OCULAR MOTOR DISORDERS

拟议研究的目标仍然是了解更多关于 损害视力的人类眼球运动障碍及其评价 治疗措施。研究策略是：(1)研究 自然行为，如联合眼头跟踪；(2)相关 眼球运动的可靠测量对视觉投诉的影响 患者；(3)解读正常眼和异常眼的控制 使用基于已知知识的数学模型的运动 生理特性。通过这种方式，我们计划应用新知识 病机对中医辨证论治的启示 眼球运动。 这项提案有五个目标，这些目标是从先前的工作中得出的。一是 评价肉毒杆菌毒素注射对部分患者的作用 眼外肌作为治疗视力受损和 获得性眼球震颤引起的视震荡。通过在以下位置选择患者 谁通过电子手段改善了视网膜图像的稳定性 愿景，应该有可能产生可观的，如果是暂时的， 症状改善。另外两个项目涉及对 扭曲的眼球运动，将它们与视觉需求联系起来， 他们提供服务。我们将关注正常的视觉-前庭互动， 并调查导致抑制的机制 受试者观看移动显示器时的前庭眼球运动 在滚转平面上用他们的头。我们还将学习扭转 垂直或水平运动障碍患者的眼球运动 凝视，以确定是否累及扭转系统。其目的是 第四个项目是比较眼球的动态特性 结合眼头的平滑追逐眼球运动 跟踪，后者是更自然的视觉跟踪方式 移动的物体。第五个项目的目标是确定如何 大脑皮质损害的分散、单侧损害合并 眼头跟踪，相比单纯的眼睛流畅追逐。 这些项目将提供(1)对一种新疗法的评估 获得性眼球震颤引起的视觉症状的方法；(2)新的 关于眼球扭转运动和缺陷的作用的信息 由疾病产生；(3)对如何自然、结合、 眼睛-头部跟踪可以清楚地看到移动的对象，以及如何 这种追踪会受到影响次级视觉的病变的影响 大脑皮层的区域。

The objective of the proposed research remains to learn more about human ocular motor disorders that impair vision, and to appraise therapeutic measures. The research strategy is to (1) study natural behaviors such as combined eye-head tracking; (2) relate reliable measurements of eye movements to visual complaints of patients; (3) interpret the control of normal and abnormal eye movements using mathematical models that are based on known physiologic properties. In this way we plan to apply new knowledge of pathogenesis to the diagnosis and treatment of disorders of ocular motility. This proposal has five aims that emerge from prior work. One is to evaluate the role of botulinum toxin injections into selected extraocular muscles as a treatment for impaired vision and oscillopsia due to acquired nystagmus. By selecting patients in whom stabilization of retinal images by electronic means improves vision, it should be possible to produce appreciable, if temporary, improvement of symptoms. Two further projects concern study of torsional eye movements, relating them to the visual demands that they serve. We will focus on normal visuo-vestibular interaction, and investigate the mechanisms that account for suppression of vestibular eye movements when subjects view a display that moves in the roll plane with their heads. We will also study torsional eye movements in patients with disorders of vertical or horizontal gaze, to identify the involvement of the torsional system. The aim of a fourth project is to compare dynamic properties of ocular smooth-pursuit eye movements with those of combined eye-head tracking, the latter being the more natural way to visually track a moving object. The aim of the fifth project is to determine how discrete, unilateral lesions of cerebral cortex impair combined eye-head tracking, compared with purely ocular smooth pursuit. These projects will provide (1) an evaluation of a new treatment method for visual symptoms due to acquired nystagmus; (2) new information on the role of torsional eye movements and the deficits produced by disease; (3) new insights into how natural, combined, eye-head tracking allows a clear view of a moving object, and how such tracking is affected by lesions affecting secondary visual areas in cerebral cortex.