RESPIRATORY CONTROL AND EMOTION REGULATION

呼吸控制和情绪调节

• 批准号: 10706592
• 负责人: JACK L FELDMAN
• 金额: $ 39万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2027-07-01
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706592
• 关键词: Ablation; Affect; Anxiety; Behavior; Behavioral; Birth; Blood gas; Brain; Brain Stem; Breathing; Carbon Dioxide; Clinic; Clinical; Data; Databases; Emotional; Emotional disorder; Emotions; Exposure to; Fright; Future; Genetic; Goals; Hippocampus; Human; Learning; Life; Lung; Maps; Measures; Mediating; Meditation; Mental Depression; Methods; Modeling; Moods; Mus; Muscle; Nervous System; Neural Pathways; Neuroanatomy; Neurons; Panic; Paper; Pathway interactions; Pattern; Physiological; Placebo Effect; Reaction; Research; Rodent; Rodent Model; Role; Signal Transduction; Site; Smell Perception; Stress; Structure; Synapses; Techniques; Testing; Vagus nerve structure; Visceral; Yoga; central pattern generator; design; detection platform; emotion regulation; experimental study; human disease; improved; locus ceruleus structure; negative emotional state; neural circuit; neuromechanism; neuroregulation; pain reduction; parabrachial nucleus; pranayama; preBotzinger complex; respiratory; response; sensory system; stress related disorder; therapy development; transmission process

Over the past few decades, research involving the neural control of breathing has centered on how the breathing rhythm is generated and how sensory systems detect internal and external changes to modulate the breathing pattern. While we have learned that the regulatory breathing rhythm originates in the medulla, we know little about the neural circuits by which breathing affects emotional state. The positive effects of controlled breathing on emotional state have been observed across many contexts and in the clinic. Using objective behavioral, physiological, and neuroanatomical parameters, we propose: i) to fully determine the neural pathways in mice from the preBötzinger Complex, the key site generating inspiratory rhythm in the medulla, to supramedullary regions, in particular to the locus coeruleus and its ascending projections, that effect and/or affect emotional state, and; ii) to establish the role of these projections from the preBötzinger Complex in mediating the effects of breathing on anxiety, fear and panic in mice. The proposed research has the potential to lead to more effective methods for treating debilitating negative emotional states

在过去的几十年里，涉及呼吸的神经控制的研究集中在如何