Cardiovascular Phenotyping Core B

心血管表型分析核心 B

• 批准号: 10555123
• 负责人: DAVID M POLLOCK
• 金额: $ 24.01万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555123
• 关键词: Aliquot; Ambulatory Blood Pressure Monitoring; Animal Model; Area; Blood Pressure; Blood Vessels; Blood specimen; Cardiovascular Physiology; Cardiovascular system; Cells; Chronic; Clinic; Computer software; Data; Data Analyses; Data Storage and Retrieval; Electronic Mail; Ensure; Frequencies; Goals; Guidelines; Health; Heart Rate; Hour; Human; Human Resources; Individual; Life; Measurement; Measures; Methods; Monitor; Motor Activity; Outcome; Participant; Pattern; Periodicity; Peripheral Blood Mononuclear Cell; Phase; Phenotype; Physicians; Physiologic pulse; Plasma; Play; Procedures; Quality Control; Reproducibility; Research Personnel; Resources; Rodent; Rodent Model; Role; Rural Community; Sampling; Scientist; Services; Statistical Data Interpretation; Stress; Structure; Supervision; Telemetry; Temperature; Time; Training; Validation; Work; biobank; blood pressure variability; cardiovascular disorder risk; cardiovascular risk factor; circadian; data acquisition; early life stress; experience; heart rate variability; human subject; in vivo; meetings; monocyte; multiple omics; peripheral blood; programs; remote location; resilience; synergism; ultrasound

CARDIOVASCULAR PHENOTYPING CORE B SUMMARY The primary goal and function of Core B is to provide services to the individual projects within the Program Project related to measures of cardiovascular function. The objective of Core B is to serve basic support services separated into three functional areas: 1) 24-hour blood pressure analysis in rodent models; 2) ambulatory and clinic blood pressure measurements and validation in human participants; and 3) pulse wave velocity and pulse wave analysis assessments in human subjects. We will also monitor quality control and reproducibility in cardiovascular measurements in both animal models and human subjects for maximum efficiency and rigor. Core B is structured to provide the highest degree of quality control and allow for consistency across all of the individual projects of the Program Project. This involves very closely coordinated efforts and sharing of expertise between the projects. Drs. David Pollock and Eric Judd will oversee Core B. Dr. Pollock has many years of experience coordinating large scale in vivo studies in rodents with over 20 years of conducting chronic blood pressure measurements by telemetry. Dr. Judd has directed a wide range of cardiovascular phenotyping studies in human subjects for over 10 years. This includes ambulatory blood pressure monitoring, vascular stiffness measurements via pulse wave velocity and pulse wave analysis. Core services will be tightly maintained with weekly contacts by email and monthly meetings to discuss how well Core B is functioning to meet the needs of the PPG and any issues that may have developed. The aims of Core B are: 1) Provide circadian analysis of 24-hour telemetry data in rodent models, 2) Provide frequency and time domain analysis for assessment of autonomic function in rodent models, 3) Provide supervision of clinic and ambulatory blood pressure measurements and consistent data acquisition and analysis, 4) Perform pulse wave velocity assessments, 5) Liaison with Core C to provide statistical analysis of cardiovascular data, and 6) Liaison with Core A to facilitate data storage.

心血管表型核心B总结 核心B的主要目标和功能是为项目内的各个项目提供服务 心血管功能测量相关项目。核心B的目标是提供基本支助 服务分为三个功能领域：1）啮齿动物模型的24小时血压分析; 2） 在人类参与者中的动态和诊所血压测量和验证;以及3）脉搏波 速度和脉搏波分析评估。我们还将监督质量控制， 在动物模型和人类受试者中的心血管测量的再现性， 效率和严谨。核心B的结构是为了提供最高程度的质量控制，并允许 在项目的所有单个项目中保持一致性。这涉及到非常密切的协调 项目之间的合作和专业知识的共享。大卫波洛克博士和埃里克贾德将监督核心B。 博士Pollock在协调啮齿类动物的大规模体内研究方面拥有多年经验， 通过遥测进行慢性血压测量。贾德博士指导了一系列 在人类受试者中进行的心血管表型研究超过10年。这包括流动血液 压力监测、通过脉搏波速度和脉搏波分析的血管硬度测量。核心 将通过每周电子邮件联系和每月会议来密切维护服务， 核心B正在发挥作用，以满足PPG的需求和可能出现的任何问题。的目的 核心B是：1）提供啮齿动物模型中24小时遥测数据的昼夜节律分析，2）提供频率和 时域分析用于评估啮齿动物模型中的自主功能，3）提供临床监督 和动态血压测量和一致的数据采集和分析，4）进行脉搏测量， 波速度评估，5）与核心C联络，以提供心血管数据的统计分析，以及6） 与核心A联络，以促进数据存储。