ANALYSIS OF MOLLUSCAN FAUNAS AND ASIAN SCHISTOSOMIASIS

软体动物区系与亚洲血吸虫病的分析

• 批准号: 3566204
• 负责人: GEORGE M DAVIS
• 金额: $ 11.52万
• 依托单位: THE ACADEMY OF NATURAL SCIENCES OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1993-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3566204
• 关键词: Asia; China; Gastropoda; India; Schistosoma; animal ecology; animal population genetics; biochemical evolution; communicable disease transmission; epizootiology; evolution; histology; host organism interaction; molecular genetics; nucleic acid hybridization; polymerase chain reaction; schistosomiasis; southeast Asia; species difference; statistics /biometry; systematic biology

It is a relatively new finding that there is a vast radiation of Triculini snails (Pomatiopsidae: Triculinae) throughout southern China actually or potentially transmitting Schistosoma and Paragonimus. The objectives here are to continue pursuing systematic, phylogenetic and biogeographic studies of Chinese Triculinae and to use the snail phylogenies to assess the patterns of co-evolution of Schistosoma and Paragonimus with these snails. The studies will involve detailed comparative anatomy, molecular genetic (allozyme population genetics and LrRNA sequencing), and biogeography. The work links to previous work done on the phylogeny of Triculinae in S.E. Asia and India. The systematics work in China is in its infancy as detailed comparative anatomical data are now available for only 17% of the Chinese Triculinae estimated to be >140 species, >12 genera. With each excursion into the provinces, new genera, and species involved in transmitting these two parasite genera are found. Work in cooperation with the Institute of Parasitic Diseases in Shanghai and Hangchow, with the Academia Sinica, Beijing and with Hubei Medical College. Collaborative work in Hangchow is synchronized with their ongoing work on Paragonimus. We will initiate allozyme molecular genetic work on Triculinae in Hangchow. Collaborative work in Shanghai is synchronized our ongoing work on the molecular genetics of Oncomelania (Pomatiopsidae: Pomatiopsinae) throughout China relative to regional genetic differentiation of Schistosoma japonicum.

特鲁里尼存在巨大的辐射，这是一个相对较新的发现 螺类（Pomatiopsidae：Troiculinae）在中国南方的分布 可能传播血吸虫和并殖吸虫 这里的目标 将继续进行系统的、系统的和地理的研究， 中国拟步甲亚科的研究，并利用螺类的生殖特性， 血吸虫和并殖吸虫的共同进化模式 蜗牛 这些研究将涉及详细的比较解剖学、分子生物学、 遗传学（等位酶群体遗传学和LrRNA测序），以及 传记。 这项工作联系到以前的工作， 拟谷盗亚科亚洲和印度。 中国的系统学工作是在 它的婴儿期作为详细的比较解剖数据，现在可用于 中国拟步甲亚科>140种的仅占17%，>12 属 每到一个省，新的属，和物种 参与传播这两种寄生虫属。 与上海市寄生虫病研究所合作 与杭州、中央研究院、北京、湖北医学 学院 杭州的协同工作与他们的 正在进行的关于并殖吸虫的研究 我们将启动等位酶分子遗传学 对杭州拟谷盗亚科的研究。 在上海的合作工作是 使我们正在进行的关于钉螺分子遗传学的工作同步， （Pomatiopsidae：Pomatiopsinae）中国各地相对于区域的 日本血吸虫的遗传分化