ACCURATE IN VIVO ULTRASONIC SCATTERING ASSESSMENTS

准确的体内超声波散射评估

• 批准号: 2089759
• 负责人: JAMES A. ZAGZEBSKI
• 金额: $ 15.86万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2089759
• 关键词: clinical biomedical equipment; diagnosis quality /standard; disease /disorder model; human subject; image processing; kidney imaging /visualization; liver cirrhosis; liver disorder diagnosis; noninvasive diagnosis; phantom model; radiobiology; ultrasonography

The long term goals of this research are to produce accurate, quantitative assessments of ultrasound scattering in vivo, to improve the noninvasive diagnostic capabilities of medical ultrasound. This research will center on the diagnosis and monitoring of diffuse liver disease with ultrasound and the detection and differentiation of focal lesions, especially when these are masked by diffuse disease conditions. The hypothesis is that quantitative backscatter images depicting backscatter levels and backscatter frequency dependence, as well as acoustic parameters derived from backscatter signals, including attenuation, scatterer size estimated from spatial auto correlation functions and scatterer number densities, will provide improved differentiation between normal and diseased conditions. Instrumentation will be adopted to expand the frequency range of liver backscatter estimates, and a data base on backscatter and attenuation coefficients for normal individuals will be expanded. Newly derived parameters for assessing scatterer size and number density will be further evaluated in phantoms, including novel ones constructed to model liver disease. When thoroughly understood, values for these parameters will be obtained for normal liver. Work will continue to measure backscatter, attenuation, and when available, scatterer size and number density in a large group of patients with diffuse liver disease. These studies will be extended to individuals with proven focal lesions in the liver, exploring new ways to acquire and display echo data. Finally, animals models for fatty infiltration in the liver, cirrhosis and steroid induced hepatophy will be used to further our understanding of acoustic changes accompanying liver disease.

这项研究的长期目标是产生准确、定量的结果 体内超声散射的评估，以提高无创性 医学超声的诊断能力。 这项研究将集中 弥漫性肝病的超声诊断和监测 以及局灶性病变的检测和鉴别，尤其是当 这些都被弥漫性疾病所掩盖。 假设是 描述反向散射水平的定量反向散射图像 反向散射频率依赖性，以及导出的声学参数 根据反向散射信号，包括衰减、估计的散射体尺寸 根据空间自相关函数和散射体数量密度， 将提供更好的正常和患病之间的区分 状况。 将采用仪器来扩大肝脏的频率范围 反向散射估计以及反向散射和衰减的数据库 正常个体的系数将扩大。 新衍生的 用于评估散射体尺寸和数量密度的参数将进一步 在模型中进行评估，包括构建肝脏模型的新型模型 疾病。 当彻底理解后，这些参数的值将是 获得正常肝脏。 测量反向散射的工作将继续进行， 衰减，以及当可用时，散射体尺寸和数量密度 一大群患有弥漫性肝病的患者。 这些研究将 扩展到已证实肝脏局灶性病变的个体，探索 采集和显示回波数据的新方法。最后，动物模型 肝脏脂肪浸润、肝硬化和类固醇诱发的肝病 将用于进一步我们对伴随的声学变化的理解 肝脏疾病。