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New Ultrasound Imaging Paradigms

新的超声成像范例

基本信息

批准号：
6802695
负责人：
JAMES A. ZAGZEBSKI
金额：
$ 21.41万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-19 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6802695
关键词：
adult human (21+)bioimaging /biomedical imaging breast neoplasm /cancer diagnosis clinical research computer assisted diagnosis human subject phantom model technology /technique development ultrasonography women&apos s health

项目摘要

DESCRIPTION (provided by applicant): In gray scale imaging, the most widely used clinical ultrasound modality, only the amplitudes of ultrasound echo signals are detected and displayed as dots on the monitor. However, the emergence of a new class of computer-controlled ultrasound scanning machines represents an outstanding opportunity to implement novel parametric imaging modes that should significantly compliment conventional scanning paradigms. Our goals are to implement and test scatterer size, integrated backscatter and attenuation imaging modes on a clinical scanner. The scanner is also being equipped with various elastography imaging, which will enable these data also to be included. Parametric images will be constructed by applying data reduction techniques that incorporate echo data from a reference phantom to account for imaging system and transducer dependencies of echo data. Scatterer size images will be constructed by applying least squares data reduction routines to fit spectral data to a model, where a free parameter represents the scatterer size. Integrated backscatter is considered the best representation of the scattered energy from a region, where corrections for attenuation and system dependencies on echo data are applied. New attenuation images and region of interest attenuation calculations will be incorporated that also apply reference phantom methods. Means for prerecording reference phantom information into the scanner memory will be evaluated, which would provide absolute internally calibrated ultrasound image data. Although images of scatterer size, integrated backscatter, and tissue strain have been previously reported, they have been plagued by the presence of noise artifacts especially for image data that are generated using echo signal spectra. We propose to improve the SNR of parametric images by spatially compounding parametric images obtained using RF data acquired at different insonification angles of the ultrasound beam. Angular compounding of the parametric images allows multiple, independent estimations of spectral parameters from each image voxel. In addition, angular compounding provides a means of improving images of axial tissue strain (elastograms) obtained by weighted angular compounding. The work is primarily directed towards ultrasound breast tissue imaging, where a research scanner being acquired by the Departments of Medical Physics and Radiology is being sited. Preliminary data will be generated for this application.

描述（由申请人提供）：在灰度成像（最广泛使用的临床超声模态）中，仅超声回波信号的幅度被检测并在监视器上显示为点。然而，一类新的计算机控制的超声扫描机器的出现代表了一个杰出的机会，实现新的参数成像模式，应显着恭维传统的扫描范例。我们的目标是在临床扫描仪上实现和测试散射体尺寸、背向散射积分和衰减成像模式。扫描仪还配备了各种弹性成像，这将使这些数据也被包括在内。将通过应用数据简化技术构建参数图像，该技术结合了来自参考体模的回波数据，以说明回波数据的成像系统和换能器依赖性。散射体尺寸图像将通过应用最小二乘数据简化程序来构建，以将光谱数据拟合到模型中，其中自由参数表示散射体尺寸。积分后向散射被认为是来自一个区域的散射能量的最佳表示，其中应用了对回波数据的衰减和系统依赖性的校正。将纳入新的衰减图像和感兴趣区域衰减计算，也应用参考体模方法。将评价将参考体模信息预先记录到扫描仪存储器中的方法，这将提供绝对内部校准的超声图像数据。尽管先前已经报道了散射体尺寸、积分反向散射和组织应变的图像，但是它们一直受到噪声伪影的存在的困扰，特别是对于使用回波信号谱生成的图像数据。我们建议通过在空间上复合使用在超声束的不同声穿透角度处采集的RF数据获得的参数图像来提高参数图像的SNR。参数图像的角度复合允许对来自每个图像体素的谱参数进行多个独立估计。此外，角度复合提供了一种改善通过加权角度复合获得的轴向组织应变图像（弹性图）的方法。这项工作主要针对超声乳腺组织成像，医学物理学和放射学系正在购置一台研究扫描仪。将为此应用程序生成初步数据。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Spatial-angular compounding for elastography using beam steering on linear array transducers.

使用线性阵列传感器上的波束控制进行弹性成像的空间角度复合。

DOI：
10.1118/1.2168429
发表时间：
2006
期刊：
Medical physics
影响因子：
3.8
作者：
Rao,Min;Chen,Quan;Shi,Hairong;Varghese,Tomy
通讯作者：
Varghese,Tomy

Noise reduction using spatial-angular compounding for elastography

DOI：
10.1109/tuffc.2004.1320824
发表时间：
2004-08
期刊：
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
影响因子：
0
作者：
U. Techavipoo;Quan Chen;Tomy Varghese;J. Zagzebski;Ernest L. Madsen
通讯作者：
U. Techavipoo;Quan Chen;Tomy Varghese;J. Zagzebski;Ernest L. Madsen

Optimization of angular and frequency compounding in ultrasonic attenuation estimations.

超声衰减估计中角度和频率复合的优化。

DOI：
10.1121/1.1879212
发表时间：
2005
期刊：
The Journal of the Acoustical Society of America
影响因子：
0
作者：
Tu,Haifeng;Zagzebski,JamesA;Gerig,AnthonyL;Chen,Quan;Madsen,ErnestL;Hall,TimothyJ
通讯作者：
Hall,TimothyJ

Estimation of displacement vectors and strain tensors in elastography using angular insonifications.

使用角度声穿透估计弹性成像中的位移矢量和应变张量。