MOLLUSCAN FAUNAS AND ASIAN SCHISTOSOMIASIS

软体动物与亚洲血吸虫病

• 批准号: 2650011
• 负责人: GEORGE M DAVIS
• 金额: $ 17.08万
• 依托单位: THE ACADEMY OF NATURAL SCIENCES OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2650011
• 关键词: Asia; China; Gastropoda; India; Schistosoma; animal ecology; animal genetic material tag; animal population genetics; biochemical evolution; communicable disease transmission; disease vectors; epizootiology; genetic polymorphism; histology; host organism interaction; nucleic acid hybridization; nucleic acid sequence; polymerase chain reaction; scanning electron microscopy; schistosomiasis; southeast Asia; species difference; statistics /biometry; systematic biology

Schistosomiasis continues to be one of the leading public health problems in Asia. Until 1980, schistosomiasis in Asia was attributed in the medical literature to Schistosoma japonicum transmitted by the snail genus Oncomelania. Today, as a result of this NIH sponsored research, it is recognized that there is a S. japonicum species complex transmitted by a number of snail species of two diverging snail lineages. The snail species - Schistosoma sp. associations are phylogenetically constrained. This proposal continues to focus on uncovering the diversity of snails transmitting Schistosoma in Asia, with current emphasis in China. The objectives are 1) to continue detailed comparative anatomical studies of Pomatiopsidae: Triculinae snails throughout Southern China to establish clear definitions of genera and species, and to incorporate the new data into the phylogeny of the Pomatiopsidae thereby testing that phylogeny with each new addition. The snail-species-Schistosoma sp. interactions are mapped on the phylogeny to assess pattern and process of taxon- specific evolution and coevolution; 2) to continue molecular genetic studies of Triculinae taxa and populations of Oncomelania in laboratories established under this program in China. Molecular data are used to test the congruence of anatomy-based phylogeny with molecular-based phylogeny, and the pattern of snail genetics as it related to Schistosoma transmission; 3) to continue DNA sequence work in Philadelphia for phylogenetic assessment of the Pomatiopsidae. Work is in cooperation with the Institute of Parasitic Diseases, Shanghai, The Academy of Medical Sciences in Hangzhou, Zhejiang Province, China and Hubei Medical College. Molecular work in Handzhou focuses on Triculinae snails, while that in Shanghai is on Oncomelania throughout China relative to predicted regional differentiation of Schistosoma japonicum.

血吸虫病仍然是主要的公共卫生问题之一 在亚洲 直到1980年，亚洲的血吸虫病仍被归因于 日本血吸虫螺传医学文献 钉螺属。 今天，作为NIH赞助的研究的结果， 可以认识到存在S。种间复合体 由两种不同的蜗牛谱系中的一些蜗牛物种组成。 蜗牛 种-血吸虫属种协会是遗传学限制。 这一提议继续关注揭示蜗牛的多样性 在亚洲传播血吸虫病，目前重点在中国。 的 目的是1）继续进行详细的比较解剖学研究， Pomatiopsidae：拟钉螺亚科蜗牛遍布中国南方建立 明确属和种的定义，并纳入新的数据 进入了石首鱼科的进化史， 每一个新的添加。 钉螺-种-血吸虫相互作用 绘制在进化史上，以评估分类群的模式和过程- 特异进化与协同进化; 2）继续分子遗传学 钉螺旋毛虫亚科分类群和种群的实验室研究 在中国建立了这个项目。 分子数据用于测试 基于解剖学的遗传学与基于分子的遗传学的一致性， 以及与血吸虫相关的蜗牛遗传模式 3）继续在费城进行DNA测序工作， Pomatiopsidae的系统发育评估。 与寄生虫病研究所合作开展工作， 上海，浙江杭州医学科学院， 中国湖北医学院。 在杭州的分子工作重点是 钉螺以旋毛虫为主，而上海则以钉螺为主 中国相对于预测的血吸虫病地区分化 山茱萸