BREAST CANCER AND THE ENVIRONMENT ON LONG ISLAND

乳腺癌与长岛的环境

• 批准号: 2109980
• 负责人: MARILIE D. GAMMON
• 金额: $ 0.4万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-08 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2109980
• 关键词: BREAST; CANCER; ENVIRONMENT; LONG; ISLAND

This proposal is a collaborative effect among New York City and Long Island researchers to determine whether environmental contaminants increase the risk of breast cancer among women on Long Island, New York. Concern about this issue among Long Island residents led to federal legislation mandating such a study. Recently, several studies suggest that certain environmental exposures, primarily some organochlorines (commonly used as pesticides), effect estrogen production under laboratory conditions, increase mammary tumors in animals, and many increase a woman's risk of breast cancer. Possible route through which organochlorine compounds (OCC) may effect breast cancer risk include estrogen metabolism. Further studies have linked residence near hazardous waste sites or chemical facilities with breast cancer risk. Although the exact exposures have not been identified, putative agents derived from such exposures may include polycyclic aromatic hydrocarbons (PAH), ubiquitous mammary carcinogens that are estrogenic in some in vitro test systems. The primary aim of the proposed study is to determine whether OCC (DDE, PCBs, chlordane) and PAH are associated with breast cancer risk among Long Island women. This investigation will be a five-year, population-based case-control study. Cases will be residents of Nassau and Suffolk counties who are newly diagnosed with primary breast cancer during a 12-month period. Cases will be identified through frequent review of pathology/cytology records. Population-based controls will be frequency matched to cases by 5-year age groups, and identified using random digit dialing and the Health Care and Finance Administration rosters. Completed in-home interviews are expected for 80% of eligible subjects (1,623 cases and 1,623 controls). About 60% of all respondents are expected to provide biologic specimens; for cases, specimens will be collected prior to treatment, whereas for controls, specimens will be obtained at the interview. Home samples of water, soil, and dust will also be collected among women who have resided in their homes for 15 years or longer. A random sample of blood and urine samples from 400 cases and 400 counts will be analyzed. Laboratory analyses include determination of OCC in blood, PAH-DNA adduct, and urinary markers of estrogen metabolism. The 650 home samples of soil, water, and dust will be assayed for pesticides and PAH. For all respondents, historic environmental exposure to these compounds will also be calculated using geographic modeling techniques, as well as self-reports of occupational and residential exposure. To estimate the association between breast cancer and exposure to OCC or PAH, adjusted odd; ratios and corresponding confidence intervals will be calculated using standard statistical methods. Effect modification by estrogen or carcinogen metabolism, and other factors (such as estrogen- receptor status, menopausal status, family history, or nutrition) will be explored where possible. The effect of established and suspected risk factors on breast cancer risk among Long Island women will also be assessed.

这项提议是纽约市和Long之间的合作成果 岛屿研究人员将确定环境污染物是否 增加纽约长岛女性患乳腺癌的风险。 长岛居民对这一问题的担忧导致了联邦 强制进行这项研究的立法。最近，几项研究表明 某些环境暴露，主要是一些有机氯 (通常用作杀虫剂)，影响雌激素的产生 实验室条件下，增加了动物的乳腺肿瘤，以及许多 增加女性患乳腺癌的风险。可能通过的路线 有机氯化合物(OCC)可能会影响乳腺癌风险，包括 雌激素代谢。进一步的研究表明，危险住所附近 有乳腺癌风险的废物场地或化学设施。尽管 确切的接触情况尚未确定，推定的病原体来自 这种暴露可包括多环芳烃(PAH)， 在某些体外试验中具有雌激素活性的普遍存在的乳腺癌致癌物质 系统。拟议研究的主要目的是确定 OCC(DDE、多氯联苯、氯丹)和多环芳烃与乳腺癌风险相关 在长岛的女性中。 这项调查将是一项为期五年的以人口为基础的病例对照研究 学习。病例将是拿骚和萨福克县的居民 在12个月的时间里新诊断出患有原发性乳腺癌。 病例将通过经常复查病理/细胞学来确定 唱片。以人口为基础的控制措施将通过以下方式与病例相匹配 5岁年龄组，并使用随机数字拨号和 医疗保健和财务管理花名册。在家完成 预计80%的合格受试者将接受面谈(1,623例和 1,623个对照)。约60%的受访者预计将提供 生物标本；对于情况，标本将在 治疗，而对于对照，将在 面试。还将收集家庭中的水、土壤和灰尘样本 在家中居住了15年或更长时间的妇女。一个 随机抽取400例患者和400例患者的血、尿标本 将会被分析。实验室分析包括测定OCC 血液、多环芳烃-DNA加合物和尿雌激素代谢标志物。这个 将对650个家庭土壤、水和灰尘样本进行杀虫剂检测。 和PAH。对于所有受访者，历史上对这些产品的环境暴露 化合物也将使用地理建模技术进行计算， 以及职业和住宅暴露的自我报告。至 估计乳腺癌与接触OCC或 PAH，调整后的奇数比和相应的置信度区间 使用标准统计方法计算。效果修改方式 雌激素或致癌物代谢，以及其他因素(如雌激素- 受体状态、更年期状态、家族史或营养)将 在可能的情况下被探索。已确定风险和疑似风险的影响 长岛妇女患乳腺癌风险的因素也将是 评估过了。