RESPIRATORY CONTROL AND EMOTION REGULATION
呼吸控制和情绪调节
基本信息
- 批准号:10676562
- 负责人:
- 金额:$ 39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-19 至 2027-07-01
- 项目状态:未结题
- 来源:
- 关键词:AffectAnxietyBehaviorBehavioralBirthBlood gasBrainBrain StemBreathingCarbon DioxideClinicClinicalDataDatabasesEmotionalEmotional disorderEmotionsExposure toFrightFutureGeneticGoalsHippocampus (Brain)HumanLeadLifeLungMapsMeasuresMediatingMeditationMental DepressionMethodsModelingMoodsMusMuscleNervous system structureNeural PathwaysNeuronsPanicPaperPathway interactionsPatternPhysiologicalPlacebo EffectReactionResearchRodentRodent ModelRoleSignal TransductionSiteSmell PerceptionStressStructureSynapsesTechniquesTestingVagus nerve structureVisceralVolitionYogacentral pattern generatordesignemotion regulationexperimental studyhuman diseaseimprovedlocus ceruleus structurenegative emotional stateneural circuitneuromechanismneuroregulationpain reductionparabrachial nucleuspranayamapreBotzinger complexrespiratoryresponsesensory systemstress related disordertherapy development
项目摘要
Over the past few decades, research involving the neural control of breathing has centered on how the
breathing rhythm is generated and how sensory systems detect internal and external changes to modulate the
breathing pattern. While we have learned that the regulatory breathing rhythm originates in the medulla, we
know little about the neural circuits by which breathing affects emotional state. The positive effects of controlled
breathing on emotional state have been observed across many contexts and in the clinic. Using objective
behavioral, physiological, and neuroanatomical parameters, we propose: i) to fully determine the neural
pathways in mice from the preBötzinger Complex, the key site generating inspiratory rhythm in the medulla, to
supramedullary regions, in particular to the locus coeruleus and its ascending projections, that effect and/or
affect emotional state, and; ii) to establish the role of these projections from the preBötzinger Complex in
mediating the effects of breathing on anxiety, fear and panic in mice. The proposed research has the potential
to lead to more effective methods for treating debilitating negative emotional states
在过去的几十年里,涉及呼吸的神经控制的研究集中在如何
项目成果
期刊论文数量(0)
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JACK L FELDMAN的其他文献
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{{ truncateString('JACK L FELDMAN', 18)}}的其他基金
Recruiting active expiration to overcome opioid-induced persistent apnea
招募主动呼气来克服阿片类药物引起的持续性呼吸暂停
- 批准号:
10656563 - 财政年份:2022
- 资助金额:
$ 39万 - 项目类别:
New brainstem targets for counteracting opioid induced apnea
对抗阿片类药物引起的呼吸暂停的新脑干目标
- 批准号:
10661014 - 财政年份:2022
- 资助金额:
$ 39万 - 项目类别:
Recruiting active expiration to overcome opioid-induced persistent apnea
招募主动呼气来克服阿片类药物引起的持续性呼吸暂停
- 批准号:
10512706 - 财政年份:2022
- 资助金额:
$ 39万 - 项目类别:
New brainstem targets for counteracting opioid induced apnea
对抗阿片类药物引起的呼吸暂停的新脑干目标
- 批准号:
10453339 - 财政年份:2022
- 资助金额:
$ 39万 - 项目类别:
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