Shared Resource 06: Comparative Pathology and Digital Imaging (CPDISR)

共享资源 06：比较病理学和数字成像 (CPDISR)

• 批准号: 10553338
• 负责人: KRISTA MARIE DUBRAY LA PERLE
• 金额: $ 15.26万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-12 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553338
• 关键词: Abbreviations; Address; Age; Algorithms; Anatomy; Animal Model; Animals; Antibodies; Biological Markers; Biomedical Research; Biometry; Board Certification; Breeding; Budgets; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Hospital; Cancer Survivorship; Chemoprevention; Clinical Treatment; Clinical Trials; Comparative Pathology; Complement; Complex; Comprehensive Cancer Center; Computer software; Custom; Data Analyses; Development; Diagnostic; Engineering; Experimental Designs; Experimental Pathology; Flow Cytometry; Fostering; Funding; Genomics; Grant; Histology; Hour; Human; Human Pathology; IACUC; Image; Image Analysis; Immunofluorescence Immunologic; Immunohistochemistry; Immunologic Monitoring; Immunooncology; In Situ Hybridization; Informatics; Intervention; Intramural Research Program; Laboratories; Lesion; Machine Learning; Malignant Neoplasms; Medicine; Mentored Clinical Scientist Development Program; Microscopy; Minor; Molecular Carcinogenesis; Mus; NCI Center for Cancer Research; Names; Nutrient; Ohio; Pathologic; Pathologist; Pathology; Peer Review; Pharmaceutical Chemistry; Phenotype; Physiological; Phytochemical; Proteins; Proteomics; Publications; RNA; Research; Research Institute; Research Personnel; Resource Sharing; Sampling; Services; Slide; Stains; Surveys; Tissue Procurements; Tissues; Translational Research; Universities; Validation; Veterinary Medicine; Veterinary Pathology; Workload; animal imaging; animal tissue; biomedical informatics; cancer prevention; cancer therapy; carcinogenesis; clinical translation; college; comparative; digital imaging; experience; human tissue; improved; leukemia; leukemia tissue bank; meetings; member; open source; pathology imaging; pre-clinical; preclinical efficacy; preclinical toxicity; programs; quantitative imaging; recruit; tissue biomarkers; translational genomics; translational impact; translational study; translational therapeutics; treatment response; tumor progression

PROJECT SUMMARY – COMPARATIVE PATHOLOGY & DIGITAL IMAGING SHARED RESOURCE (CPDISR) The CPDISR provides expert, readily available and affordable experimental pathology support to investigators conducting research for understanding the development and treatment of cancer using preclinical animal models and/or human tissues procured for translational research. During the current funding period, a recent major development was the inclusion of complete histology services optimized for human tissues, as well as expanded slide digitization and quantitative image analysis services for stained human and animal tissue slides. As a result, Dr. Anil Parwani (MCC) has been named co-Director with Dr. Krista La Perle (CB), the name of the shared resource (SR) has been changed to the Comparative Pathology & Digital Imaging Shared Resource, and the Specific Aims have been modified accordingly. The Specific Aims are to: 1) provide consultative services to OSUCCC investigators for optimal experimental design, sample submission and data analysis, and interactions with other SRs; 2) provide support for preclinical efficacy and toxicity animal studies as well as translational studies that utilize human tissues; and 3) perform digitization and quantitative image analysis of stained slides from animal and human tissues. During the current 5-year grant cycle, a third board certified veterinary pathologist and seven additional technical staff have been added to anticipate usage in conjunction with the robust OSUCCC recruitment and strategic priorities. The CPDISR also acquired a Leica PELORIS 3 dual retort tissue processor after successful peer-reviewed funding through the OSUCCC Intramural Research Program. During this grant cycle, the CPDISR contributed to 84 publications (12 > 10 impact factor), 537 investigators, and 57 NCI grants, including 1 K12, 1 K22, 1 K24, 5 P01s, 1 P50, 35 R01s, 7 R21s, 2 R35s, 1 T32, and 3 U01s involving members of all five OSUCCC research programs. For the next grant cycle, the CPDISR will be a regular member of the Immune Monitoring and Discovery Platform, an overarching shared resource initiative fostering complex immuno-oncology projects. In addition, a major emphasis will be to continue to expand our available menu of antibodies optimized for immunohistochemistry, immunofluorescence and in situ hybridization in tissues of animal and human origin by various staining platforms, including multiplexing, according to the specific needs of OSUCCC members. We will also increase our support of image analysis projects allowing machine learning approaches to be developed with the center for cancer engineering; and continue to evaluate available open source and commercial image analysis software platforms/modules to complement our Aperio and Visiopharm software in order to quantify biomarkers in animal and human tissues. The annual budget of the CPDISR is $1,863,254, yet the CCSG request is $107,366. As such, the CPDIR seeks only 5.8% budgetary support from CCSG funds.

项目总结-比较病理学与数字影像共享资源（cpdisr）