IMMUNOBIOLOGY OF AFRICAN TRYPANOSOMIASIS

非洲宿主与寄生虫的免疫生物学关系 锥虫病是这项提案的重点。最近的证据表明 巨噬细胞的激活与T细胞的调节有关 在感染期间的反应以及宿主抵抗力的发展。 因此，我们假设控制巨噬细胞激活的事件 影响感染的进程。因此，细胞和分子 影响巨噬细胞活化和寄生虫抗原的机制 感染动物的特异性T细胞刺激及其免疫学 这些事件的后果，构成了项目的具体目标。 人类疾病的实验模型系统将在#年进行研究。 哪些近亲繁殖的小鼠品系在免疫反应性和 易感性感染具有良好特征的布鲁氏锥虫 表达不同抗原性和生物学特性的罗得志克隆 特征。

The immunobiological relationship between host and parasite in African trypanosomiasis is the focus of this proposal. Recent evidence suggests that macrophage activation is associated with regulation of T cell responses as well as development of host resistance during infection. Accordingly we hypothesize that events controlling macrophage activation influence the course of infection. Thus, the cellular and molecular mechanisms that affect macrophage activation and parasite antigen specific T cell stimulation in infected animals, and the immunological consequences of such events, comprise the specific aims of the project. An experimental model system of the human disease will be studied in which inbred strains of mice differing in immune responsiveness and susceptibility are infected with well characterized Trypanosoma brucei rhodesiense clones that express different antigenic and biological traits.