KC Donnelly Externship Admin Supplement for Victoria Klaus P42ES007380 UKSRC

KC Donnelly for维多利亚Klaus P42 ES 007380 - 25 PD/PI：Kelly Pennell KCD项目描述（摘要）： 我目前在UKSRC项目3中的研究是合成具有亲和力的先进吸附剂材料 对于PFAS。目前正在研究这些材料从水溶液中去除PFAS的能力。 系统，但我们计划评估其作为肠道吸附剂的有效性，以消除这些污染物从 人体PFAS与一系列不良健康影响有关， PFAS暴露的常见途径是通过受污染的饮用水。因此，去除这些 需要去除来自饮用水和人体的污染物。肠吸附剂口服 施用的吸附剂通过胃肠道，在胃肠道中它们结合各种物质， 在排泄之前干扰体内的其他系统。重要的是，肠吸附剂已经被 被证明是一种有前途的，非侵入性的治疗方法，用于急性和慢性的影响， 化学污染物暴露。与TAMUSRC项目5及其已建立的生物测定一起 技术和生态毒理学分析，我们将分析先进的吸附剂材料开发， UKSRC在TAMUSRC处理水中的PFAS，以确定其安全性和有效性， 肠吸附剂。我们在UKSRC项目3中开发的先进吸附剂将进行筛选， 在英国的初步水性研究中，对PFAS表现出最高亲和力的那些。这些将是 使用分析技术和生物测定方法分析其肠吸附剂应用， TAMUSRC项目5的一部分。

KC Donnelly for Victoria Klaus P42ES007380‐25 PD/PI: Kelly Pennell KCD Project Description (abstract): My current research within UKSRC Project 3 is to synthesize advanced sorbent materials with an affinity for PFAS. These materials are currently being studied for their ability to remove PFAS from aqueous systems, but we plan to assess their efficacy as enterosorbents to remove these contaminants from the human body. PFAS have been connected to a series of adverse health effects, and one of the most common routes of PFAS exposure is through contaminated drinking water. Thus, the removal of these contaminants from both drinking water and the human body is needed. Enterosorbents are orally administered sorbents that pass through the GI tract where they bind various substances without disturbing other systems within the body prior to excretion. Importantly, enterosorbents have been shown to be a promising, non‐invasive therapeutic treatment approach for acute and chronic impacts of chemical contaminant exposures. Together with TAMUSRC Project 5 and their established bioassay techniques and ecotoxicological analyses, we will analyze advanced sorbent materials developed at UKSRC for treatment of PFAS in water at TAMUSRC to determine their safety and efficacy as enterosorbents. Our advanced sorbents developed within UKSRC Project 3 will be screened to identify those that exhibit the highest affinity for PFAS in preliminary aqueous studies at UK. These will be analyzed for their enterosorbents applications using analytical technologies and bioassay methods as part of TAMUSRC Project 5.