiovascular problems.

这是一个新的T32露丝L的应用程序。Kirschstein Institutional National Research 心血管疾病机制服务奖。阿尔伯特·爱因斯坦 医学院，在全国首批机构之一，建立一个正式的 分子心血管生物学计划于1987年，具有悠久的传统， 心血管研究训练现代生物医学科学允许 遗传学、表观遗传学、分子生物学、生理学、模型系统的整合 研究和流行病学来推动对心血管疾病的理解。 通过这些方式，我们可以开始了解 易诱发并参与复杂过程的机制，如 先天性心脏病、动脉粥样硬化、缺血性心脏病和心力衰竭。 我们计划的整体结构包括11名培训师，代表6个不同的部门， 主题重点领域为：1）肌肉-损伤和衰老，2）血管 发展和疾病，和3）代谢-心血管风险。的使命 该计划是为了提供下一代的调查，包括前和 博士后培训生，具有最先进的概念，经验和技能， 在心血管研究领域开创并维持成功的长期独立职业生涯。 由于这一计划，在基础领域工作的科学家之间的对话， 生物学、基础心血管科学家和临床心脏病专家将得到加强， 导致富有成效的合作和前沿研究。这个节目带来了我们的 该机构相当的深度，严谨的科学方法和创新的传统 对重要的和高度流行的心血管问题产生影响。