RESPIRATORY CONTROL AND EMOTION REGULATION

呼吸控制和情绪调节

• 批准号: 10706592
• 负责人: JACK L FELDMAN
• 金额: $ 39万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2027-07-01
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706592
• 关键词: Ablation; Affect; Anxiety; Behavior; Behavioral; Birth; Blood gas; Brain; Brain Stem; Breathing; Carbon Dioxide; Clinic; Clinical; Data; Databases; Emotional; Emotional disorder; Emotions; Exposure to; Fright; Future; Genetic; Goals; Hippocampus; Human; Learning; Life; Lung; Maps; Measures; Mediating; Meditation; Mental Depression; Methods; Modeling; Moods; Mus; Muscle; Nervous System; Neural Pathways; Neuroanatomy; Neurons; Panic; Paper; Pathway interactions; Pattern; Physiological; Placebo Effect; Reaction; Research; Rodent; Rodent Model; Role; Signal Transduction; Site; Smell Perception; Stress; Structure; Synapses; Techniques; Testing; Vagus nerve structure; Visceral; Yoga; central pattern generator; design; detection platform; emotion regulation; experimental study; human disease; improved; locus ceruleus structure; negative emotional state; neural circuit; neuromechanism; neuroregulation; pain reduction; parabrachial nucleus; pranayama; preBotzinger complex; respiratory; response; sensory system; stress related disorder; therapy development; transmission process

Over the past few decades, research involving the neural control of breathing has centered on how the breathing rhythm is generated and how sensory systems detect internal and external changes to modulate the breathing pattern. While we have learned that the regulatory breathing rhythm originates in the medulla, we know little about the neural circuits by which breathing affects emotional state. The positive effects of controlled breathing on emotional state have been observed across many contexts and in the clinic. Using objective behavioral, physiological, and neuroanatomical parameters, we propose: i) to fully determine the neural pathways in mice from the preBötzinger Complex, the key site generating inspiratory rhythm in the medulla, to supramedullary regions, in particular to the locus coeruleus and its ascending projections, that effect and/or affect emotional state, and; ii) to establish the role of these projections from the preBötzinger Complex in mediating the effects of breathing on anxiety, fear and panic in mice. The proposed research has the potential to lead to more effective methods for treating debilitating negative emotional states

在过去的几十年里，涉及呼吸的神经控制的研究一直集中在 呼吸节律是如何产生的，以及感觉系统如何检测内部和外部的变化来调节 呼吸模式。虽然我们已经了解到调节呼吸节律起源于延髓，但我们 对呼吸影响情绪状态的神经回路知之甚少。受控政策的积极作用 在许多情况下和临床上都观察到了情绪状态的呼吸。使用目标 行为、生理和神经解剖学参数，我们建议：i)充分确定神经 小鼠从Prebötzinger复合体到延髓中产生吸气节律的关键部位的通路 髓上区域，特别是蓝斑及其上升投射，这种效应和/或 影响情绪状态，以及；ii)确定这些来自Prebötzinger复合体的投射在 调节呼吸对小鼠焦虑、恐惧和惊恐的影响。拟议中的研究具有潜在的 找到更有效的方法来治疗令人衰弱的负面情绪