CORE 1: Data Management and Bioinformatics Core
核心 1:数据管理和生物信息学核心
基本信息
- 批准号:10549998
- 负责人:
- 金额:$ 14.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-17 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectBioinformaticsBiologicalCell modelCellsChromosome MappingComputer softwareDataData AnalysesData SetDatabasesDevelopmentDiseaseEcosystemEnsureGeneticHumanInfrastructureIntegration Host FactorsIntuitionJournalsLinkMapsMissionModelingMolecularOntologyPathway interactionsPeer ReviewPerformanceProteinsProteomicsPublicationsPublishingReproducibilityResearchResearch PersonnelResourcesSiteSoftware ToolsSourceSupercomputingTuberculosisVisualVisualizationbacterial geneticscandidate validationdata and analysis portaldata exchangedata integrationdata managementdigital object identifierdisease prognosisgenetic informationgenome wide association studynetwork modelsnovelpathogenrespiratory virustargeted treatmenttooltranscriptomicsweb portalweb site
项目摘要
DATA MANAGEMENT AND BIOINFORMATICS CORE
SUMMARY
The HPMI Data Management and Bioinformatics Core will support the Center's mission in all stages of
research and publication, facilitating reproducible analysis, visualization, and access to center data and results.
The Core will be composed of four major components: software and analysis workflows for data integration
the Cytoscape and the Cytoscape Ecosystem; the Network Data Exchange (NDEx); and the HPMI Data and
Analysis Portal. First, we will develop workflows to integrate proteomics, transcriptomics, genetics, and
functional data generated by Projects 1 and 2 with existing -omics and GWAS datasets to select host factor
candidates for validation. Second, Cytoscape will provide a range of tools for analyzing and visualizing
molecular networks, interaction data, and hierarchical network models from both Projects. The third
component, NDEx, will provide database infrastructure to support the sharing, reviewing, and disseminating of
network data and models. It will also enable consolidated access to public biological network resources for use
by HPMI investigators. Finally, the HPMI Data and Analysis Portal will provide a common access point for
software tools and pipelines and their associated data. The above components – software and analysis
workflows for data integration, visual network maps in Cytoscape, and storage of networks and models in
NDEx – will all be made accessible through the HPMI’s website. Additionally, publications using HPMI products
will be enhanced by the recent additions to Cytoscape for dynamically embedding network data in peer-
reviewed journals. Finally, the Core will draw on an impressive array of hardware infrastructure for
supercomputing, including high performance clusters at multiple sites.
数据管理和生物信息学核心
摘要
HPMI数据管理和生物信息学核心将在以下所有阶段支持中心的使命
研究和出版,促进可重现的分析、可视化和访问中心数据和结果。
核心将由四个主要组成部分组成:用于数据集成的软件和分析工作流
细胞景观和细胞景观生态系统;网络数据交换(NDX);HPMI数据和
分析门户。首先,我们将开发工作流程,将蛋白质组学、转录组学、遗传学和
由项目1和项目2生成的功能数据与现有的组学和GWAS数据集一起选择宿主因素
需要验证的候选人。其次,Cytosscape将提供一系列分析和可视化工具
来自两个项目的分子网络、相互作用数据和分层网络模型。第三
组件NDeX将提供数据库基础设施,以支持共享、审查和传播
网络数据和模型。它还将实现对公共生物网络资源的统一访问以供使用
由HPMI调查人员提供。最后,HPMI数据和分析门户将为
软件工具和管道及其关联数据。上述组件--软件和分析
用于数据集成的工作流、Cytosscape中的可视化网络图以及中的网络和模型存储
NDX-将通过HPMI的网站访问所有内容。此外,使用HPMI产品的出版物
将通过最近添加到Cytoscape的功能得到增强,该功能用于在对等设备中动态嵌入网络数据
审阅了期刊。最后,核心将利用一系列令人印象深刻的硬件基础设施来实现
超级计算,包括多个站点的高性能集群。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ANDREJ SALI', 18)}}的其他基金
TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular Neighborhoods
TR
- 批准号:
10401763 - 财政年份:2014
- 资助金额:
$ 14.41万 - 项目类别:
TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular Neighborhoods
TR
- 批准号:
10621361 - 财政年份:2014
- 资助金额:
$ 14.41万 - 项目类别:
DEVELOPMENT AND TESTING OF MODELLER, AND RELATED TOOLS, ON THE ALPHA PLATFORM
在 ALPHA 平台上开发和测试 MODELER 及相关工具
- 批准号:
8363599 - 财政年份:2011
- 资助金额:
$ 14.41万 - 项目类别:
DETERMINATION OF THE PSEUDO-ATOMIC STRUCTURE OF NUCLEAR PORE COMPLEX (NPC) COMPO
核孔复合体(NPC)复合物拟原子结构的测定
- 批准号:
8362329 - 财政年份:2011
- 资助金额:
$ 14.41万 - 项目类别:
COMPUTATIONAL MODELING OF THE STRUCTURE OF THE SPINDLE POLE BODY CORE
主轴极体铁芯结构的计算模型
- 批准号:
8365787 - 财政年份:2011
- 资助金额:
$ 14.41万 - 项目类别:
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