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Neural control of breathing

呼吸的神经控制

基本信息

批准号：
10553260
负责人：
JACK L FELDMAN
金额：
$ 78.17万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-01-11 至 2023-12-31
项目状态：
已结题

项目摘要

PROJECT SUMMARY Breathing is a remarkable behavior fundamental to life that mediates gas exchange to support metabolism and regulate pH. A reliable, non-stop, robust rhythmic pattern of respiratory muscle activity is essential for breathing in mammals. Failure to maintain a normal breathing pattern in humans suffering from sleep apnea, apnea of prematurity, congenital central hypoventilation syndrome, hyperventilation syndrome, Rett syndrome, and perhaps Sudden Infant Death Syndrome, leads to serious adverse health consequences, even death. Various neurodegenerative diseases, such as Parkinson's disease, multiple systems atrophy, and amyotrophic lateral sclerosis, are associated with sleep disordered breathing that we hypothesize results from the loss of neurons in brain areas controlling respiration. If breathing is to be understood in normal and in pathological conditions, the mechanisms for respiratory central pattern generation must be revealed. We focus on two brain sites essential for generation of the normal breathing pattern, the preBötzinger Complex and the retrotrapezoid nucleus/parafacial respiratory group. We propose a broad series of experiments both in vivo and in vitro in rodents using advanced techniques including: viral delivery to express genetically encoded opsins or DREADDs in key subpopulations of neurons in these regions; advanced optical techniques to determine the contributions of the preBötzinger Complex microcircuit to rhythm generation; state-of-the-art neuroanatomical techniques to establish, in appropriate and necessary detail, the interconnectivity of the brainstem respiratory pattern generator. The data from these experiments will provide an extraordinary window into the mechanisms underlying respiratory rhythm and pattern generation.

项目总结

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons.

DOI：
10.3389/fnana.2020.00058
发表时间：
2020
期刊：
Frontiers in neuroanatomy
影响因子：
2.9
作者：
Yang CF;Kim EJ;Callaway EM;Feldman JL
通讯作者：
Feldman JL

Silent hypoxaemia in COVID-19 patients.

DOI：
10.1113/jp280769
发表时间：
2021-03
期刊：
The Journal of physiology
影响因子：
0
作者：
Simonson TS;Baker TL;Banzett RB;Bishop T;Dempsey JA;Feldman JL;Guyenet PG;Hodson EJ;Mitchell GS;Moya EA;Nokes BT;Orr JE;Owens RL;Poulin M;Rawling JM;Schmickl CN;Watters JJ;Younes M;Malhotra A
通讯作者：
Malhotra A

Distinct parafacial regions in control of breathing in adult rats.