BREAST CANCER AND THE ENVIRONMENT ON LONG ISLAND

乳腺癌与长岛的环境

• 批准号: 2008763
• 负责人: MARILIE D. GAMMON
• 金额: $ 263.77万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-08 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2008763
• 关键词: BREAST; CANCER; ENVIRONMENT; LONG; ISLAND

This proposal is a collaborative effect among New York City and Long Island researchers to determine whether environmental contaminants increase the risk of breast cancer among women on Long Island, New York. Concern about this issue among Long Island residents led to federal legislation mandating such a study. Recently, several studies suggest that certain environmental exposures, primarily some organochlorines (commonly used as pesticides), effect estrogen production under laboratory conditions, increase mammary tumors in animals, and many increase a woman's risk of breast cancer. Possible route through which organochlorine compounds (OCC) may effect breast cancer risk include estrogen metabolism. Further studies have linked residence near hazardous waste sites or chemical facilities with breast cancer risk. Although the exact exposures have not been identified, putative agents derived from such exposures may include polycyclic aromatic hydrocarbons (PAH), ubiquitous mammary carcinogens that are estrogenic in some in vitro test systems. The primary aim of the proposed study is to determine whether OCC (DDE, PCBs, chlordane) and PAH are associated with breast cancer risk among Long Island women. This investigation will be a five-year, population-based case-control study. Cases will be residents of Nassau and Suffolk counties who are newly diagnosed with primary breast cancer during a 12-month period. Cases will be identified through frequent review of pathology/cytology records. Population-based controls will be frequency matched to cases by 5-year age groups, and identified using random digit dialing and the Health Care and Finance Administration rosters. Completed in-home interviews are expected for 80% of eligible subjects (1,623 cases and 1,623 controls). About 60% of all respondents are expected to provide biologic specimens; for cases, specimens will be collected prior to treatment, whereas for controls, specimens will be obtained at the interview. Home samples of water, soil, and dust will also be collected among women who have resided in their homes for 15 years or longer. A random sample of blood and urine samples from 400 cases and 400 counts will be analyzed. Laboratory analyses include determination of OCC in blood, PAH-DNA adduct, and urinary markers of estrogen metabolism. The 650 home samples of soil, water, and dust will be assayed for pesticides and PAH. For all respondents, historic environmental exposure to these compounds will also be calculated using geographic modeling techniques, as well as self-reports of occupational and residential exposure. To estimate the association between breast cancer and exposure to OCC or PAH, adjusted odd; ratios and corresponding confidence intervals will be calculated using standard statistical methods. Effect modification by estrogen or carcinogen metabolism, and other factors (such as estrogen- receptor status, menopausal status, family history, or nutrition) will be explored where possible. The effect of established and suspected risk factors on breast cancer risk among Long Island women will also be assessed.

该提案是纽约市和朗之间的协作效应 岛上的研究人员，以确定是否环境污染物 增加了纽约长岛妇女患乳腺癌的风险。 长岛居民对这一问题的担忧导致联邦政府 立法授权进行这样的研究。最近，一些研究表明， 某些环境暴露，主要是一些有机氯， （通常用作杀虫剂），影响雌激素的产生， 实验室条件下，增加乳腺肿瘤的动物，和许多 增加女性患乳腺癌的风险。可能的路线 有机氯化合物（OCC）可能影响乳腺癌风险，包括 雌激素代谢进一步的研究表明， 有患乳腺癌风险的废物处理场或化学设施。虽然 确切的接触尚未确定，推定的代理人来自 这种暴露可以包括多环芳烃（PAH）， 在某些体外试验中具有雌激素性的普遍存在的乳腺致癌物 系统.这项研究的主要目的是确定是否 OCC（DDE、PCBs、氯代巴比妥）和PAH与乳腺癌风险相关 长岛女人中 本次调查将是一个为期五年的，以人群为基础的病例对照研究 study.病例将是拿骚和萨福克县的居民， 在12个月内新诊断为原发性乳腺癌。 将通过频繁审查病理学/细胞学来识别病例 记录基于人群的对照将与病例频率匹配， 5-年年龄组，并确定使用随机数字拨号和 卫生保健和财政管理局名册。在家完成 预计80%的合格受试者（1，623例， 1，623例对照）。预计约60%的受访者将提供 生物标本;对于病例，标本将在 处理，而对于对照，将在 采访还将收集水，土壤和灰尘的家庭样本 在家中居住15年或更长时间的妇女中。一 随机抽取400例患者的血液和尿液样本，400个计数 将被分析。实验室分析包括测定 血液、PAH-DNA加合物和雌激素代谢的尿标志物。的 将对650个家庭的土壤、水和灰尘样本进行农药检测 和PAH。对于所有受访者来说，历史上环境暴露于这些 还将使用地理建模技术计算化合物， 以及职业和住宅暴露的自我报告。到 估计乳腺癌与暴露于OCC之间的关联，或 PAH，校正的比值;比值和相应的置信区间将 使用标准统计方法计算。效果修改 雌激素或致癌物质代谢，以及其他因素（如雌激素， 受体状态、绝经状态、家族史或营养）将 在可能的情况下进行探索。确定和怀疑风险的影响 长岛妇女患乳腺癌风险的因素也将 评估。