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RESPIRATORY CONTROL AND EMOTION REGULATION

呼吸控制和情绪调节

基本信息

批准号：
10676562
负责人：
JACK L FELDMAN
金额：
$ 39万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-19 至 2027-07-01
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676562
关键词：
Affect Anxiety Behavior Behavioral Birth Blood gas Brain Brain Stem Breathing Carbon Dioxide Clinic Clinical Data Databases Emotional Emotional disorder Emotions Exposure to Fright Future Genetic Goals Hippocampus (Brain)Human Lead Life Lung Maps Measures Mediating Meditation Mental Depression Methods Modeling Moods Mus Muscle Nervous system structure Neural Pathways Neurons Panic Paper Pathway interactions Pattern Physiological Placebo Effect Reaction Research Rodent Rodent Model Role Signal Transduction Site Smell Perception Stress Structure Synapses Techniques Testing Vagus nerve structure Visceral Volition Yoga central pattern generator design emotion regulation experimental study human disease improved locus ceruleus structure negative emotional state neural circuit neuromechanism neuroregulation pain reduction parabrachial nucleus pranayama preBotzinger complex respiratory response sensory system stress related disorder therapy development

项目摘要

Over the past few decades, research involving the neural control of breathing has centered on how the breathing rhythm is generated and how sensory systems detect internal and external changes to modulate the breathing pattern. While we have learned that the regulatory breathing rhythm originates in the medulla, we know little about the neural circuits by which breathing affects emotional state. The positive effects of controlled breathing on emotional state have been observed across many contexts and in the clinic. Using objective behavioral, physiological, and neuroanatomical parameters, we propose: i) to fully determine the neural pathways in mice from the preBötzinger Complex, the key site generating inspiratory rhythm in the medulla, to supramedullary regions, in particular to the locus coeruleus and its ascending projections, that effect and/or affect emotional state, and; ii) to establish the role of these projections from the preBötzinger Complex in mediating the effects of breathing on anxiety, fear and panic in mice. The proposed research has the potential to lead to more effective methods for treating debilitating negative emotional states

在过去的几十年里，涉及呼吸的神经控制的研究集中在呼吸是如何发生的。呼吸节律的产生，以及感觉系统如何检测内部和外部变化，以调节呼吸模式虽然我们已经了解到调节性呼吸节律起源于延髓，但我们对呼吸影响情绪状态的神经回路知之甚少。控制的积极影响在许多情况下和临床中已经观察到情绪状态下的呼吸。使用客观行为，生理和神经解剖参数，我们建议：i）充分确定神经小鼠从前Bötzinger复合体（延髓中产生吸气节律的关键部位）到髓上区域，特别是蓝斑及其上行投射，影响和/或影响情绪状态，以及; ii）建立这些来自前Bötzinger复合体的投射在调节呼吸对小鼠焦虑、恐惧和恐慌的影响。这项研究有可能从而找到更有效的治疗消极情绪的方法