Cardiovascular Phenotyping Core B

心血管表型分析核心 B

• 批准号: 10555123
• 负责人: DAVID M POLLOCK
• 金额: $ 24.01万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555123
• 关键词: Aliquot; Ambulatory Blood Pressure Monitoring; Animal Model; Area; Blood Pressure; Blood Vessels; Blood specimen; Cardiovascular Physiology; Cardiovascular system; Cells; Chronic; Clinic; Computer software; Data; Data Analyses; Data Storage and Retrieval; Electronic Mail; Ensure; Frequencies; Goals; Guidelines; Health; Heart Rate; Hour; Human; Human Resources; Individual; Life; Measurement; Measures; Methods; Monitor; Motor Activity; Outcome; Participant; Pattern; Periodicity; Peripheral Blood Mononuclear Cell; Phase; Phenotype; Physicians; Physiologic pulse; Plasma; Play; Procedures; Quality Control; Reproducibility; Research Personnel; Resources; Rodent; Rodent Model; Role; Rural Community; Sampling; Scientist; Services; Statistical Data Interpretation; Stress; Structure; Supervision; Telemetry; Temperature; Time; Training; Validation; Work; biobank; blood pressure variability; cardiovascular disorder risk; cardiovascular risk factor; circadian; data acquisition; early life stress; experience; heart rate variability; human subject; in vivo; meetings; monocyte; multiple omics; peripheral blood; programs; remote location; resilience; synergism; ultrasound

CARDIOVASCULAR PHENOTYPING CORE B SUMMARY The primary goal and function of Core B is to provide services to the individual projects within the Program Project related to measures of cardiovascular function. The objective of Core B is to serve basic support services separated into three functional areas: 1) 24-hour blood pressure analysis in rodent models; 2) ambulatory and clinic blood pressure measurements and validation in human participants; and 3) pulse wave velocity and pulse wave analysis assessments in human subjects. We will also monitor quality control and reproducibility in cardiovascular measurements in both animal models and human subjects for maximum efficiency and rigor. Core B is structured to provide the highest degree of quality control and allow for consistency across all of the individual projects of the Program Project. This involves very closely coordinated efforts and sharing of expertise between the projects. Drs. David Pollock and Eric Judd will oversee Core B. Dr. Pollock has many years of experience coordinating large scale in vivo studies in rodents with over 20 years of conducting chronic blood pressure measurements by telemetry. Dr. Judd has directed a wide range of cardiovascular phenotyping studies in human subjects for over 10 years. This includes ambulatory blood pressure monitoring, vascular stiffness measurements via pulse wave velocity and pulse wave analysis. Core services will be tightly maintained with weekly contacts by email and monthly meetings to discuss how well Core B is functioning to meet the needs of the PPG and any issues that may have developed. The aims of Core B are: 1) Provide circadian analysis of 24-hour telemetry data in rodent models, 2) Provide frequency and time domain analysis for assessment of autonomic function in rodent models, 3) Provide supervision of clinic and ambulatory blood pressure measurements and consistent data acquisition and analysis, 4) Perform pulse wave velocity assessments, 5) Liaison with Core C to provide statistical analysis of cardiovascular data, and 6) Liaison with Core A to facilitate data storage.

心血管表型分析核心 B 总结 核心 B 的主要目标和功能是为计划内的各个项目提供服务 与心血管功能测量相关的项目。核心B的目标是提供基础支持 服务分为三个功能领域：1）啮齿动物模型的 24 小时血压分析； 2） 人类参与者的动态和临床血压测量和验证； 3) 脉搏波 对人体进行速度和脉搏波分析评估。我们还将监控质量控制和 动物模型和人类受试者的心血管测量的再现性最大化 效率和严谨。核心 B 的结构可提供最高程度的质量控制并允许 计划项目的所有单个项目的一致性。这涉及非常密切的协调 项目之间的努力和专业知识共享。博士。 David Pollock 和 Eric Judd 将监督 Core B。 Pollock 博士拥有 20 多年协调啮齿动物大规模体内研究的经验 通过遥测进行慢性血压测量。贾德博士指导了广泛的 对人类受试者的心血管表型研究已有 10 多年的历史。这包括动态血液 压力监测、通过脉搏波速度和脉搏波分析测量血管硬度。核 服务将得到严格维护，每周通过电子邮件进行联系，每月举行一次会议来讨论服务质量 核心 B 的作用是满足 PPG 的需求以及可能出现的任何问题。的目标 核心 B 是：1) 提供啮齿动物模型中 24 小时遥测数据的昼夜节律分析，2) 提供频率和 用于评估啮齿动物模型自主神经功能的时域分析，3) 提供临床监督 和动态血压测量以及一致的数据采集和分析，4) 执行脉搏测量 波速评估，5) 与 Core C 联络以提供心血管数据的统计分析，以及 6) 与Core A联络以方便数据存储。