REGULATION IN MULTIGENE FAMILIES

这是对继续使用PO1-GM31689的资金请求。中环 这项提案的目标涉及多基因内的基因调控。 家庭，这代表了四个人的共同利益 参与的独立调查人员。强大的技术 这四个实验室利用重组DNA技术进行研究 不同的具有生物重要性的大分子群。其中大多数都是 分子是多基因家族的成员，表达在 发展计时的时尚。所有项目的一个关键方面是组织- 蛋白质生产的特定调控。计划项目机制 作为实现每个个体所需的技术而被请求 项目不仅需要几个人的智力互动 调查人员，但除此之外，资源和设备的汇集。 由于本计划项目是在#年的第11至15年提交的 支持，这一筹资机制的一个非常重要的成果已经出现。 我们四个人将在大约10个月后搬到一个楼层 目前正在建设中的生物医学研究设施。 尽管我们最初与不同的部门和不同的 研究生课程，我们将被安排在一起学习《分子免疫学》 这将进一步促进智力和身体上的互动，并 为我们长期的富有成效的互动提供了令人信服的证据。

This represents a request for funds to continue PO1-GM31689. The central goals of this proposal concern the regulation of genes within multigene families, which represents the common interest among the four participating independent investigators. The powerful techniques of recombinant DNA technology are utilized by the four laboratories to study distinct groups of biologically important macromolecules. Most of these molecules are members of multigene families that are expressed in a developmentally-timed fashion. A key aspect of all projects is the tissue- specific regulation of protein production. The program project mechanism is requested as the technologies needed to carry out each individual project require not only the intellectual interaction of several investigators, but in addition, the pooling of resources and equipment. As this program project is submitted for its eleventh to fifteenth year of support, a very significant outcome of this funding mechanism has emerged. The four of us will be moving in approximately 10 months to occupy a floor of a biomedical research facility that is currently under construction. Despite our initial association with different departments and different graduate programs, we will be housed together as a "Molecular Immunology Center". This will further interactions both intellectual and physical and provides persuasive evidence of our long standing productive interaction.