Nutrition and Superfund Chemical Toxicity

营养和超级基金化学毒性

• 批准号: 10596279
• 负责人: Kelly G Pennell
• 金额: $ 137.52万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-07 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596279
• 关键词: Acceleration; Address; Aging; Appalachian Region; Awareness; Binding; Biochemical; Biological; Biological Markers; Biological Models; Biological Monitoring; Biomedical Research; Biomimetics; Chemicals; Communication; Communities; Complex; Consumption; Data; Data Analyses; Diet; Diffusion; Disease; Disease Outcome; Economically Deprived Population; Engineering; Environment; Environmental Engineering technology; Environmental Health; Environmental Pollutants; Environmental Science; Evaluation; Exercise; Exposure to; Fiber; Fostering; Funding; Future; Goals; Hazardous Substances; Health; Human; Industry; Intake; Interdisciplinary Study; Intervention; Iron; Kentucky; Life; Life Style; Link; Membrane; Metabolic; Metals; Methods; Molecular; Nanostructures; National Institute of Environmental Health Sciences; Nutrient; Outcome; Oxides; Pathway interactions; Physical activity; Physiological; Plants; Policy Maker; Polychlorinated Biphenyls; Predisposition; Pregnancy; Prevention; Prevention strategy; Primary Prevention; Problem Sets; Recommendation; Research; Research Project Grants; Resources; Risk; Risk Assessment; Risk Management; Science; Scientist; Services; Site; Social isolation; Superfund; System; Techniques; Technology; Tetrachloroethylene; Toxic effect; Toxicant exposure; Training; Translational Research; Trichloroethylene; Universities; Vulnerable Populations; chemical stability; chronic inflammatory disease; community engaged research; community engagement; community intervention; community involvement; data management; detection method; dietary; disorder prevention; disorder risk; environmental chemical; environmental chemistry; experience; exposure pathway; graphene; halogenation; healthy lifestyle; human old age (65+); improved; innovation; insight; interdisciplinary approach; lifestyle intervention; lipidomics; metabolomics; next generation; novel; nutrition; organic contaminant; policy recommendation; pollutant; polyphenol; prevent; programs; remediation; superfund chemical; superfund site; tool; vulnerable community

PROJECT SUMMARY The University of Kentucky Superfund Research Center (UK-SRC) provides a focused, cross-disciplinary research and training environment to address critical human health challenges associated with halogenated organic substance exposures. Four center projects and five cores make up the proposed UK-SRC to further develop research on lifestyle changes (e.g., nutrition and exercise) in addition to two environmental science projects that will focus on the remediation and engineering solutions to this set of problems. Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) and trichloroethylene (TCE) pose significant health risks and enduring remediation challenges, including sites such as the Paducah Gaseous Diffusion Plant, the largest Superfund site in Kentucky. The UK-SRC’s overall focus for this next cycle is the human health impacts of persistent halogenated organics (e.g., PCBs, TCE, and tetrachloroethene (PCE), and in this new cycle of funding, additional questions about per- and polyfluoralkyl substances (PFAS) will be incorporated. Projects covering biomedical research hypothesize that healthy nutrition and exercise components provide a platform to develop primary prevention strategies for diseases associated with environmental toxic insults, while also providing the basis for new risk assessment paradigms. Further, novel iron-based, nano-structured sensing, capture and remediation systems based on biomimetic binding domains and functionalized membrane platforms offer potential for sustainable advances in technical capability for site remediation. The UK-SRC proposes the following goals: 1) to expedite data-driven discovery as facilitated by the Data Management and Analysis Core that will provide insight about biomarkers of exposures to generate new information about the relationship between pollutant exposure, nutrient intake, physical activity and disease risk; 2) to better understand the biochemical, molecular, and cellular mechanisms underlying the toxicity of halogenated organic compounds (i.e., PCBs and PFAS) with a specific focus on chronic inflammatory diseases and windows of susceptibility; 3) to foster informed decisions that expedite clean-up of halogenated organic compounds through advanced material-based technologies, smart filters, and fate and transport science to reduce exposure risks; 4) to promote and interdisciplinary approaches to environmental health science training that accelerate the impact of complex solution-oriented, stakeholder-engaged research aimed at reducing exposures and improving human health; and 5) to engage bi-directionally and provide environmental health programmatic activities to vulnerable, socially-isolated, under-resourced communities in Kentucky, especially Eastern Kentucky (i.e. Central Appalachia), where chronic inflammatory diseases exceed national averages and exposure risks to environmental pollutants are prevalent. Activities will involve community engaged research and an innovative means of integrating projects through the WHY-ENVIRONMENT initiative.

项目摘要 肯塔基州大学超级基金研究中心（UK-SRC）提供了一个集中的，跨学科的 研究和培训环境，以应对与卤化 有机物质暴露。四个中心项目和五个核心组成了拟议的UK-SRC， 开展关于生活方式改变的研究（例如，营养和运动），以及两个环境科学 这些项目将侧重于这一系列问题的补救和工程解决方案。由于其 相对化学稳定性和普遍存在于环境中，氯化有机污染物， 多氯联苯（PCBs）和三氯乙烯（TCE）对健康构成重大风险， 补救的挑战，包括网站，如帕迪尤卡气体扩散厂，最大的超级基金 位于肯塔基州。UK-SRC下一个周期的总体重点是持续性的人类健康影响。 卤化有机物（例如，多氯联苯、三氯乙烯和四氯乙烯，在这一新的供资周期中， 将纳入关于全氟烷基和多氟烷基物质的其他问题。项目涵盖 生物医学研究假设，健康的营养和锻炼成分提供了一个平台， 与环境毒性损伤有关的疾病的初级预防战略，同时还提供 新的风险评估模式的基础。此外，新型铁基纳米结构的传感、捕获和 基于仿生结合域和功能化膜平台的修复系统提供了 在场地补救技术能力方面的可持续发展潜力。英国SRC建议， 以下目标：1）在数据管理和分析核心的帮助下加快数据驱动的发现 这将提供有关暴露的生物标志物的见解，以产生有关这种关系的新信息， 污染物暴露、营养摄入、身体活动和疾病风险之间的关系; 2）更好地了解 卤代有机化合物毒性的生化、分子和细胞机制 (i.e.,多氯联苯和PFAS），特别关注慢性炎症性疾病和易感性窗口; 3） 促进知情决策，通过先进的技术， 基于材料的技术、智能过滤器以及归宿和迁移科学，以减少接触风险; 4） 促进环境卫生科学培训的跨学科方法，加速 复杂的解决方案为导向的，企业参与的研究，旨在减少暴露和改善人类 5）双向参与并提供环境健康方案活动， 肯塔基州，特别是肯塔基州东部（即肯塔基州东部）的脆弱、社会孤立、资源不足的社区。 中阿巴拉契亚），慢性炎症性疾病超过全国平均水平， 环境污染物普遍存在。活动将涉及社区参与的研究和创新的 通过“为什么-环境”倡议整合项目的手段。