IMMUNOBIOLOGY OF AFRICAN TRYPANOSOMIASIS

这项提案的总体目标是检查免疫生物学 实验性非洲锥虫病中宿主和寄生虫的关系。 锥虫抗原特异性B和T细胞应答的作用，以及锥虫抗原特异性B和T细胞应答的作用 巨噬细胞，在提供保护和控制寄生虫血症方面 评估过了。寄生虫特异性免疫反应在诱导 病理也在确定中。最后，锥虫有能力 调节宿主对锥虫表面抗原的免疫反应 经过测量，并正在努力操纵这种寄生虫特有的 反应，从而提供更多的保护和更少的病理。因此， 拟议的研究将仔细剖析免疫学的许多方面 非洲实验性锥虫病的宿主-寄生虫关系，以及 解决热带医学和兽医中的基本重要问题 疾病。

The overall objective of this proposal is to examine the immunobiological relationship between host and parasite in experimental African trypanosomiasis. The role of trypanosome antigen-specific B and T cell responses, and the role of the macrophage, in providing protection and controlling parasitemia are being assessed. The role of the parasite-specific immune response in inducing pathology is also being determined. Finally, the ability of the trypanosome to modulate host immune responses to the trypanosome surface antigens is being measured, and efforts are being made to manipulate such parasite-specific responses so as to provide more protection and less pathology. Thus, the proposed research will carefully dissect numerous aspects of the immunology in the host-parasite relationship in experimental African trypanosomiasis, and addresses questions of fundamental importance in medical and veterinary tropical disease.