KC Donnelly Externship Admin Supplement for Victoria Klaus P42ES007380 UKSRC

KC Donnelly 维多利亚·克劳斯 (Victoria Klaus) 实习管理补充资料 P42ES007380 UKSRC

• 批准号: 10795313
• 负责人: Kelly G Pennell
• 金额: $ 1.45万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-10 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10795313
• 关键词: Acute; Affinity; Binding; Biological Assay; Chemicals; Chronic; Collaborations; Drug Metabolic Detoxication; Ensure; Excision; Excretory function; Exhibits; Exposure to; Gastrointestinal tract structure; Health; Human body; Hydrogels; Individual; Learning; Methodology; Methods; Oral Administration; Organism; Poly-fluoroalkyl substances; Polymers; Postdoctoral Fellow; Research; Research Project Grants; Review Literature; Route; Safety; Series; System; Techniques; Technology; Texas; Therapeutic; Toxic effect; Universities; Water; aqueous; contaminated drinking water; drinking water; experience; experimental study; externship; novel

KC Donnelly for Victoria Klaus P42ES007380‐25 PD/PI: Kelly Pennell KCD Project Description (abstract): My current research within UKSRC Project 3 is to synthesize advanced sorbent materials with an affinity for PFAS. These materials are currently being studied for their ability to remove PFAS from aqueous systems, but we plan to assess their efficacy as enterosorbents to remove these contaminants from the human body. PFAS have been connected to a series of adverse health effects, and one of the most common routes of PFAS exposure is through contaminated drinking water. Thus, the removal of these contaminants from both drinking water and the human body is needed. Enterosorbents are orally administered sorbents that pass through the GI tract where they bind various substances without disturbing other systems within the body prior to excretion. Importantly, enterosorbents have been shown to be a promising, non‐invasive therapeutic treatment approach for acute and chronic impacts of chemical contaminant exposures. Together with TAMUSRC Project 5 and their established bioassay techniques and ecotoxicological analyses, we will analyze advanced sorbent materials developed at UKSRC for treatment of PFAS in water at TAMUSRC to determine their safety and efficacy as enterosorbents. Our advanced sorbents developed within UKSRC Project 3 will be screened to identify those that exhibit the highest affinity for PFAS in preliminary aqueous studies at UK. These will be analyzed for their enterosorbents applications using analytical technologies and bioassay methods as part of TAMUSRC Project 5.

KC Donnelly for Victoria Klaus P42ES007380-25 PD/PI：Kelly Pennell 九龙文化区项目简介(摘要)： 我目前在UKSRC项目3中的研究是合成具有亲和力的先进吸附材料 对于全氟辛烷磺酸。这些材料目前正在研究其去除水中全氟辛烷磺酸的能力。 系统，但我们计划评估它们作为肠道吸附剂的有效性，以从 人体。全氟辛烷磺酸与一系列不利的健康影响有关，而且是最严重的 接触全氟辛烷磺酸的常见途径是通过受污染的饮用水。因此，删除这些 需要来自饮用水和人体的污染物。肠道吸附剂是口服的 使用吸着剂穿过胃肠道，在那里它们结合各种物质，而不是 排泄前扰乱体内其他系统的。重要的是，肠吸附剂已经 被证明是一种有前途的、非侵入性的治疗方法，可治疗急性和慢性影响 接触化学污染物。与TAMUSRC项目5和他们建立的生物检测一起 技术和生态毒理分析，我们将分析开发的先进吸附材料 UKSRC在TAMUSRC处理水中全氟辛烷磺酸的安全性和有效性 肠吸附剂。我们在UKSRC Project 3中开发的高级吸着剂将进行筛选，以确定 在英国的初步水研究中显示出对全氟辛烷磺酸亲和力最高的产品。这些将是 使用分析技术和生物测定方法对其肠道吸附应用进行分析 TAMUSRC项目5的一部分。

项目成果

Community Forum Identifies Opportunities to Engage with Eastern Kentucky Community Leaders about Chronic Disease and Environmental Pollution.

• DOI: 10.1080/1533015x.2019.1597660
• 发表时间: 2020
• 期刊: Applied environmental education and communication (Print)
• 作者: Brewer D;Travis E;Koempel A;Ormsbee L;Pennell K
• 通讯作者: Pennell K

Single step synthesis, characterization and applications of curcumin functionalized iron oxide magnetic nanoparticles.

• DOI: 10.1016/j.msec.2016.04.093
• 发表时间: 2016-10-01
• 期刊: Materials science & engineering. C, Materials for biological applications
• 作者: Bhandari R;Gupta P;Dziubla T;Hilt JZ
• 通讯作者: Hilt JZ

Invited Perspective: Making the Implicit Explicit-Connecting Environmental Health Literacy and Exposure Report-Back.

• DOI: 10.1289/ehp13493
• 发表时间: 2023-09
• 期刊: Environmental health perspectives
• 影响因子: 10.4

Layer-by-layer Assembled Membranes with Immobilized Porins.

逐层组装的膜，带有固定的孔蛋白。

• DOI: 10.1039/c7ra08737c
• 发表时间: 2017
• 期刊: RSC advances
• 影响因子: 3.9
• 作者: Hernández S;Porter C;Zhang X;Wei Y;Bhattacharyya D
• 通讯作者: Bhattacharyya D

Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis.

多氯联苯77诱导脂肪细胞分化和促炎脂肪因子，并促进肥胖和动脉粥样硬化。

• DOI: 10.1289/ehp.10554
• 发表时间: 2008-06
• 期刊: ENVIRONMENTAL HEALTH PERSPECTIVES
• 影响因子: 10.4
• 作者: Arsenescu, Violeta;Arsenescu, Razvan I.;King, Victoria;Swanson, Hollie;Cassis, Lisa A.
• 通讯作者: Cassis, Lisa A.