Cardiovascular Phenotyping Core B

心血管表型核心B总结 核心B的主要目标和功能是为计划内的各个项目提供服务 与心血管功能测量相关的项目。核心B的目标是为基本保障服务 服务分为三个功能区：1)啮齿动物模型的24小时血压分析；2) 参与者的动态和临床血压测量和验证；以及3)脉搏波 受试者的速度和脉搏波分析评估。我们还将监测质量控制和 动物模型和人类受试者心血管测量的最大重复性 效率和严谨。核心B的结构旨在提供最高程度的质量控制，并允许 计划项目中所有单个项目的一致性。这涉及到非常密切的协调 项目之间的努力和专业知识的分享。大卫·波洛克博士和埃里克·贾德博士将负责监督核心B。 波洛克博士有超过20年协调大型啮齿动物体内研究的多年经验。 通过遥测进行慢性血压测量。贾德博士执导了一系列 人类受试者的心血管表型研究超过10年。这包括动态血液。 压力监测，通过脉搏波速度和脉搏波分析测量血管硬度。堆芯 将通过每周电子邮件联系和每月会议密切维护服务，讨论如何做好 核心B正在发挥作用，以满足PPG的需要和可能出现的任何问题。的目标是 核心B是：1)提供啮齿动物模型中24小时遥测数据的昼夜节律分析，2)提供频率和 时间域分析用于评估啮齿动物模型的自主神经功能，3)为临床提供指导 和动态血压测量以及一致的数据采集和分析，4)执行脉搏 波速评估，5)与核心C联络，以提供心血管数据的统计分析，以及6) 与核心A联络，以促进数据存储。

CARDIOVASCULAR PHENOTYPING CORE B SUMMARY The primary goal and function of Core B is to provide services to the individual projects within the Program Project related to measures of cardiovascular function. The objective of Core B is to serve basic support services separated into three functional areas: 1) 24-hour blood pressure analysis in rodent models; 2) ambulatory and clinic blood pressure measurements and validation in human participants; and 3) pulse wave velocity and pulse wave analysis assessments in human subjects. We will also monitor quality control and reproducibility in cardiovascular measurements in both animal models and human subjects for maximum efficiency and rigor. Core B is structured to provide the highest degree of quality control and allow for consistency across all of the individual projects of the Program Project. This involves very closely coordinated efforts and sharing of expertise between the projects. Drs. David Pollock and Eric Judd will oversee Core B. Dr. Pollock has many years of experience coordinating large scale in vivo studies in rodents with over 20 years of conducting chronic blood pressure measurements by telemetry. Dr. Judd has directed a wide range of cardiovascular phenotyping studies in human subjects for over 10 years. This includes ambulatory blood pressure monitoring, vascular stiffness measurements via pulse wave velocity and pulse wave analysis. Core services will be tightly maintained with weekly contacts by email and monthly meetings to discuss how well Core B is functioning to meet the needs of the PPG and any issues that may have developed. The aims of Core B are: 1) Provide circadian analysis of 24-hour telemetry data in rodent models, 2) Provide frequency and time domain analysis for assessment of autonomic function in rodent models, 3) Provide supervision of clinic and ambulatory blood pressure measurements and consistent data acquisition and analysis, 4) Perform pulse wave velocity assessments, 5) Liaison with Core C to provide statistical analysis of cardiovascular data, and 6) Liaison with Core A to facilitate data storage.