NMR PROTON CHEMICAL SHIFT IMAGING

核磁共振质子化学位移成像

• 批准号: 2090183
• 负责人: BRUCE R ROSEN
• 金额: $ 31.18万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2090183
• 关键词: Huntington's disease; Parkinson's disease; bioenergetics; brain disorder diagnosis; cerebral ischemia /hypoxia; computer simulation; diagnosis quality /standard; disease /disorder model; electron transport; human subject; laboratory rabbit; laboratory rat; lactates; magnetic resonance imaging; neural degeneration; nuclear magnetic resonance spectroscopy; oxygen transport; phantom model; positron emission tomography; technology /technique

The goal of this research is to refine the capacity of proton NMR to acquire images displaying chemical shift spectral information, and to assess the role of these methods in vivo in clinical and basic research. As in our initial submission, two areas of investigation will be studied in detail. First, quantitative techniques of lipid and water imaging, evaluated during the initial funding period, will be further extended to measure additional spectral characteristics. These will include spectral resonance line broadening measured using an asymmetric spin echo (ASE) method, and scalar coupled fraction (SCF) measured using multiple quantum techniques. Two applications are planned. Following on the success of pilots studies funded during the initial study period, the clinical utility of quantitative analysis of lipid and water resonance concentration, relaxation times, and newly developed measures of spectral line widths will be evaluated in disorders of bone marrow. This will include detailed longitudinal studies of myeloproliferative disorders, and pilot studies of chemical shift imaging (CSI) techniques to measure marrow iron stores. Research will also begin on quantitative spectral imaging of atherosclerotic plaque. Work will focus on characterization of fatty plaques with lipid- sensitive and multiple quantum pulse sequences, and atherosclerotic arterial thrombus with iron-sensitive line width mapping. These studies will be directed towards establishing quantitative CSI as a non-invasive tool for evaluating the response of arterial lesions to new interventions such as laser angioplasty. Second, mapping lactate in cerebral ischemia will form the cornerstone of studies of brain physiology. Technical issues to be addressed will include improved methods of lipid suppression (previous work having demonstrated solutions to the problem of in vivo water suppression), and comparison between field strengths. Physiologic correlates to lactate maps including MR and PET measures of cerebral blood flow, brain pH and oxygen metabolism, will be used in both global hypoxia and focal ischemia to address questions of brain energy metabolism and pH regulation.

这项研究的目标是提高质子核磁共振的能力 获取显示化学位移光谱信息的图像， 并评估这些方法在临床和体内的作用 基础研究。 正如我们最初提交的内容一样，有两个领域 调查将进行详细研究。 首先，脂质和水成像的定量技术， 在初始资助期间进行评估，将进一步 扩展以测量额外的光谱特性。 这些 将包括使用测量的光谱共振线展宽 不对称自旋回波 (ASE) 方法和标量耦合分数 (SCF) 使用多种量子技术测量。 两个应用 已计划。 继资助的试点研究取得成功之后 在最初的研究期间，临床效用 脂质和水共振浓度的定量分析， 弛豫时间和新开发的谱线测量 宽度将在骨髓疾病中进行评估。 这将 包括骨髓增殖的详细纵向研究 疾病和化学位移成像 (CSI) 的初步研究 测量骨髓铁储备的技术。 研究也将开始 动脉粥样硬化斑块的定量光谱成像。 工作 将重点关注脂质斑块的表征 敏感和多量子脉冲序列，以及动脉粥样硬化 动脉血栓与铁敏感线宽测绘。 这些 研究将旨在建立定量 CSI 作为 用于评估动脉病变反应的非侵入性工具 新的干预措施，例如激光血管成形术。 其次，绘制脑缺血中的乳酸图谱将形成 脑生理学研究的基石。 技术问题 解决的问题将包括改进脂质抑制方法 （以前的工作已经证明了问题的解决方案 体内水抑制），以及场强之间的比较。 生理学与乳酸图（包括 MR 和 PET）相关 脑血流量、脑 pH 值和氧代谢的测量， 将用于全身缺氧和局灶性缺血，以解决 脑能量代谢和 pH 调节问题。