MOLLUSCAN FAUNAS AND ASIAN SCHISTOSOMIASIS

软体动物与亚洲血吸虫病

• 批准号: 2059789
• 负责人: GEORGE M DAVIS
• 金额: $ 14.79万
• 依托单位: THE ACADEMY OF NATURAL SCIENCES OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1996-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2059789
• 关键词: Asia; China; Gastropoda; India; Schistosoma; animal ecology; animal population genetics; biochemical evolution; communicable disease transmission; epizootiology; histology; host organism interaction; nucleic acid hybridization; nucleic acid sequence; polymerase chain reaction; scanning electron microscopy; schistosomiasis; southeast Asia; species difference; statistics /biometry; systematic biology

Schistosomiasis continues to be one of the leading public health problems in Asia. Until 1980, schistosomiasis in Asia was attributed in the medical literature to Schistosoma japonicum transmitted by the snail genus Oncomelania. Today, as a result of this NIH sponsored research, it is recognized that there is a S. japonicum species complex transmitted by a number of snail species of two diverging snail lineages. The snail species - Schistosoma sp. associations are phylogenetically constrained. This proposal continues to focus on uncovering the diversity of snails transmitting Schistosoma in Asia, with current emphasis in China. The objectives are 1) to continue detailed comparative anatomical studies of Pomatiopsidae: Triculinae snails throughout Southern China to establish clear definitions of genera and species, and to incorporate the new data into the phylogeny of the Pomatiopsidae thereby testing that phylogeny with each new addition. The snail-species-Schistosoma sp. interactions are mapped on the phylogeny to assess pattern and process of taxon- specific evolution and coevolution; 2) to continue molecular genetic studies of Triculinae taxa and populations of Oncomelania in laboratories established under this program in China. Molecular data are used to test the congruence of anatomy-based phylogeny with molecular-based phylogeny, and the pattern of snail genetics as it related to Schistosoma transmission; 3) to continue DNA sequence work in Philadelphia for phylogenetic assessment of the Pomatiopsidae. Work is in cooperation with the Institute of Parasitic Diseases, Shanghai, The Academy of Medical Sciences in Hangzhou, Zhejiang Province, China and Hubei Medical College. Molecular work in Handzhou focuses on Triculinae snails, while that in Shanghai is on Oncomelania throughout China relative to predicted regional differentiation of Schistosoma japonicum.

血吸虫病仍然是主要的公共卫生问题之一 在亚洲。 直到 1980 年，亚洲的血吸虫病被归咎于 关于由蜗牛传播的日本血吸虫的医学文献 钉螺属。 今天，作为这项 NIH 资助的研究的结果， 人们认识到有一种日本血吸虫复合体传播 由两个不同的蜗牛谱系的许多蜗牛物种组成。 蜗牛 物种 - 血吸虫 sp。关联受到系统发育的限制。 该提案继续致力于揭示蜗牛的多样性 血吸虫在亚洲传播，目前重点在中国。 这 目标是 1) 继续进行详细的比较解剖学研究 Pomatiopsidae：Triculinae 蜗牛在中国南方建立 明确属和种的定义，并纳入新数据 进入 Pomatiopsidae 的系统发育，从而测试该系统发育 每增加一个新的内容。 蜗牛种-血吸虫 sp。互动 绘制在系统发育图上以评估分类单元的模式和过程 特定进化和共同进化； 2）继续分子遗传学 实验室对Triculinae类群和钉螺种群的研究 根据该计划在中国成立。 分子数据用于测试 基于解剖学的系统发育与基于分子的系统发育的一致性， 以及与血吸虫相关的蜗牛遗传学模式 传播; 3) 继续在费城进行 DNA 测序工作 Pomatiopsidae 的系统发育评估。 与寄生虫病研究所合作开展工作， 上海、浙江省杭州市医学科学院、 中国湖北医学院. 手州的分子工作重点是 Triculinae s 蜗牛，而上海的则全是钉螺 中国相对于预测的血吸虫区域分化 日本。