MOLLUSCAN FAUNAS AND ASIAN SCHISTOSOMIASIS

血吸虫病仍然是主要的公共卫生问题之一。 在亚洲。直到1980年，亚洲的血吸虫病被归因于 钉螺传播日本血吸虫的医学文献 钉螺属。今天，作为NIH赞助的这项研究的结果， 人们认识到，日本血吸虫物种复合体通过 由两个不同蜗牛谱系的多个蜗牛物种组成。蜗牛 种-血吸虫sp.它们之间的联系受到系统发育的限制。 这项提案继续侧重于揭示蜗牛的多样性 血吸虫在亚洲的传播，目前重点在中国。这个 目标是1)继续进行详细的比较解剖学研究 Pomatiopsidae：钉螺亚科遍及南方中国建立 明确属和种的定义，并纳入新的数据 进入Pomatiopsidae的系统发育，从而测试系统发育 每增加一个新成员。螺种-血吸虫sp.互动 被绘制在系统发育图上，以评估分类单元的模式和过程- 特殊进化和共同进化；2)继续分子遗传 钉螺亚科分类群和种群的实验室研究 在中国的这一计划下成立。分子数据用于测试 基于解剖学的系统发育与基于分子的系统发育的一致性， 以及与血吸虫相关的蜗牛遗传学模式 传输；3)继续在费城进行DNA序列工作 文章题目眼镜蛇科的系统发育评价。 这项工作是与寄生虫病研究所合作进行的， 上海，浙江省杭州市医学科学院， 中国和湖北医学院。汉州的分子工作重点是 钉螺，而上海的钉螺是贯穿始终的 中国与血吸虫预测的区域分化 日本产的。

Schistosomiasis continues to be one of the leading public health problems in Asia. Until 1980, schistosomiasis in Asia was attributed in the medical literature to Schistosoma japonicum transmitted by the snail genus Oncomelania. Today, as a result of this NIH sponsored research, it is recognized that there is a S. japonicum species complex transmitted by a number of snail species of two diverging snail lineages. The snail species - Schistosoma sp. associations are phylogenetically constrained. This proposal continues to focus on uncovering the diversity of snails transmitting Schistosoma in Asia, with current emphasis in China. The objectives are 1) to continue detailed comparative anatomical studies of Pomatiopsidae: Triculinae snails throughout Southern China to establish clear definitions of genera and species, and to incorporate the new data into the phylogeny of the Pomatiopsidae thereby testing that phylogeny with each new addition. The snail-species-Schistosoma sp. interactions are mapped on the phylogeny to assess pattern and process of taxon- specific evolution and coevolution; 2) to continue molecular genetic studies of Triculinae taxa and populations of Oncomelania in laboratories established under this program in China. Molecular data are used to test the congruence of anatomy-based phylogeny with molecular-based phylogeny, and the pattern of snail genetics as it related to Schistosoma transmission; 3) to continue DNA sequence work in Philadelphia for phylogenetic assessment of the Pomatiopsidae. Work is in cooperation with the Institute of Parasitic Diseases, Shanghai, The Academy of Medical Sciences in Hangzhou, Zhejiang Province, China and Hubei Medical College. Molecular work in Handzhou focuses on Triculinae snails, while that in Shanghai is on Oncomelania throughout China relative to predicted regional differentiation of Schistosoma japonicum.