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NUTRITION AND SUPERFUND CHEMICAL TOXICITY

营养和超级化学毒性

基本信息

批准号：
10263610
负责人：
Kelly G Pennell
金额：
$ 19.88万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-07 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10263610
关键词：
Address Age Aging Appalachian Region Awareness Binding Biochemical Biological Biological Markers Biological Models Biological Monitoring Biomedical Engineering Biomedical Research Biomimetics Chemicals Communication Research Communities Complex Consumption Data Data Analyses Detection Diet Diet and Nutrition Diffusion Disease Disease Outcome Ecology Economically Deprived Population Engineering Environment Environmental Engineering technology Environmental Health Environmental Pollutants Environmental Pollution Evaluation Exercise Exposure to Fiber Fostering Funding Future Goals Hazardous Substances Health Human Industry Intake Interdisciplinary Study Intervention Iron Kentucky Life Life Style Link Membrane Metals Methods Molecular Nanostructures National Institute of Environmental Health Sciences Nutrient Outcome Oxides Pathway interactions Physical activity Physiological Plants Policies Policy Maker Polychlorinated Biphenyls Predisposition Pregnancy Prevention Prevention strategy Primary Prevention Problem Sets Recommendation Research Research Project Grants Research Training Resources Risk Risk Assessment Risk Management Science Scientist Services Site Superfund System Techniques Technology Tetrachloroethylene Toxic effect Toxicant exposure Training Translational Research Trichloroethylene Universities Vulnerable Populations base chemical stability chronic inflammatory disease community intervention community involvement data management disadvantaged population disorder prevention disorder risk environmental chemical environmental chemistry experience exposure pathway graphene healthy lifestyle improved innovation insight interdisciplinary approach lifestyle intervention metabolic profile metabolomics next generation novel nutrition organic contaminant pollutant polyphenol prevent programs remediation social superfund chemical superfund site tool

项目摘要

PROJECT SUMMARY The University of Kentucky Superfund Research Center (UK-SRC) provides a focused, cross-disciplinary research and training environment to address critical human health challenges associated with halogenated organic substance exposures. Four center projects and five cores make up the proposed UK-SRC to further develop research on lifestyle changes (e.g., nutrition and exercise) in addition to two environmental science projects that will focus on the remediation and engineering solutions to this set of problems. Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) and trichloroethylene (TCE) pose significant health risks and enduring remediation challenges, including sites such as the Paducah Gaseous Diffusion Plant, the largest Superfund site in Kentucky. The UK-SRC’s overall focus for this next cycle is the human health impacts of persistent halogenated organics (e.g., PCBs, TCE, and tetrachloroethene (PCE), and in this new cycle of funding, additional questions about per- and polyfluoralkyl substances (PFAS) will be incorporated. Projects covering biomedical research hypothesize that healthy nutrition and exercise components provide a platform to develop primary prevention strategies for diseases associated with environmental toxic insults, while also providing the basis for new risk assessment paradigms. Further, novel iron-based, nano-structured sensing, capture and remediation systems based on biomimetic binding domains and functionalized membrane platforms offer potential for sustainable advances in technical capability for site remediation. The UK-SRC proposes the following goals: 1) to expedite data-driven discovery as facilitated by the Data Management and Analysis Core that will provide insight about biomarkers of exposures to generate new information about the relationship between pollutant exposure, nutrient intake, physical activity and disease risk; 2) to better understand the biochemical, molecular, and cellular mechanisms underlying the toxicity of halogenated organic compounds (i.e., PCBs and PFAS) with a specific focus on chronic inflammatory diseases and windows of susceptibility; 3) to foster informed decisions that expedite clean-up of halogenated organic compounds through advanced material-based technologies, smart filters, and fate and transport science to reduce exposure risks; 4) to promote and interdisciplinary approaches to environmental health science training that accelerate the impact of complex solution-oriented, stakeholder-engaged research aimed at reducing exposures and improving human health; and 5) to engage bi-directionally and provide environmental health programmatic activities to vulnerable, socially-isolated, under-resourced communities in Kentucky, especially Eastern Kentucky (i.e. Central Appalachia), where chronic inflammatory diseases exceed national averages and exposure risks to environmental pollutants are prevalent. Activities will involve community engaged research and an innovative means of integrating projects through the WHY-ENVIRONMENT initiative.

项目总结