Core A- Administration, Education, and Mentoring

核心A--摘要 分子健康和疾病中心(MCHD)是一个新的第一阶段Cobre，其目标是促进 以分子生理学为中心主题的研究，以加强教育、指导和 培训研究人员以创造应用组学技术和计算生物学的独特机会 横跨健康-疾病连续体。虽然慢性病是可以治疗的，但对基因的理解 参与疾病发病的易感性和分子机制有可能阻止疾病的进展和 让一个人恢复到更健康的状态。基因组、转录组、蛋白质组和 使用计算方法的具有生理信息的代谢数据集可以提供新的洞察力 进入与健康-疾病连续体相关的分子、细胞和整体生理学。母婴健康中心 将由多个组成部分组成，包括行政单位、教育和指导计划、 试点项目计划、两个研究核心和三个重大项目调查人员。特别是，核心A- 行政、教育和辅导部门将负责促进母婴健康中心的使命 促进使用创新的方法来研究健康、疾病的发生和发展以及相互作用 对于病原体，目标是理解从分子水平到整体的信息广度 有机体。核心A将提供行政支持，协调研究核心的活动(包括核心B- 组学和基因编辑和核心C-研究计算、生物信息学和生物统计学)，协调 治理活动(执行委员会以及内部和外部咨询委员会)、发展和 实施教育和指导计划，促进试点项目计划；并努力促进 与其他IDEA支持计划(COBRE、INBRE和IDEA-CTR)合作。的广泛目标 核心A是：(1)建立和维持有效的组织和治理结构，以支持 MCHD研究人员应用尖端组学和计算必不可少的最先进核心 处理与健康和疾病连续体有关的重要科学问题的方法；(2)促进 通过在以下领域提供教育，创造、培养、协作和多学科的研究环境 组学和计算方法，重大项目和试点的支持性指导和研究资金 项目调查员；(3)确定和实施长期战略，通过以下方式最大限度地实现千年发展目标的可持续性 寻求质量改进，实施新技术进行研究创新，招募新的 教师，并促进与其他IDEA计划的重要互动。总的来说，这些目标将协同工作。 开发创新的、最先进的第一阶段Cobre以加强机构基础设施，提供 为不同的早期职业调查人员群体提供强大的研究培训和指导环境 共同目标是更好地了解健康和慢性病的分子基础。

Core A- Abstract The goal of the Molecular Center of Health and Disease (MCHD), a new Phase I COBRE, is to facilitate research under a central theme of molecular physiology to enhance the depth of education, mentorship, and training of researchers to generate unique opportunities to apply omics technology and computational biology across the health-disease continuum. While chronic diseases can be treated, an understanding of genetic susceptibility and molecular mechanisms involved in disease onset has the potential to halt progression and return an individual to a more healthy state. The integration of genomic, transcriptomic, proteomic, and metabolomic datasets with physiological information using computational approaches can provide novel insight into the molecular, cellular, and overall physiology associated with the health-disease continuum. The MCHD will be comprised of multiple components including an administrative unit, education and mentoring programs, a pilot project program, two research cores, and three major project investigators. In particular, Core A- Administration, Education, and Mentoring will be charged with promoting the mission of the MCHD to facilitate the use of innovative approaches to study health, onset and progression of disease, and interaction with pathogens, with the goal of understanding the breadth of information from the molecular level to the whole organism. Core A will provide administrative support, coordinate activities of research cores (including Core B- Omics and Gene-Editing and Core C-Research Computing, Bioinformatics, and Biostatistics), coordinate governance activities (executive committee and internal and external advisory committees), develop and implement education and mentoring programs, facilitate the pilot project program; and work to promote collaboration with other IDeA supported programs (COBRE, INBRE, and IDeA-CTR). The broad objectives of the Core A are to: (1) establish and maintain an effective organizational and governance structure to support state-of-the-art cores essential for MCHD investigators to apply cutting edge omics and computational approaches to address important scientific questions related to the health and disease continuum; (2) promote a research environment that is creative, nurturing, collaborative and multidisciplinary by providing education in omics and computational approaches, supportive mentoring and research funding for major project and pilot project investigators; (3) identify and implement long-term strategies to maximize sustainability of the MCHD by seeking quality improvement, implementation of new technology for research innovation, recruitment of new faculty, and fostering important interactions with other IDeA program. In total, these aims will work synergistically to develop an innovative, state-of-the-art Phase I COBRE to strengthen institutional infrastructure, provide a robust research training and mentoring environment for a diverse group of early career investigators with the common goal of developing a better understanding of molecular underpinnings of health and chronic disease.