Novel genetic tools for application in insect pest control

用于害虫防治的新型遗传工具

• 批准号: 131176
• 金额: $ 29.88万
• 依托单位: OXITEC LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=131176
• 关键词: Novel; genetic; tools; application; insect

Translational synthetic biology is a relatively new approach to the development of precisely targeted, clean methods for controlling pest insects – agricultural pests and disease vectors such as mosquitoes. The first products have already been successfully field-tested. However, the range of available parts from which to construct the necessary genetic circuits is narrow, and the range of feasible genetic circuits correspondingly limited. In this project we will characterise and test additional components, in particular genetic switches allowing precise control over gene expression. In accord with the principles of synthetic biology, concepts of modularity, reusability and abstraction will be built in from the outset. Both designs and components will be tested in distantly related insect species to assess the extent to which these can be considered ‘standardised’ across different insects, or are likely to require species-specific modification and, if the latter, to derive general rules indicating how to do this.

转化合成生物学是一种相对较新的方法，用于开发精确靶向的清洁方法来控制害虫-农业害虫和疾病载体，如蚊子。第一批产品已经成功地进行了现场测试。然而，用来构建必要的遗传电路的可用部件的范围很窄，并且可行的遗传电路的范围相应地受到限制。在这个项目中，我们将研究和测试额外的组件，特别是基因开关，可以精确控制基因表达。与合成生物学的原则雅阁，模块化，可重用性和抽象的概念将从一开始就建立起来。设计和组件都将在远亲昆虫物种中进行测试，以评估这些设计和组件在不同昆虫中被认为是“标准化”的程度，或者可能需要物种特异性修改，如果是后者，则推导出指示如何做到这一点的一般规则。