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Emerging Technologies for Early Detection of Distal Leg Stress Fracture.

早期检测腿部远端应力性骨折的新兴技术。

基本信息

批准号：
10557619
负责人：
Tyler Brown
金额：
$ 20.33万
依托单位：
BOISE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-06 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10557619
关键词：
Affect Athletic Biomechanics Bone Matrix Communities Computational algorithm Cumulative Trauma Disorders Data Detection Development Diagnosis Distal Early Diagnosis Early identification Economics Emerging Technologies Engineering Etiology Evaluation Foundations Fracture Goals Health Image Incidence Individual Injury Jogging Joints Knowledge Lead Leg Lower Extremity Measures Mental Health Military Personnel Modality Modeling Motor Activity Outcome Pain Participant Patients Personal Satisfaction Physical activity Prevalence Prevention Principal Component Analysis Recording of previous events Recovery Recreation Rehabilitation therapy Reporting Research Research Personnel Rest Risk Robotics Running Rupture Science Severities Speed Splint Device Standardization Statistical Models Stress Fractures Surface Symptoms System Techniques Technology Testing Tibial Fractures Time Torsion Transducers Ultrasonography Vision Walking Work accurate diagnosis bone career diagnostic platform electronic sensor experience flexible electronics fracture risk high risk population improved injured injury prevention innovation long bone longitudinal analysis mechanical load musculoskeletal injury physical conditioning portability radiological imaging radiologist real time monitoring repaired stress reduction tibia ultrasound

项目摘要

PROJECT SUMMARY – BROWN Stress Fracture is a common and highly destructive overuse musculoskeletal injury that may be successfully treated with a brief reduction in physical activity. Yet, we currently lack the scientific knowledge and technical capacity to accurately assess bone damage in time to allow practitioners an opportunity to prescribe the rest necessary to avoid fracture development. The long-term goal is to enhance scientific knowledge of stress fracture development, and improve researcher and clinician ability to predict and accurately detect individuals at risk for stress fracture. The project hypothesis in this application is practitioners can diagnose stress fracture risk prior to injury by detecting abnormal tibial loading and bone microdamage before injury development. The rationale for this work is that enabling early and accurate diagnosis of tibial stress fracture may be key for efficacious prevention and treatment modalities, and a substantial reduction in the incidence of this destructive musculoskeletal injury. The project hypothesis will be tested by pursuing three specific aims: (1) Quantify tibial bone loads across a range of physical activities; (2) Develop statistical model of tibial loading during physical activity; and (3) Automate ultrasound use to detect tibial stress fracture. For the first and second aims, we will collect biomechanical data to evaluate tibial loading during conditions commonly encountered during outdoor physical activity for individuals with and without history of tibial stress fracture, and mechanically load a tibia to develop a statistical model of bone loading experienced during single and repeated bouts of physical activity. For the third aim, we will collect ultrasound images of a tibia shortly after stress fracture and after fracture symptoms have subsided to standardize image acquisition and analysis techniques to automate detection of injury. The proposed research is innovative, in the applicant’s opinion, because it seeks to expand foundational knowledge regarding tibial stress fracture development that can be implemented to facilitate accurate identification of individuals at risk for stress fracture and enable early detection of the tibial damage that is a precursor to injury. The proposed research is significant because it will provide the wider scientific community the valuable knowledge to immediately improve tibial stress fracture diagnosis and treatment, as well as a strong scientific foundation to develop effective prevention and rehabilitative strategies for this common musculoskeletal injury. Collectively, these tangible benefits have potential to substantially reduce the prevalence of this common overuse injury.

项目总结-棕色