CORE 1: Data Management and Bioinformatics Core

数据管理和生物信息学核心 总结 HPMI数据管理和生物信息学核心将支持中心的使命的所有阶段， 研究和出版，促进可重复的分析，可视化和访问中心数据和结果。 核心将由四个主要部分组成：软件和数据整合分析工作流程 Cytoscape和Cytoscape生态系统;网络数据交换（NDEx）; HPMI数据和 分析门户。首先，我们将开发整合蛋白质组学、转录组学、遗传学和 项目1和2使用现有组学和GWAS数据集生成的功能数据，用于选择宿主因子 候选人进行验证。其次，Cytoscape将提供一系列分析和可视化工具 分子网络，相互作用数据，以及两个项目的层次网络模型。第三 NDEx将提供数据库基础设施，以支持共享、审查和传播 网络数据和模型。它还将使人们能够统一利用公共生物网络资源， HPMI调查员。最后，HPMI数据和分析门户将为以下方面提供一个通用访问点： 软件工具和管道及其相关数据。上述组件-软件和分析 Cytoscape中的数据集成、可视化网络地图以及 NDEx -都将通过HPMI的网站访问。此外，使用HPMI产品的出版物 将通过最近添加到Cytoscape中以动态地将网络数据嵌入到对等网络中来增强， 审查期刊。最后，核心将利用一系列令人印象深刻的硬件基础设施， 超级计算，包括多个站点的高性能集群。

DATA MANAGEMENT AND BIOINFORMATICS CORE SUMMARY The HPMI Data Management and Bioinformatics Core will support the Center's mission in all stages of research and publication, facilitating reproducible analysis, visualization, and access to center data and results. The Core will be composed of four major components: software and analysis workflows for data integration the Cytoscape and the Cytoscape Ecosystem; the Network Data Exchange (NDEx); and the HPMI Data and Analysis Portal. First, we will develop workflows to integrate proteomics, transcriptomics, genetics, and functional data generated by Projects 1 and 2 with existing -omics and GWAS datasets to select host factor candidates for validation. Second, Cytoscape will provide a range of tools for analyzing and visualizing molecular networks, interaction data, and hierarchical network models from both Projects. The third component, NDEx, will provide database infrastructure to support the sharing, reviewing, and disseminating of network data and models. It will also enable consolidated access to public biological network resources for use by HPMI investigators. Finally, the HPMI Data and Analysis Portal will provide a common access point for software tools and pipelines and their associated data. The above components – software and analysis workflows for data integration, visual network maps in Cytoscape, and storage of networks and models in NDEx – will all be made accessible through the HPMI’s website. Additionally, publications using HPMI products will be enhanced by the recent additions to Cytoscape for dynamically embedding network data in peer- reviewed journals. Finally, the Core will draw on an impressive array of hardware infrastructure for supercomputing, including high performance clusters at multiple sites.