IMMUNOBIOLOGY OF AFRICAN TRYPANOSOMIASIS

非洲锥虫病的免疫生物学

• 批准号: 3133501
• 负责人: John M. Mansfield
• 金额: $ 16.46万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3133501
• 关键词: B lymphocyte; T lymphocyte; Trypanosoma; animal morbidity; cellular immunity; histopathology; host organism interaction; immunization; immunosuppression; macrophage; microorganism immunology; microscopy; protozoal antigen; radioimmunoassay; tissue /cell culture; trypanosomiasis

The overall objective of this proposal is to examine the immunobiological relationship between host and parasite in experimental African trypanosomiasis. The role of trypanosome antigen-specific B and T cell responses, and the role of the macrophage, in providing protection and controlling parasitemia are being assessed. The role of the parasite-specific immune response in inducing pathology is also being determined. Finally, the ability of the trypanosome to modulate host immune responses to the trypanosome surface antigens is being measured, and efforts are being made to manipulate such parasite-specific responses so as to provide more protection and less pathology. Thus, the proposed research will carefully dissect numerous aspects of the immunology in the host-parasite relationship in experimental African trypanosomiasis, and addresses questions of fundamental importance in medical and veterinary tropical disease.

本提案的总体目标是检查免疫生物学 实验性非洲锥虫宿主与寄生虫的关系 锥虫抗原特异性B和T细胞应答的作用，以及 巨噬细胞，在提供保护和控制寄生虫血症， 评估。 寄生虫特异性免疫应答在诱导 病理学也正在确定中。 最后，锥虫能够 调节宿主对锥虫表面抗原的免疫应答， 测量，并正在努力操纵这种寄生虫特异性 反应，以提供更多的保护和更少的病理。 因此 拟议的研究将仔细剖析免疫学的许多方面， 实验性非洲锥虫的宿主-寄生虫关系，以及 解决热带医学和兽医学中的基本重要问题 疾病