ACCURATE IN VIVO ULTRASONIC SCATTERING ASSESSMENTS

准确的体内超声波散射评估

• 批准号: 6124565
• 负责人: JAMES A. ZAGZEBSKI
• 金额: $ 17.23万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6124565
• 关键词: bioimaging /biomedical imaging; biopsy; clinical biomedical equipment; clinical research; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder model; human subject; image processing; kidney imaging /visualization; laboratory rabbit; laboratory rat; liver cirrhosis; liver disorder diagnosis; liver neoplasms; noninvasive diagnosis; phantom model; radiobiology; ultrasonography

DESCRIPTION (Adapted from Applicant's Abstract): The long term objectives of this research are to develop quantitative methods that will enhance the capabilities of medical ultrasound to diagnose focal and diffuse liver disease. Progress during the current grant period has led to in vivo measurements of backscatter and attenuation in normal livers and livers of patients with diffuse disease. In addition new ways to quantify spatial autocorrelation functions from RF echo data and backscatter and attenuation coefficients with a clinical scanner were introduced. The clinical imager backscatter and attenuation technique has been termed "VSA." In the proposed grant period, the VSA method will be investigated thoroughly, defining limitations of accuracy and requirements for reference phantoms when broad-bandwidth instruments are used for backscatter and attenuation estimations. Clinical utility of VSA in veterinary medicine will be studied by applying it to ultrasound scans of the liver, prostate and spleen in sites where correlations with histology will be available. In addition, investigations using both RF echo data and VSA will continue to define "ideal" B-mode imaging and acoustic scattering characteristics of liver masses obtained during partial hepatic resections. We will define how image contrast, gray scale texture and RF echo signal parameters vary with frequency to help optimize imaging in intraoperative and laparoscopic ultrasound. We also will study the extent that ultrasound echo features of these tumors, obtained in an ideal environment, are degraded during sound transmission through the patient body wall. Extensive use will be made of tissue mimicking phantoms to test methodology and to understand image and echo degradation.

描述（改编自申请人摘要）：长期目标 这项研究的目的是开发定量方法， 医学超声诊断局灶性和弥漫性肝脏的能力 疾病 在目前的赠款期内取得的进展， 测量正常肝脏和肝脏的后向散射和衰减， 弥漫性疾病患者。 此外，量化空间的新方法 来自RF回波数据和反向散射和衰减的自相关函数 系数与临床扫描仪进行了介绍。 临床成像反向散射和衰减技术已被称为 "VSA。"在建议的拨款期内， 彻底，定义准确度限制和参考要求 当宽带仪器用于反向散射时， 衰减估计。 VSA在兽医中的临床应用 将通过应用于肝脏，前列腺， 和脾脏，其中与组织学的相关性将是可用的。 在 此外，将继续使用射频回波数据和VSA进行调查， 定义"理想的" B模式成像和声散射特性， 部分肝切除术中获得的肝肿块。 我们将定义如何 图像对比度、灰度纹理和RF回波信号参数随 频率有助于优化术中和腹腔镜成像 超声. 我们还将研究在何种程度上，超声回波特征的 这些在理想环境中获得的肿瘤， 通过患者的体壁传播。 将广泛使用 组织模拟体模，以测试方法学并理解图像， 回波衰减