ACCURATE IN VIVO ULTRASONIC SCATTERING ASSESSMENTS

准确的体内超声波散射评估

• 批准号: 2089760
• 负责人: JAMES A. ZAGZEBSKI
• 金额: $ 14.99万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2089760
• 关键词: clinical biomedical equipment; diagnosis quality /standard; disease /disorder model; human subject; image processing; kidney imaging /visualization; liver cirrhosis; liver disorder diagnosis; noninvasive diagnosis; phantom model; radiobiology; ultrasonography

The long term goals of this research are to produce accurate, quantitative assessments of ultrasound scattering in vivo, to improve the noninvasive diagnostic capabilities of medical ultrasound. This research will center on the diagnosis and monitoring of diffuse liver disease with ultrasound and the detection and differentiation of focal lesions, especially when these are masked by diffuse disease conditions. The hypothesis is that quantitative backscatter images depicting backscatter levels and backscatter frequency dependence, as well as acoustic parameters derived from backscatter signals, including attenuation, scatterer size estimated from spatial auto correlation functions and scatterer number densities, will provide improved differentiation between normal and diseased conditions. Instrumentation will be adopted to expand the frequency range of liver backscatter estimates, and a data base on backscatter and attenuation coefficients for normal individuals will be expanded. Newly derived parameters for assessing scatterer size and number density will be further evaluated in phantoms, including novel ones constructed to model liver disease. When thoroughly understood, values for these parameters will be obtained for normal liver. Work will continue to measure backscatter, attenuation, and when available, scatterer size and number density in a large group of patients with diffuse liver disease. These studies will be extended to individuals with proven focal lesions in the liver, exploring new ways to acquire and display echo data. Finally, animals models for fatty infiltration in the liver, cirrhosis and steroid induced hepatophy will be used to further our understanding of acoustic changes accompanying liver disease.

这项研究的长期目标是产生准确的、定量的 评估体内超声散射，以提高无创性 医用超声的诊断能力。这项研究将集中在 超声对弥漫性肝病的诊断和监测 以及局灶性病变的检测和鉴别，尤其是当 这些都被弥漫的疾病状况掩盖了。假设是这样的 描述后向散射水平的定量后向散射图像和 后向散射频率依赖关系以及导出的声学参数 根据后向散射信号，包括衰减、散射体大小估计 根据空间自相关函数和散射体数量密度， 将改善正常和疾病之间的区别 条件。 将采用仪器扩大肝脏的频率范围 后向散射估计，以及后向散射和衰减数据库 正常个体的系数将被扩展。新派生的 用于评估散射体大小和数密度的参数将进一步 在模型中进行评估，包括为模拟肝脏而构建的新模型 疾病。彻底了解后，这些参数的值将为 取自正常肝脏。工作将继续测量后向散射， 衰减，以及散射体大小和数密度(如果可用) 一大群弥漫性肝病患者。这些研究将是 扩展到有肝脏局灶性病变的个人，探索 获取和显示回波数据的新方法。最后，动物模型 脂肪在肝脏、肝硬变和类固醇诱导的嗜肝症中的渗透 将被用来加深我们对伴随着 肝病。