Core A- Administration, Education, and Mentoring

核心 A- 管理、教育和指导

• 批准号: 10553865
• 负责人: MICHAEL R GARRETT
• 金额: $ 56.84万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-06 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553865
• 关键词: Address; Advisory Committees; Area; Bioinformatics; Biometry; Cause of Death; Centers of Research Excellence; Charge; Chronic Disease; Collaborations; Complement; Computational Biology; Core Facility; Creativeness; Data Set; Diabetes Mellitus; Disease; Disease Progression; Early Intervention; Education; Ensure; Environment; Evaluation; Extramural Activities; Faculty; Feedback; Fostering; Funding; Genes; Genetic Predisposition to Disease; Genomics; Goals; Grant; Health; Heart Diseases; Individual; Infrastructure; Institution; Investigation; Kidney Diseases; Leadership; Medical; Medical center; Mentors; Mentorship; Methodology; Mission; Mississippi; Molecular; National Institute of General Medical Sciences; Onset of illness; Organism; Phase; Physiological; Physiology; Pilot Projects; Policies; Population; Program Development; Proteomics; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Socioeconomic Status; Stroke; Structure; Systems Biology; Teacher Professional Development; Technology; Training; United States; Universities; Whole Organism; Work; career; diet and exercise; early-career faculty; improved; individualized medicine; innovation; insight; lipidomics; meetings; member; metabolomics; multidisciplinary; new technology; novel; pathogen; programs; recruit; transcriptomics

Core A- Abstract The goal of the Molecular Center of Health and Disease (MCHD), a new Phase I COBRE, is to facilitate research under a central theme of molecular physiology to enhance the depth of education, mentorship, and training of researchers to generate unique opportunities to apply omics technology and computational biology across the health-disease continuum. While chronic diseases can be treated, an understanding of genetic susceptibility and molecular mechanisms involved in disease onset has the potential to halt progression and return an individual to a more healthy state. The integration of genomic, transcriptomic, proteomic, and metabolomic datasets with physiological information using computational approaches can provide novel insight into the molecular, cellular, and overall physiology associated with the health-disease continuum. The MCHD will be comprised of multiple components including an administrative unit, education and mentoring programs, a pilot project program, two research cores, and three major project investigators. In particular, Core A- Administration, Education, and Mentoring will be charged with promoting the mission of the MCHD to facilitate the use of innovative approaches to study health, onset and progression of disease, and interaction with pathogens, with the goal of understanding the breadth of information from the molecular level to the whole organism. Core A will provide administrative support, coordinate activities of research cores (including Core B- Omics and Gene-Editing and Core C-Research Computing, Bioinformatics, and Biostatistics), coordinate governance activities (executive committee and internal and external advisory committees), develop and implement education and mentoring programs, facilitate the pilot project program; and work to promote collaboration with other IDeA supported programs (COBRE, INBRE, and IDeA-CTR). The broad objectives of the Core A are to: (1) establish and maintain an effective organizational and governance structure to support state-of-the-art cores essential for MCHD investigators to apply cutting edge omics and computational approaches to address important scientific questions related to the health and disease continuum; (2) promote a research environment that is creative, nurturing, collaborative and multidisciplinary by providing education in omics and computational approaches, supportive mentoring and research funding for major project and pilot project investigators; (3) identify and implement long-term strategies to maximize sustainability of the MCHD by seeking quality improvement, implementation of new technology for research innovation, recruitment of new faculty, and fostering important interactions with other IDeA program. In total, these aims will work synergistically to develop an innovative, state-of-the-art Phase I COBRE to strengthen institutional infrastructure, provide a robust research training and mentoring environment for a diverse group of early career investigators with the common goal of developing a better understanding of molecular underpinnings of health and chronic disease.

核心A-摘要 健康与疾病分子中心（MCHD）是一个新的I期COBRE，其目标是促进 在分子生理学的中心主题下进行研究，以提高教育，指导和 培训研究人员，创造独特的机会，应用组学技术和计算生物学 在健康-疾病连续体中。虽然慢性病可以治疗，但对遗传学的理解 与疾病发作有关的易感性和分子机制有可能阻止疾病进展， 让一个人回到更健康的状态。基因组学、转录组学、蛋白质组学和 使用计算方法的具有生理信息的代谢组学数据集可以提供新的见解 进入与健康-疾病连续体相关的分子、细胞和整体生理学。关于MCHD 将由多个组成部分，包括一个行政单位，教育和指导计划， 试点项目计划，两个研究核心和三个主要项目调查员。特别是核心A- 行政、教育和指导将负责促进MCHD的使命， 促进使用创新方法来研究健康，疾病的发作和进展，以及相互作用 病原体，目的是了解从分子水平到整体的信息广度， 有机体核心A将提供行政支持，协调研究核心（包括核心B- 组学和基因编辑和核心C-研究计算，生物信息学和生物统计学），协调 治理活动（执行委员会和内部及外部咨询委员会）， 实施教育和指导计划，促进试点项目计划;并努力促进 与其他IDEA支持的计划（COBRE、INBRE和IDEA-CTR）合作。的广泛目标 核心A是：（1）建立和维持有效组织和治理结构， 最先进的核心是MCHD研究人员应用尖端组学和计算 解决与健康和疾病连续体有关的重要科学问题的方法;（2）促进 一个研究环境，是创造性的，培育，合作和多学科的教育， 组学和计算方法，支持性指导和重大项目和试点的研究资金 项目调查员;（3）确定和实施长期战略，以最大限度地提高MCHD的可持续性， 寻求质量改进，实施新技术研究创新，招聘新员工 教师，并促进与其他IDEA计划的重要互动。总之，这些目标将协同工作 开发一个创新的、最先进的COBRE第一阶段，以加强机构基础设施， 强大的研究培训和指导环境，为不同群体的早期职业调查人员提供 共同目标是更好地了解健康和慢性病的分子基础。