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Comparative Pathology & Mouse Phenotyping

比较病理学

基本信息

批准号：
8567295
负责人：
KRISTA MARIE DUBRAY LA PERLE
金额：
$ 9.25万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8567295
关键词：
Accounting Address Age Anatomy Animal Cancer Model Animal Model Animals Antibodies Autopsy Biomedical Research Blood Breeding Businesses Cancer Center Support Grant Cancer Model Chemoprevention Clinical Clinical Chemistry Clinical Pathology Collection Communities Comparative Pathology Computer software Consultations Data Diagnostic radiologic examination Doctor of Philosophy Doctor of Veterinary Medicine Evaluation Experimental Designs Experimental Pathology Floor Freezing Funding Future Genetically Engineered Mouse Goals Head Hematology Histology Hour Housing Human Image Immunohistochemistry Individual Instruction Investigation Laboratories Laboratory Animals Lesion Light Microscope Link Liquid substance Location Malignant Neoplasms Medical Medicine Memorial Sloan-Kettering Cancer Center Microscopic Modeling Mus Names Neoplasm Metastasis Outcome Paraffin Paraffin Embedding Pathologic Pathologist Pathology Phenotype Photography Physiology Preparation Publications Recruitment Activity Research Research Personnel Resource Sharing Resources Rodent Safety Scientist Secure Services Site Slide Specimen Sq635 Staining method Stains Teaching Hospitals Telephone Testing Tissue Microarray Tissues Training and Education Treatment Efficacy United States National Institutes of Health Urinalysis Urine Veterinary Medicine Video Microscopy Work Xenograft procedure animal model development anticancer research college comparative design digital experience imaging modality improved member mouse model novel novel therapeutics programs sample collection skeletal tissue soft tissue therapy development tumor

项目摘要

The Comparative Pathology and Mouse Phenotyping Shared Resource (CPMPSR) provides expert, readily available and affordable experimental pathology support to investigators utilizing animal models to study human cancer. Formeriy known as the Mouse Phenotyping Shared Resource (established in 2001), it has been extensively reorganized since the recruitment in September 2008 of Krista La Perle, D.V.M., Ph.D., from Memorial Sloan Kettering Cancer Center. Dr. La Perie is a board-certified veterinary pathologist and NIH-funded, postdoctoral alumna of OSU's Department of Veterinary Biosciences (VBS). The shared resource name change reflects the diverse species of animals utilized in varied projects conducted by OSUCCC members that evaluate therapeutic efficacy, chemoprevention and safety of novel therapeutics in rodent and non-rodent xenograft and metastasis models, while continuing to emphasize the phenotypic characterization of newly generated genetically engineered mice. Under Dr. La Perie's direction and strong institutional support, the laboratory was relocated, technical support was expanded, and a second, dedicated comparative pathologist is being recruited. All of these improvements are designed to improve the quality of comparative pathology support provided to OSUCCC members and address concerns of the 2004 CCSG review. Continued services include comprehensive macroscopic and microscopic examinations of various species of laboratory animals, including genetically engineered mice. Clinical pathology testing including hematology, clinical chemistry and urinalyses performed previously by the OSU Veterinary Teaching Hospital Clinical Pathology Laboratory are now conducted in-house on newly acquired analyzers by a dedicated medical laboratory technologist. The CPMPSR also utilizes reference laboratories for novel tests not performed in-house. Radiography is performed by the CPMPSR to enhance morphologic evaluations on post-mortem specimens. The CPMPSR works closely on serial, ante-mortem imaging and pathology correlates with the OSUCCC Imaging Shared Resource to assist investigators who need the wide array of ante-mortem imaging modalities offered by the OSUCCC. Preparation of routine frozen and paraffin slides, tissue microarrays and special histochemical and immunohistochemical staining previously performed by the VBS Histology and Immunohistochemistry Core is now integrated with the CPMPSR. An extensive menu of immunohistochemical antibodies specifically for use on rodent tissues has been established. Tissue microarrays incorporating tumors from various mouse models of cancer have also been prepared. The CPMPSR provides a referral service to experienced scientists within the OSU research community providing expertise in animal model development, experimental design, optimal sample collection and data interpretation. The CPMPSR is utilized by all six OSUCCC Scientific Programs and OSUCCC members account for more than 60% of all users. The CPMPSR leverages extensive institutional support, and seeks only 25.6% support from CCSG funds. The service contributes critical support to high quality cancer relevant publications and the education and training of future cancer investigators.

比较病理学和小鼠表型共享资源（CPMPSR）为利用动物模型研究人类癌症的研究人员提供了专家、容易获得和负担得起的实验病理学支持。它的前身是小鼠表型共享资源（成立于2001年），自2008年9月招募Krista La Perle， D.V.M, Ph.D。