IMMUNOBIOLOGY OF AFRICAN TRYPANOSOMIASIS

非洲锥虫病的免疫生物学

• 批准号: 2061812
• 负责人: John M. Mansfield
• 金额: $ 25.16万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2061812
• 关键词: B lymphocyte; T lymphocyte; Trypanosoma brucei rhodesiense; cellular immunity; cellular pathology; gene expression; histopathology; host organism interaction; immunochemistry; immunogenetics; immunoregulation; laboratory mouse; leukocyte activation /transformation; microorganism genetics; microorganism immunology; molecular pathology; nucleic acid hybridization; nucleic acid sequence; protozoal antigen; radioimmunoassay; surface antigens; tissue /cell culture; trypanosomiasis; virulence

The immunobiological relationship between host and parasite in African trypanosomiasis is the focus of this proposal. Recent evidence suggests that macrophage activation is associated with regulation of T cell responses as well as development of host resistance during infection. Accordingly we hypothesize that events controlling macrophage activation influence the course of infection. Thus, the cellular and molecular mechanisms that affect macrophage activation and parasite antigen specific T cell stimulation in infected animals, and the immunological consequences of such events, comprise the specific aims of the project. An experimental model system of the human disease will be studied in which inbred strains of mice differing in immune responsiveness and susceptibility are infected with well characterized Trypanosoma brucei rhodesiense clones that express different antigenic and biological traits.

非洲宿主与寄生虫的免疫生物学关系 锥虫病是这项建议的重点。 最近的证据表明 巨噬细胞活化与T细胞调节有关， 反应以及在感染期间宿主抗性的发展。 因此，我们假设控制巨噬细胞活化的事件 影响感染的进程。 因此，细胞和分子 影响巨噬细胞活化和寄生虫抗原的机制 感染动物中特异性T细胞刺激，以及免疫学 这些事件的后果构成了项目的具体目标。 将研究人类疾病的实验模型系统， 这些小鼠的近交系在免疫反应性方面不同， 易感性被充分表征的布氏锥虫感染 表达不同抗原性和生物学特性的罗得西亚克隆 性状