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A new biotech process for xylitol production from ARCITEKBio Ltd.

ARCITEKBio Ltd. 生产木糖醇的新生物技术工艺。

基本信息

批准号：
105111
负责人：
金额：
$ 27.59万
依托单位：
ARCITEKBIO LTD
依托单位国家：
英国
项目类别：
Study
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=105111
关键词：
new biotech process xylitol production

项目摘要

Xylitol is a sweetener found naturally in fresh fruit and has 33% fewer calories than table sugar, inhibits tooth decay, is metabolised independently of insulin in the body, and as such has application in maintaining dietary, dental and diabetic health. While xylitol is present in plants, the quantities are so low that it is not economically feasible to extract it commercially and industrial production relies on chemical synthesis that uses acid, high temperature, pressure and a heavy metal catalyst to produce xylitol. Using proprietary microbes, the start-up company ARCITEKBio Ltd. has developed an environmentally friendly fermentation process to produce xylitol using crop waste such as wheat straw. The objective of this project is to enable ARCITEKBio Ltd. to scale-up the xylitol production process, validate the techno-economics of this industrial biotechnology (IB) against the traditional chemical synthesis method. Once the pure product is produced at scale, it will be shared with collaborative end-users for beta-testing and early stage regulatory assessments. With the market value for xylitol anticipated to reach £1 billion by 2025 and growing at a compound annual growth rate of 6.2%, ARCITEKBio Ltd is looking to secure further funding and partners within the supply chain to ultimately commercialise the IB-mediated production of xylitol in the UK and possibly further afield.

木糖醇是一种天然存在于新鲜水果中的甜味剂，热量比蔗糖少 33%，可抑制蛀牙，在体内的代谢独立于胰岛素，因此可用于维持饮食、牙齿和糖尿病健康。虽然木糖醇存在于植物中，但其含量非常低，以至于商业提取它在经济上不可行，工业生产依赖于使用酸、高温、压力和重金属催化剂的化学合成来生产木糖醇。初创公司 ARCITEKBio Ltd. 利用专有微生物，开发了一种环保发酵工艺，利用麦秆等作物废料生产木糖醇。该项目的目标是使 ARCITEKBio Ltd. 能够扩大木糖醇生产工艺，对照传统化学合成方法验证这种工业生物技术 (IB) 的技术经济性。一旦纯产品大规模生产，它将与协作最终用户共享，以进行 beta 测试和早期监管评估。木糖醇的市场价值预计到 2025 年将达到 10 亿英镑，并以 6.2% 的复合年增长率增长，ARCITEKBio Ltd 正在寻求在供应链内获得更多资金和合作伙伴，以最终将 IB 介导的木糖醇生产在英国甚至更远的地方商业化。